Cardiac performance is limited by oxygen delivery to the mitochondria in the crystalloid-perfused working heart.

Autor: Kuzmiak-Glancy S; Department of Biomedical Engineering, The George Washington University , Washington, District of Columbia.; Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland., Covian R; Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland., Femnou AN; Department of Biomedical Engineering, The George Washington University , Washington, District of Columbia.; Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland., Glancy B; Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland., Jaimes R 3rd; Department of Biomedical Engineering, The George Washington University , Washington, District of Columbia., Wengrowski AM; Department of Biomedical Engineering, The George Washington University , Washington, District of Columbia., Garrott K; Department of Biomedical Engineering, The George Washington University , Washington, District of Columbia., French SA; Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland., Balaban RS; Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health , Bethesda, Maryland., Kay MW; Department of Biomedical Engineering, The George Washington University , Washington, District of Columbia.

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2018 Apr 01; Vol. 314 (4), pp. H704-H715. Date of Electronic Publication: 2017 Nov 10.

Optogenetic release of norepinephrine from cardiac sympathetic neurons alters mechanical and electrical function.

Autor: Wengrowski AM; Department of Biomedical Engineering, The George Washington University, Phillips Hall, Room 607, 801 22nd Street NW, Washington, DC 20052, USA., Wang X; Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA., Tapa S; Department of Biomedical Engineering, The George Washington University, Phillips Hall, Room 607, 801 22nd Street NW, Washington, DC 20052, USA., Posnack NG; Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA., Mendelowitz D; Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA., Kay MW; Department of Biomedical Engineering, The George Washington University, Phillips Hall, Room 607, 801 22nd Street NW, Washington, DC 20052, USA Department of Pharmacology and Physiology, The George Washington University, Washington, DC, USA kaymwk@gmail.com.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2015 Feb 01; Vol. 105 (2), pp. 143-50. Date of Electronic Publication: 2014 Dec 16.

NADH changes during hypoxia, ischemia, and increased work differ between isolated heart preparations.

Autor: Wengrowski AM; Department of Electrical and Computer Engineering, The George Washington University, Washington, District of Columbia; and., Kuzmiak-Glancy S, Jaimes R 3rd, Kay MW

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2014 Feb 15; Vol. 306 (4), pp. H529-37. Date of Electronic Publication: 2013 Dec 13.