Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Wenhao O. Ouyang"'
Autor:
Ruipeng Lei, Weiwen Liang, Wenhao O. Ouyang, Andrea Hernandez Garcia, Chika Kikuchi, Shengyang Wang, Ryan McBride, Timothy J. C. Tan, Yuanxin Sun, Chunke Chen, Claire S. Graham, Lucia A. Rodriguez, Ivana R. Shen, Danbi Choi, Roberto Bruzzone, James C. Paulson, Satish K. Nair, Chris K. P. Mok, Nicholas C. Wu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The receptor-binding site of influenza A virus hemagglutinin partially overlaps with major antigenic sites and constantly evolves. In this study, we observe that mutations G186D and D190N in the hemagglutinin receptor-binding site have coevo
Externí odkaz:
https://doaj.org/article/c60b17324d1f49b88d25cffb3c14c7d7
Autor:
Ruipeng Lei, Enya Qing, Abby Odle, Meng Yuan, Chaminda D. Gunawardene, Timothy J. C. Tan, Natalie So, Wenhao O. Ouyang, Ian A. Wilson, Tom Gallagher, Stanley Perlman, Nicholas C. Wu, Lok-Yin Roy Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The fusion peptide of SARS-CoV-2 spike protein is functionally important for membrane fusion during virus entry and is part of a broadly neutralizing epitope. However, sequence determinants at the fusion peptide and its adjacent regions for
Externí odkaz:
https://doaj.org/article/be4e9943c217458b99039b79fd1789b0
Autor:
Timothy J. C. Tan, Zongjun Mou, Ruipeng Lei, Wenhao O. Ouyang, Meng Yuan, Ge Song, Raiees Andrabi, Ian A. Wilson, Collin Kieffer, Xinghong Dai, Kenneth A. Matreyek, Nicholas C. Wu
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to stabilize its prefusion conformation. However, contemporary me
Externí odkaz:
https://doaj.org/article/edd8cd5ae497476d8f8b6a6d91cc4a43
Autor:
Meng Yuan, Ziqi Feng, Huibin Lv, Natalie So, Ivana R. Shen, Timothy J.C. Tan, Qi Wen Teo, Wenhao O. Ouyang, Logan Talmage, Ian A. Wilson, Nicholas C. Wu
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113194- (2023)
Summary: The ability of the human immune system to generate antibodies to any given antigen can be strongly influenced by immunoglobulin V-gene allelic polymorphisms. However, previous studies have provided only limited examples. Therefore, the preva
Externí odkaz:
https://doaj.org/article/d1d4dec35ad34509ab52271c250886a8
Autor:
Yunling Deng, Sudharsan Dwaraknath, Wenhao O. Ouyang, Cory J. Matsumoto, Stephanie Ouchida, Yi Lu
Publikováno v:
Angewandte Chemie International Edition. 62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d5d6c25df7cbf2aec2841556876443c
https://doi.org/10.1002/anie.202215719
https://doi.org/10.1002/anie.202215719
Autor:
Wenhao O. Ouyang, Timothy J.C. Tan, Ruipeng Lei, Ge Song, Collin Kieffer, Raiees Andrabi, Kenneth A. Matreyek, Nicholas C. Wu
Publikováno v:
Science advances. 8(47)
Increasing the expression level of the SARS-CoV-2 spike (S) protein has been critical for COVID-19 vaccine development. While previous efforts largely focused on engineering the receptor-binding domain (RBD) and the S2 subunit, the N-terminal domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40baa228f5caf6925be08c38228a0cc5
https://pubmed.ncbi.nlm.nih.gov/36417523
https://pubmed.ncbi.nlm.nih.gov/36417523