Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Wenhe Zhong"'
Autor:
Wenhe Zhong, Liang Cui, Boon Chong Goh, Qixu Cai, Peiying Ho, Yok Hian Chionh, Meng Yuan, Abbas El Sahili, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw, Julien Lescar, Peter C. Dedon
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Pyruvate kinase (PYK) controls glycolytic flux. Here, the authors combine biochemical, structural and computational modelling studies to characterize the allosteric mechanisms regulating Mycobacterium tuberculosis PYK activity and show that AMP and g
Externí odkaz:
https://doaj.org/article/1ccbb8a01a5d4d8c9f866502136c19e3
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 8803-8819 (2014)
A series of N-mustards, which was conjugated to mono- or bis-naphthalimides with a flexible amine link, were synthesized and evaluated for cytotoxicity against five cancer cell lines (HCT-116, PC-3, U87 MG, Hep G2 and SK-OV-3). Several compounds disp
Externí odkaz:
https://doaj.org/article/d91d8b6749b948a4a6f8f9269652e665
Autor:
Hugh P. Morgan, Wenhe Zhong, Iain W. McNae, Paul A. M. Michels, Linda A. Fothergill-Gilmore, Malcolm D. Walkinshaw
Publikováno v:
Royal Society Open Science, Vol 1, Iss 1 (2014)
The transition between the inactive T-state (apoenzyme) and active R-state (effector bound enzyme) of Trypanosoma cruzi pyruvate kinase (PYK) is accompanied by a symmetrical 8° rigid body rocking motion of the A- and C-domain cores in each of the fo
Externí odkaz:
https://doaj.org/article/b7411e07cd9e47569f4972c21c4a6542
Autor:
Jiawei Zhou, Leixiang Gu, Zhenghua Zhu, Dongsheng Liu, Wenhe Zhong, Xueying Li, Lizhuang Chen, Xiaofang Cheng, Yuanyuan Dan
Publikováno v:
International Journal of Hydrogen Energy. 47:11962-11974
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3116f92199302c65a495e20323c483d
https://doi.org/10.1016/j.ijhydene.2022.01.155
https://doi.org/10.1016/j.ijhydene.2022.01.155
Autor:
Weilong Shi, Longwen Cao, Yuxing Shi, Wenhe Zhong, Zhouze Chen, Yidan Wei, Feng Guo, Lizhuang Chen, Xin Du
Publikováno v:
Journal of Molecular Structure. 1280:135076
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dcf0cb73dd795a3cac6d5b3f3df980d
https://doi.org/10.1016/j.molstruc.2023.135076
https://doi.org/10.1016/j.molstruc.2023.135076
Autor:
Kehe Chen, Zhenxiang Chen, Mei Ou, Junping Wang, Xiao Huang, Yingying Wu, Wenhe Zhong, Jiao Yang, Jinging Huang, Min Huang, Deng Pan
Publikováno v:
Clinics, Volume: 77, Article number: 100070, Published: 10 OCT 2022
Background: Relapse and metastasis of patients with Colorectal Cancer (CRC) is the major obstacle to the long-term life of patients. Its mechanisms remain defined. Methods: A total of 48 CRC patients were enrolled and 68 samples were obtained from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0bc04143c8287adabe65b775ce257d
https://pubmed.ncbi.nlm.nih.gov/36087570
https://pubmed.ncbi.nlm.nih.gov/36087570
Autor:
Chuanfei, Jin, Chao, Yi, Wenhe, Zhong, Yaping, Xue, Kangzhi, Chen, Kang, Deng, Zusheng, Wang, Tao, Wang
Publikováno v:
European journal of medicinal chemistry. 225
