Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Wenke, Jonas"'
Autor:
Georgia Lenihan‐Geels, Francisco Garcia Carrizo, Marina Leer, Sabrina Gohlke, Moritz Oster, Sophie Pöhle‐Kronawitter, Christiane Ott, Alexandra Chadt, Isabel N. Reinisch, Markus Galhuber, Chen Li, Wenke Jonas, Markus Jähnert, Susanne Klaus, Hadi Al‐Hasani, Tilman Grune, Annette Schürmann, Tobias Madl, Andreas Prokesch, Michael Schupp, Tim J. Schulz
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1772-1784 (2024)
Abstract Background The ability of skeletal muscle to respond adequately to changes in nutrient availability, known as metabolic flexibility, is essential for the maintenance of metabolic health and loss of flexibility contributes to the development
Externí odkaz:
https://doaj.org/article/6dc15b690f604a70b8d64e36ef498037
Autor:
Simran Chopra, Otsuware Linda-Josephine Kadiri, Jannis Ulke, Robert Hauffe, Wenke Jonas, Sahar Cheshmeh, Luisa Schmidt, Christopher A. Bishop, Selma Yagoub, Mareike Schell, Michaela Rath, Janine Krüger, Rachel N. Lippert, Marcus Krüger, Kai Kappert, André Kleinridders
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 114984- (2024)
Summary: A healthy metabolism relies on precise regulation of anabolic and catabolic pathways. While insulin deficiency impairs anabolism, insulin resistance in obesity causes metabolic dysfunction, especially via altered brain insulin receptor (IR)
Externí odkaz:
https://doaj.org/article/64bbfe6718224c24ba3e8e674c800a6a
Autor:
Jasmin Gaugel, Neele Haacke, Ratika Sehgal, Markus Jähnert, Wenke Jonas, Anne Hoffmann, Matthias Blüher, Adhideb Ghosh, Falko Noé, Christian Wolfrum, Joycelyn Tan, Annette Schürmann, Daniel J. Fazakerley, Heike Vogel
Publikováno v:
Molecular Metabolism, Vol 88, Iss , Pp 102014- (2024)
Objective: Picalm (phosphatidylinositol-binding clathrin assembly protein), a ubiquitously expressed clathrin-adapter protein, is a well-known susceptibility gene for Alzheimer's disease, but its role in white adipose tissue (WAT) function has not ye
Externí odkaz:
https://doaj.org/article/e91ee5beb1f043a1b62ff3f522be0fb8
Autor:
Robert Hauffe, Michaela Rath, Mareike Schell, Katrin Ritter, Kai Kappert, Stefanie Deubel, Christiane Ott, Markus Jähnert, Wenke Jonas, Annette Schürmann, André Kleinridders
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101276- (2021)
Objective: Insulin regulates mitochondrial function, thereby propagating an efficient metabolism. Conversely, diabetes and insulin resistance are linked to mitochondrial dysfunction with a decreased expression of the mitochondrial chaperone HSP60. Th
Externí odkaz:
https://doaj.org/article/8e70c968a1694ff39c2a66f6cc5ab0a2
Autor:
Wenke Jonas, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 50, Iss , Pp 101111- (2021)
Background: Hepatic steatosis is a common chronic liver disease that can progress into more severe stages of NAFLD or promote the development of life-threatening secondary diseases for some of those affected. These include the liver itself (nonalcoho
Externí odkaz:
https://doaj.org/article/082e0fa38aff4c7c97960d7849486fe0
Autor:
Anneke Gässler, Charline Quiclet, Oliver Kluth, Pascal Gottmann, Kristin Schwerbel, Anett Helms, Mandy Stadion, Ilka Wilhelmi, Wenke Jonas, Meriem Ouni, Frank Mayer, Joachim Spranger, Annette Schürmann, Heike Vogel
Publikováno v:
Molecular Metabolism, Vol 41, Iss , Pp 101042- (2020)
Objective: Altered gene expression contributes to the development of type 2 diabetes (T2D); thus, the analysis of differentially expressed genes between diabetes-susceptible and diabetes-resistant mouse models is an important tool for the determinati
Externí odkaz:
https://doaj.org/article/778cc7a0ad9d48c0a3bf529338b48bfb
Autor:
Richard Kehm, Markus Jähnert, Stefanie Deubel, Tanina Flore, Jeannette König, Tobias Jung, Mandy Stadion, Wenke Jonas, Annette Schürmann, Tilman Grune, Annika Höhn
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101748- (2020)
Overnutrition contributes to insulin resistance, obesity and metabolic stress, initiating a loss of functional beta-cells and diabetes development. Whether these damaging effects are amplified in advanced age is barely investigated. Therefore, New Ze
Externí odkaz:
https://doaj.org/article/138edc8bf6264d7b9a4ac437f70b3559
Autor:
Robert Hauffe, Michaela Rath, Wilson Agyapong, Wenke Jonas, Heike Vogel, Tim J. Schulz, Maria Schwarz, Anna P. Kipp, Matthias Blüher, André Kleinridders
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 862 (2022)
The intake of high-fat diets (HFDs) containing large amounts of saturated long-chain fatty acids leads to obesity, oxidative stress, inflammation, and insulin resistance. The trace element selenium, as a crucial part of antioxidative selenoproteins,
Externí odkaz:
https://doaj.org/article/f0df0dd7af6b4c95b7dab059e4dcf45b
Autor:
Pascal Gottmann, Meriem Ouni, Sophie Saussenthaler, Julian Roos, Laura Stirm, Markus Jähnert, Anne Kamitz, Nicole Hallahan, Wenke Jonas, Andreas Fritsche, Hans-Ulrich Häring, Harald Staiger, Matthias Blüher, Pamela Fischer-Posovszky, Heike Vogel, Annette Schürmann
Publikováno v:
Molecular Metabolism, Vol 11, Iss , Pp 145-159 (2018)
Objective: Obesity and type 2 diabetes (T2D) arise from the interplay between genetic, epigenetic, and environmental factors. The aim of this study was to combine bioinformatics and functional studies to identify miRNAs that contribute to obesity and
Externí odkaz:
https://doaj.org/article/b43f895593b3447b9e47be298c257584
Autor:
Christian Benedict, Heike Vogel, Wenke Jonas, Anni Woting, Michael Blaut, Annette Schürmann, Jonathan Cedernaes
Publikováno v:
Molecular Metabolism, Vol 5, Iss 12, Pp 1175-1186 (2016)
Objective: Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbio
Externí odkaz:
https://doaj.org/article/7c74819e181c421c9b5c45752da6f2ca