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Akademický článek

Forsythiaside B ameliorates coagulopathies in a rat model of sepsis through inhibition of the formation of PAD4-dependent neutrophil extracellular traps

Autor: Wenju He, Qiang Xi, Huantian Cui, Pingping Zhang, Rui Huang, Taihuan Wang, Dongqiang Wang

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Forsythiaside B (FTB) is one of the main components of Forsythia suspensa (Thunb.) Vahl and exerts anti-inflammatory and anti-oxidative effects. However, its mechanism of action as a treatment for sepsis remains unclear. In this study, we developed a

Externí odkaz: https://doaj.org/article/e3ad9924f34d449cbac45bf2393e16d2

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Akademický článek

Liang-Ge decoction ameliorates acute lung injury in septic model rats through reducing inflammatory response, oxidative stress, apoptosis, and modulating host metabolism

Autor: Wenju He, Qiang Xi, Huantian Cui, Pingping Zhang, Rui Huang, Taihuan Wang, Dongqiang Wang

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Liang-Ge decoction (LG) has been used in the treatment of early stage of spesis and can ameliorate sepsis-associated lung injury. However, the mechanism of LG on sepsis-associated lung injury remains unknown. In this study, we established a rat model

Externí odkaz: https://doaj.org/article/60cce53302fe4cbca99e68045015334f

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Akademický článek

Jian-Ti-Kang-Yi decoction alleviates poly(I:C)-induced pneumonia by inhibiting inflammatory response, reducing oxidative stress, and modulating host metabolism

Autor: Huantian Cui, Yuming Wang, Bolun Yu, Yulin Wu, Gaijun Zhang, Junli Guo, Junyu Luo, Qin Li, Xiaojuan Li, Wenju He, Weibo Wen, Jiabao Liao, Dongqiang Wang

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Jian-Ti-Kang-Yi decoction (JTKY) is widely used in the treatment of COVID-19. However, the protective mechanisms of JTKY against pneumonia remain unknown. In this study, polyinosinic-polycytidylic acid (poly(I:C)), a mimic of viral dsRNA, was used to

Externí odkaz: https://doaj.org/article/e38c4391f4d64211bf398b8bf27989ce

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Akademický článek

Geniposide Ameliorates Liver Fibrosis Through Reducing Oxidative Stress and Inflammatory Respose, Inhibiting Apoptosis and Modulating Overall Metabolism

Autor: Lu Yang, Liping Bi, Lulu Jin, Yuming Wang, Yuting Li, Zixuan Li, Wenju He, Huantian Cui, Jing Miao, Li Wang

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Liver fibrosis is a progressive liver damage condition caused by various factors and may progress toward liver cirrhosis, and even hepatocellular carcinoma. Many studies have found that the disfunction in metabolism could contribute to the developmen

Externí odkaz: https://doaj.org/article/007b33173beb4bc6bfeeebb8fa255313

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