Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Wenji, Yin"'
Autor:
Zecong Ye, Yueping Peng, Wenchao Liu, Wenji Yin, Hexiang Hao, Baixuan Han, Yanfei Zhu, Dong Xiao
Publikováno v:
Drones, Vol 8, Iss 4, p 144 (2024)
With the continuous advancement of drone technology, drones are demonstrating a trend toward autonomy and clustering. The detection of airborne objects from the perspective of drones is critical for addressing threats posed by aerial targets and ensu
Externí odkaz:
https://doaj.org/article/65513204041f408c8641da13ccdc450a
Publikováno v:
Applied Sciences, Vol 13, Iss 21, p 11651 (2023)
Vehicle re-identification research under surveillance cameras has yielded impressive results. However, the challenge of unmanned aerial vehicle (UAV)-based vehicle re-identification (ReID) presents a high degree of flexibility, mainly due to complica
Externí odkaz:
https://doaj.org/article/554dbe6b4f554eeea1727265e0d189b5
Autor:
Xinchun Tong, Yue Feng, Lauren P. Shearman, William K. Hagmann, Koppara Samuel, Jing Chen Xiao, Shrenik K. Shah, Hongbo Qi, Junying Wang, Sanjeev Kumar, Kimberly Rosko, Tung M. Fong, Wenji Yin, Ping Liu, D. Sloan Stribling, Linus S. Lin, Alison M. Strack, Chun-Pyn Shen, Julie Lao, Donald J. Marsh, James P. Jewell, Lex H.T. Van der Ploeg, Thomas J. Lanza, Mark T. Goulet, Suoyu S. Xu
Publikováno v:
Journal of Medicinal Chemistry. 49:7584-7587
The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in rodent models of food intake and body weight reduction. A major focus of the optimization proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703cbf2be468c2f985946aa5e12958db
https://doi.org/10.1021/jm060996+
https://doi.org/10.1021/jm060996+
Publikováno v:
Drug Metabolism and Disposition. 32:43-48
We report herein the identification of a novel metabolic pathway that involves acetylation of the amino group of the glutamic acid residue of intact glutathione (GSH) conjugates of a series of compounds in rat hepatocytes and in rats in vivo. The "no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960dd409cbf4b85e478936b8a8c40697
https://doi.org/10.1124/dmd.32.1.43
https://doi.org/10.1124/dmd.32.1.43
Autor:
Wenji Yin, Ashok Chaudhary, Cornelis E. C. A. Hop, Sanjeev Kumar, Ralph A. Stearns, Ronald B. Franklin, George A. Doss
Publikováno v:
Drug Metabolism and Disposition. 31:215-223
We describe herein a novel metabolic fate of the 2,2,6,6-tetramethyl-piperidine (2,2,6,6-TMPi) moiety to a ring-contracted 2,2-dimethyl pyrrolidine (2,2-DMPy) in human liver microsomal incubations. The existence of this pathway was demonstrated for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ff4df0932c812a034fb24eeb25f693
https://doi.org/10.1124/dmd.31.2.215
https://doi.org/10.1124/dmd.31.2.215
Autor:
James P. Jewell, Joseph F. Payack, Stephen Krause, Wenji Yin, Shawn A. Springfield, Thomas J. Lanza, Terence G. Hamill, Mark T. Goulet, Richard Hargreaves, Chun-Pyn Shen, Julie Lao, Ping Liu, Xinchun Tong, Linus S. Lin, Dorothy A. Levorse, Christine Ryan, Wai-Si Eng, Junying Wang, Tung M. Fong, Karen Owens, William K. Hagmann, Sandra Sanabria, Raymond E. Gibson, Sanjeev Kumar, H. Donald Burns
Publikováno v:
Journal of medicinal chemistry. 50(15)
The discovery of a structurally distinct cannabinoid-1 receptor (CB1R) positron emission tomography tracer is described. Starting from an acyclic amide CB1R inverse agonist (1) as the lead compound, an efficient route to introduce 18F to the molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0056c83d9237bd8f561748263d074ff
https://pubmed.ncbi.nlm.nih.gov/17608398
https://pubmed.ncbi.nlm.nih.gov/17608398
Autor:
Linus S, Lin, Thomas J, Lanza, James P, Jewell, Ping, Liu, Shrenik K, Shah, Hongbo, Qi, Xinchun, Tong, Junying, Wang, Suoyu S, Xu, Tung M, Fong, Chun-Pyn, Shen, Julie, Lao, Jing Chen, Xiao, Lauren P, Shearman, D Sloan, Stribling, Kimberly, Rosko, Alison, Strack, Donald J, Marsh, Yue, Feng, Sanjeev, Kumar, Koppara, Samuel, Wenji, Yin, Lex H T, Van der Ploeg, Mark T, Goulet, William K, Hagmann
Publikováno v:
Journal of medicinal chemistry. 49(26)
The discovery of novel acyclic amide cannabinoid-1 receptor inverse agonists is described. They are potent, selective, orally bioavailable, and active in rodent models of food intake and body weight reduction. A major focus of the optimization proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23acaa1470f2a563abfd6b678dbb85a6
https://pubmed.ncbi.nlm.nih.gov/17181138
https://pubmed.ncbi.nlm.nih.gov/17181138
Publikováno v:
Biochemistry. 43(18)
Earlier we described a novel cytochrome P450 (CYP) catalyzed metabolism of the 2,2,6,6-tetramethylpiperidine (2,2,6,6-TMPi) moiety in human liver microsomes to a ring-contracted 2,2-dimethylpyrrolidine (2,2-DMPy) [Yin, W., et al. (2003) Drug Metab. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f51d10b8a12739c5cd0487e82fba31
https://pubmed.ncbi.nlm.nih.gov/15122911
https://pubmed.ncbi.nlm.nih.gov/15122911
Autor:
William K. Hagmann, Wenji Yin, Linus S. Lin, Ashok Chaudhary, Thomas J. Lanza, Yui S. Tang, Ralph A. Stearns, Koppara Samuel, David C. Evans, Sanjeev Kumar, James P. Jewell
Publikováno v:
Journal of mass spectrometry : JMS. 38(2)
Metabolic activation of drug candidates to electrophilic reactive metabolites that can covalently modify cellular macromolecules may result in acute and/or idiosyncratic immune system-mediated toxicities in humans. This presents a significant potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83540efb60a0e9cf6329f837bab0b08a
https://pubmed.ncbi.nlm.nih.gov/12577288
https://pubmed.ncbi.nlm.nih.gov/12577288
Autor:
Ping Liu, Linus S. Lin, Terence G. Hamill, James P. Jewell, Thomas J. Lanza Jr, Raymond E. Gibson, Stephen M. Krause, Christine Ryan, Waisi Eng, Sandra Sanabria, Xinchun Tong, Junying Wang, Dorothy A. Levorse, Karen A. Owens, Tung M. Fong, Chun-Pyn Shen, Julie Lao, Sanjeev Kumar, Wenji Yin, Joseph F. Payack
Publikováno v:
Journal of Medicinal Chemistry; Jul2007, Vol. 50 Issue 15, p3427-3430, 4p