Zobrazeno 1 - 10
of 173
pro vyhledávání: '"Wenjun, Ju"'
Autor:
Tao Hu, Quanquan Ji, Xinxin Ke, Hufeng Zhou, Senfeng Zhang, Shengsheng Ma, Chenlin Yu, Wenjun Ju, Meiling Lu, Yu Lin, Yangjing Ou, Yingsi Zhou, Yibei Xiao, Chunlong Xu, Chunyi Hu
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract R-loop-triggered collateral single-stranded DNA (ssDNA) nuclease activity within Class 1 Type I CRISPR-Cas systems holds immense potential for nucleic acid detection. However, the hyperactive ssDNase activity of Cas3 introduces unwanted nois
Externí odkaz:
https://doaj.org/article/814c81b3af0e478eb569a55abc863455
Autor:
Athena Y. Gong, Ying Jin Qiao, Mengxuan Chen, Zubia Alam, Deepak K. Malhotra, Lance Dworkin, Wenjun Ju, William T. Gunning
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Ethyl carbamate (EC) is a process contaminant found in fermented foods and alcoholic beverages. Metabolic conversion of ethyl carbamate generates vinyl carbamate (VC), a carcinogenic metabolite. EC, as a Group 2A probable human carcinogen, and the mo
Externí odkaz:
https://doaj.org/article/94398cde3f994f248dc86b431cc97144
Autor:
Meiling Lu, Chenlin Yu, Yuwen Zhang, Wenjun Ju, Zhi Ye, Chenyang Hua, Jinze Mao, Chunyi Hu, Zhenhuang Yang, Yibei Xiao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant RNA-guided adaptive immune systems in prokaryotes. Their ability to cause
Externí odkaz:
https://doaj.org/article/84267b5219e74719a48722c57feb41b4
Publikováno v:
International Journal of Coal Science & Technology, Vol 11, Iss 1, Pp 1-19 (2024)
Abstract The post-peak characteristics of coal serve as a direct reflection of its failure process and are essential parameters for evaluating brittleness and bursting liability. Understanding the significant factors that influence post-peak characte
Externí odkaz:
https://doaj.org/article/0188c66c28ad4506a4d90058cbfa0ce7
Autor:
Camille Cohen, Rana Mhaidly, Hugo Croizer, Yann Kieffer, Renaud Leclere, Anne Vincent-Salomon, Catherine Robley, Dany Anglicheau, Marion Rabant, Aurélie Sannier, Marc-Olivier Timsit, Sean Eddy, Matthias Kretzler, Wenjun Ju, Fatima Mechta-Grigoriou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Chronic kidney disease (CKD) is a public health problem driven by myofibroblast accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized characteristic in kidney fibroblasts in CKD, but the role of different pop
Externí odkaz:
https://doaj.org/article/de7db42b9af84103b6be59d88deaefde
Publikováno v:
Journal of Diabetes Investigation, Vol 14, Iss 10, Pp 1183-1186 (2023)
Abstract The relationship between urinary endothelial growth factor (uEGF) and cardiovascular autonomic neuropathy (CAN) in adults with type 1 diabetes was evaluated. uEGF levels at baseline and standardized CAN measures were collected at baseline an
Externí odkaz:
https://doaj.org/article/2a30adf80192496d8357f0c488a62531
Autor:
J. David Smeijer, Donald E. Kohan, Peter Rossing, Ricardo Correa-Rotter, Adrian Liew, Sydney C.W. Tang, Dick de Zeeuw, Ron T. Gansevoort, Wenjun Ju, Hiddo J. Lambers Heerspink
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-9 (2023)
Abstract Background Insulin resistance (IR) is a pathophysiologic hallmark of type 2 diabetes and associated with the presence of chronic kidney disease (CKD). Experimental studies suggest that endothelin-1 increases IR. We assessed the association b
Externí odkaz:
https://doaj.org/article/5a8a0515db9b45b0b507829cb5bcedce
Autor:
Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlüter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over cultu
Externí odkaz:
https://doaj.org/article/39ed8a12de7946c9bcf28c0777cf6607
Autor:
Gong, Athena Y., Ying Jin Qiao, Mengxuan Chen, Alam, Zubia, Malhotra, Deepak K., Dworkin, Lance, Wenjun Ju, Gunning, William T.
Publikováno v:
Frontiers in Pharmacology; 2024, p1-13, 13p
Autor:
Debbie S. Gipson, Howard Trachtman, Anne Waldo, Keisha L. Gibson, Sean Eddy, Katherine M. Dell, Tarak Srivastava, Kevin V. Lemley, Larry A. Greenbaum, Sangeeta Hingorani, Kevin E. Meyers, Frederick J. Kaskel, Kimberly J. Reidy, Christine B. Sethna, Cheryl L. Tran, Chia-shi Wang, Katherine R. Tuttle, Gia Oh, Alicia M. Neu, Elizabeth Brown, Jen-Jar Lin, Jennifer Lai Yee, Therese M. Roth, Jonathan P. Troost, Brenda W. Gillespie, Matthew G. Sampson, Matthias Kretzler, Wenjun Ju
Publikováno v:
Kidney International Reports, Vol 5, Iss 4, Pp 414-425 (2020)
Introduction: Childhood-onset nephrotic syndrome has a variable clinical course. Improved predictive markers of long-term outcomes in children with nephrotic syndrome are needed. This study tests the association between baseline urinary epidermal gro
Externí odkaz:
https://doaj.org/article/0ec9bfee819e47e6a0c27426843af311