Migraine is a common neurovascular disease which has been classified as the sixth most disabling disorder. Current migraine therapy was triptans, however, riptans can cause contraction of blood vessels. Therefore, novel drugs without cardiovascular e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1ed0db655e945c6b90fca8e032cc1ad4
https://pubmed.ncbi.nlm.nih.gov/34419891
https://pubmed.ncbi.nlm.nih.gov/34419891
Autor:
Kuohan Li, Malcolm D. Walkinshaw, Abbas El Sahili, Paul A.M. Michels, Yok Hian Chionh, Julien Lescar, Yuguang Mu, Wenhe Zhong, Jingjing Guo, Qixu Cai, Meng Yuan, Linda A. Fothergill-Gilmore, Liang Cui, Peter C. Dedon
Publikováno v:
Josephina Lee
Zhong, W, Guo, J, Cui, L, Chionh, Y H, Li, K, El Sahili, A, Cai, Q, Yuan, M, Michels, P A M, Fothergill-Gilmore, L A, Walkinshaw, M D, Mu, Y, Lescar, J & Dedon, P C 2019, ' Pyruvate Kinase regulates the Pentose-Phosphate pathway in Response to Hypoxia in Mycobacterium tuberculosis ', Journal of Molecular Biology, vol. 431, no. 19, pp. 3690-3705 . https://doi.org/10.1016/j.jmb.2019.07.033
Zhong, W, Guo, J, Cui, L, Chionh, Y H, Li, K, El Sahili, A, Cai, Q, Yuan, M, Michels, P A M, Fothergill-Gilmore, L A, Walkinshaw, M D, Mu, Y, Lescar, J & Dedon, P C 2019, ' Pyruvate Kinase regulates the Pentose-Phosphate pathway in Response to Hypoxia in Mycobacterium tuberculosis ', Journal of Molecular Biology, vol. 431, no. 19, pp. 3690-3705 . https://doi.org/10.1016/j.jmb.2019.07.033
In response to the stress of infection, Mycobacterium tuberculosis (Mtb) reprograms its metabolism to accommodate nutrient and energetic demands in a changing environment. Pyruvate kinase (PYK) is an essential glycolytic enzyme in the phosphoenolpyru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8765160b5a98fd818d08169877ecc1
https://doi.org/10.1016/j.jmb.2019.07.033
https://doi.org/10.1016/j.jmb.2019.07.033
Autor:
Kalyan Kumar Pasunooti, Pooja Gopal, Shanmugavel Gnanakalai, Nelson B. Olivier, Siau Hoi Lim, Julien Lescar, Seetharamsing Balamkundu, Vinod Gadi, Wenhe Zhong, Peter C. Dedon, Chuan-Fa Liu, Yok Hian Chionh, Ed T. Buurman, Thomas Dick, Megan E. McBee, Qianhui Nah, Yee Hwa Wong
Publikováno v:
Journal of Medicinal Chemistry. 62:7788-7805
Among the >120 modified ribonucleosides in the prokaryotic epitranscriptome, many tRNA modifications are critical to bacterial survival, which makes their synthetic enzymes ideal targets for antibiotic development. Here we performed a structure-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::550e33b18ac78640a1f11420a6243e12
https://doi.org/10.1021/acs.jmedchem.9b00582
https://doi.org/10.1021/acs.jmedchem.9b00582
Autor:
Somchart Maenpuen, Narumon Thongdee, Erin G. Prestwich, Skorn Mongkolsuk, Wenhe Zhong, Abbas El Sahili, Sopapan Atichartpongkul, Yok Hian Chionh, Megan E. McBee, Julien Lescar, Chong Wai Liew, Juthamas Jaroensuk, Pimchai Chaiyen, Yee Hwa Wong, Peter C. Dedon, Michael S. DeMott, Mayuree Fuangthong, Qianhui Nah
Publikováno v:
RNA. 25:1481-1496
The tRNA (m1G37) methyltransferase TrmD catalyzes m1G formation at position 37 in many tRNA isoacceptors and is essential in most bacteria, which positions it as a target for antibiotic development. In spite of its crucial role, little is known about
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10d0f9510160f0ccf682b4a455242e3b
https://doi.org/10.1261/rna.066746.118
https://doi.org/10.1261/rna.066746.118