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Part 1, Glyoxal-guanine DNA adducts, derivatization, structure, stability and new detection methodology ; Part 2, Nitrosation studies of oxazolines and imidazolines and the synthesis of N-cyclopropyl aromatic amines

Autor: Cui, Wenge, Cui, Wenge

Publikováno v: free to MU campus, to others for purchase.

Thesis (Ph. D.)--University of Missouri-Columbia, 2000.
Typescript. Vita. Includes bibliographical references. Also available on the Internet.

Externí odkaz: http://wwwlib.umi.com/cr/mo/fullcit?p9998477

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Enantioselective synthesis of BMS-911278: a triple reuptake inhibitor

Autor: Dawn Sun, Kristen N. Ryan, Daniel Smith, Subramaniam Krishnananthan, Min Hu, Dauh-Rurng Wu, Wenge Cui, Paul C. Lobben, Arvind Mathur, Shuang Liu, Jennifer Naginskaya, Richard E. Olson, Peng Li, Jianqing Li, Alicia Ng

Publikováno v: Tetrahedron: Asymmetry. 28:196-202

BMS-911278 was identified as a potent triple reuptake inhibitor potentially useful for the treatment of depression. The original racemic synthesis suffered from tedious and low recovery resolution and HPLC separation, as well as low-yielding hazardou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cd99d111ddccc082e4c2c89c67ec4c3f
https://doi.org/10.1016/j.tetasy.2016.12.003

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Enabling Synthesis of Triple Reuptake Inhibitor (+)-BMS-820836, a Potential Therapeutic Agent for the Treatment of Depression

Autor: Yuh-Lin Yang, Min Hu, Shuang Liu, Brandon Miles, Bingidimi I. Mobele, Wenge Cui, Richard E. Olson, Rulin Zhao, Kassoum Nacro, Matthew Isherwood, Bei Wang, Paul C. Lobben, Rasidul Amin, Bang-Chi Chen

Publikováno v: Organic Process Research & Development. 20:44-50

Herein, we describe the enabling synthesis of (+)-BMS-820836, a 4,7-disubstituted tetrahydroisoquinoline which was developed as a treatment for a range of neurological diseases, including depression and neurophatic pain. In order to advance the drug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f8aad4c7ab58a16fd03472a1a59ee37
https://doi.org/10.1021/acs.oprd.5b00261

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The synthesis of N -arylcyclopropylamines via palladium-catalyzed C–N bond formation

Autor: Wenge Cui, Richard N. Loeppky

Publikováno v: Tetrahedron. 57:2953-2956

A variety of N-arylcyclopropylamines has been prepared in one step, by the Pd2(dba)3/BINAP/NaOtBu-catalyzed amination of an aryl bromide with cyclopropylamine. Compounds bearing the N-aryl substitutent (phenyl, 4-methylphenyl, 2-methoxyphenyl, 3-meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::963f7bbbd30a97641217531047c82b04
https://doi.org/10.1016/s0040-4020(01)00118-1

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The nitrosation of imidazolines and oxazolines

Autor: Wenge Cui, Richard N. Loeppky

Publikováno v: Tetrahedron Letters. 39:1845-1848

Nitrosation ( HOAc NaNO 2 ) of 1-methyl-2-phenyl-2-imidazoline 8 results in cleavage of only the CN single bond and production of N-(2-methylnitrosaminoethyl)-N-nitrosobenzamide 10. In contrast, 2-phenyl-2-oxazoline 9 nitrosates very rapidly to gi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a398c970b4259e49d4bb8f5efcb117ad
https://doi.org/10.1016/s0040-4039(98)00128-2

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