Zobrazeno 1 - 10
of 278
pro vyhledávání: '"Wenjun Guo"'
Autor:
Yanjiang Xing, Yangfeng Hou, Tianfei Fan, Ran Gao, Xiaohang Feng, Bolun Li, Junling Pang, Wenjun Guo, Ting Shu, Jinqiu Li, Jie Yang, Qilong Mao, Ya Luo, Xianmei Qi, Peiran Yang, Chaoyang Liang, Hongmei Zhao, Wenhui Chen, Jing Wang, Chen Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 4, Pp 1726-1741 (2024)
Pulmonary hypertension (PH) is a fatal disorder characterized by pulmonary vascular remodeling and obstruction. The phosphodiesterase 4 (PDE4) family hydrolyzes cyclic AMP (cAMP) and is comprised of four subtypes (PDE4A–D). Previous studies have sh
Externí odkaz:
https://doaj.org/article/82a1a91c028b46718e666010f9ed51d1
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Haloxylon ammodendron holds significance as an ecological plant, showcasing remarkable adaptability to desert conditions, halophytic environments, and sand fixation. With its potential for carbon sequestration, it emerges as a pro
Externí odkaz:
https://doaj.org/article/bf18d3673a2840b3993df3687c8626a2
Autor:
Cheng-Yao Chiang, Songqing Fan, Hongmei Zheng, Wenjun Guo, Zehan Zheng, Yihua Sun, Chuanqi Zhong, Juan Zeng, Shuaihu Li, Min Zhang, Tian Xiao, Duo Zheng
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113003- (2023)
Summary: Oncogenic KRAS mutations are a key driver for initiation and progression in non-small cell lung cancer (NSCLC). However, how post-translational modifications (PTMs) of KRAS, especially methylation, modify KRAS activity remain largely unclear
Externí odkaz:
https://doaj.org/article/59d0d81c26bc4304bd1ffb60ae523376
Autor:
Mingyao Wang, Zhe Zhang, Jiangfeng Liu, Meiyue Song, Tiantian Zhang, Yiling Chen, Huiyuan Hu, Peiran Yang, Bolun Li, Xiaomin Song, Junling Pang, Yanjiang Xing, Zhujie Cao, Wenjun Guo, Hao Yang, Jing Wang, Juntao Yang, Chen Wang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Silicosis is the most prevalent and fatal occupational disease with no effective therapeutics, and currently used drugs cannot reverse the disease progress. Worse still, there are still challenges to be addressed to fully decipher the intric
Externí odkaz:
https://doaj.org/article/9efc923f429f46c5aac80c35ecd10210
Autor:
Tianfei Fan, Yangfeng Hou, Weipeng Ge, Tianhui Fan, Xiaohang Feng, Wenjun Guo, Xiaomin Song, Ran Gao, Jing Wang
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Fan, Hou et al. investigate the role of phosphodiesterase (PDE) 4 and the PDE4-cAMP-PKA pathway on hypertension, reporting that PDE4D is upregulated in hypertension induced by angiotensin II. The authors also show that Pde4d knockout in mouse SMCs at
Externí odkaz:
https://doaj.org/article/346e4f8f43224ac09335e59b4665d6c8
Autor:
Ved P. Sharma, Binwu Tang, Yarong Wang, Camille L. Duran, George S. Karagiannis, Emily A. Xue, David Entenberg, Lucia Borriello, Anouchka Coste, Robert J. Eddy, Gina Kim, Xianjun Ye, Joan G. Jones, Eli Grunblatt, Nathan Agi, Sweta Roy, Gargi Bandyopadhyaya, Esther Adler, Chinmay R. Surve, Dominic Esposito, Sumanta Goswami, Jeffrey E. Segall, Wenjun Guo, John S. Condeelis, Lalage M. Wakefield, Maja H. Oktay
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Intravital imaging reveals macrophage-driven de novo induction of cancer stem cells in vivo, and their dramatic enrichment on dissemination through TMEM doorways. These findings provide a mechanism for the validated ability of TMEM doorway density to
Externí odkaz:
https://doaj.org/article/16874c70de9d4ce4951a776b446b784a
Autor:
Wei Wei, Shujing Yang, Fan Yang, Xinyu Hu, Yuan Wang, Wenjun Guo, Biyue Yang, Xiang Xiao, Lin Zhu
Publikováno v:
Foods, Vol 12, Iss 13, p 2550 (2023)
The hazard of nitrite caused by microorganisms is the main food safety problem in the pickle production. To seek a method to control the nitrite hazards of pickles by regulating microbial community without additional substances, we focused on cold pl
Externí odkaz:
https://doaj.org/article/261e2601a0fa490aa5743cc095e46803
Autor:
Dandan Xu, Yang Wang, Wenjun Guo, Xingxing Li, Yue Liu, Yuqing Han, Hongming Zhang, Qiyan Wei, Yongsheng Wang, Yajuan Xu
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 11, Pp 104297- (2022)
This study aimed to investigate the chemical composition of Tribulus terrestris L. fruit (TT) extract named TT15 and its protective effect against ischemic stroke (IS) as well as corresponding mechanisms. The chemical composition of TT15 was analyzed
Externí odkaz:
https://doaj.org/article/8dc6463141204a6bbffb0f0a2ff9b06c
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Background: Ephedrine increased blood pressure due to the contractile properties of resistance vessels. Excessive contraction of the uterine arteries might cause fetal distress. This study was to determine the diameter of the uterine artery of female
Externí odkaz:
https://doaj.org/article/400ce7c521564570a6bd3d3ee4d685c0
Publikováno v:
Frontiers in Environmental Science, Vol 10 (2022)
The Belt and Road Initiative (BRI) significantly contributes to the world economy. However, the central part of the Belt and Road (B&R) is located in fragile ecological zones that are arid, semi-arid, or sub-humid. Using the entropy method, the econo
Externí odkaz:
https://doaj.org/article/f470715b26b34cafb27e37e8dd43576f