Deciphering the complex relationship between type 2 diabetes and fracture risk with both genetic and observational evidence

Autor: Pianpian Zhao, Zhifeng Sheng, Lin Xu, Peng Li, Wenjin Xiao, Chengda Yuan, Zhanwei Xu, Mengyuan Yang, Yu Qian, Jiadong Zhong, Jiaxuan Gu, David Karasik, Hou-Feng Zheng

Publikováno v: eLife, Vol 12 (2024)

The ‘diabetic bone paradox’ suggested that type 2 diabetes (T2D) patients would have higher areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In this study, we found that the genetically predicted T2D was ass

Externí odkaz: https://doaj.org/article/e05426f7f8f84f158e7c15a544372d27

Intratumor heterogeneity and cell secretome promote chemotherapy resistance and progression of colorectal cancer

Autor: Julia Källberg, Alexandra Harrison, Valerie March, Santa Bērziņa, Ivan Nemazanyy, Oliver Kepp, Guido Kroemer, Sophie Mouillet-Richard, Pierre Laurent-Puig, Valérie Taly, Wenjin Xiao

Publikováno v: Cell Death and Disease, Vol 14, Iss 5, Pp 1-12 (2023)

Abstract The major underlying cause for the high mortality rate in colorectal cancer (CRC) relies on its drug resistance, to which intratumor heterogeneity (ITH) contributes substantially. CRC tumors have been reported to comprise heterogeneous popul

Externí odkaz: https://doaj.org/article/f3c2f693a1da46e99b45f5f98c739dd7

Deciphering Protein O-GalNAcylation: Method Development and Disease Implication

Autor: Shuang Yue, Xiaotong Wang, Wei Ge, Jiajia Li, Chuanlai Yang, Zeyang Zhou, Peng Zhang, Xiaodong Yang, Wenjin Xiao, Shuang Yang

Publikováno v: ACS Omega.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bb52dd355513767a37fde20e890684a
https://doi.org/10.1021/acsomega.3c01653

A Rationally Designed Supercharged Protein-Enzyme Chimera Self-Assembles In Situ to Yield Bifunctional Composite Textiles

Autor: Graham J. Day, William H. Zhang, Ben M. Carter, Wenjin Xiao, Mark R. Sambrook, Adam W. Perriman

Publikováno v: Day, G J, Zhang, W H, Carter, B, Xiao, W, Sambrook, M R & Perriman, A W 2021, ' A Rationally Designed Supercharged Protein-Enzyme Chimera Self-Assembles In Situ to Yield Bifunctional Composite Textiles. ', ACS Applied Materials and Interfaces, vol. 13, no. 50, pp. 60433−60445 . https://doi.org/10.1021/acsami.1c18857

Catalytically active materials for the enhancement of personalized protective equipment (PPE) could be advantageous to help alleviate threats posed by neurotoxic organophosphorus compounds (OPs). Accordingly, a chimeric protein comprised of a superch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51350255a508b46d20f2d05f9285510f
https://doi.org/10.1021/acsami.1c18857

Circadian Rhythm and Circulating Cell-Free DNA Release on Healthy Subjects

Autor: Geoffroy Poulet, Jean-Sébastien Hulot, Anne Blanchard, Damien Bergerot, Wenjin Xiao, Frederic Ginot, Audrey Boutonnet-Rodat, Guillaume Beinse, Vanna Geromel, Laurence Pellegrina, Michel Azizi, Pierre Laurent-Puig, Leonor Benhaim, Valerie Taly

Background In the last decade, clinical studies have investigated the clinical relevance of circulating cell-free-DNA (ccfDNA) as a diagnostic and prognosis tool in various diseases including cancers. However, limited knowledge on ccfDNA biology rest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b71c11571d282591e59dbf73c9e42fa
https://doi.org/10.21203/rs.3.rs-1270021/v1