Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Weng Ieong Tou"'
Autor:
Hou Hon Cheong, Fong I Sio, Chi Chung Chan, Seong In Neng, Ip Pio Sam, Teng Cheang, Weng Ieong Tou, Hong San Lei, Tan Fong Cheong, Edmundo Patricio Lopes Lao, Tak Hong Cheong, Cheong U Kuok, Iek Long Lo
Publikováno v:
Health Science Reports, Vol 6, Iss 7, Pp n/a-n/a (2023)
Abstract Background and Aims The evolving mutants of SARS‐CoV‐2 have made the COVID‐19 pandemic sustained for over 3 years. In 2022, BA.4 and BA.5 were the Omicron variants dominating the spread globally. Although COVID‐19 was no longer a Pub
Externí odkaz:
https://doaj.org/article/937bbedd4a7f49aeb8d9396ac8f0bf2d
Autor:
Weng Ieong Tou, Calvin Yu-Chian Chen
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33728 (2012)
Src kinase is an attractive target for drug development based on its established relationship with cancer and possible link to hypertension. The suitability of traditional Chinese medicine (TCM) compounds as potential drug ligands for further biologi
Externí odkaz:
https://doaj.org/article/305ef604f5eb4941904b87e9f3a66545
Publikováno v:
Current topics in medicinal chemistry. 20(15)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae3e3f06b692a5c3f1d1ea3b26a8b2e
https://pubmed.ncbi.nlm.nih.gov/32427084
https://pubmed.ncbi.nlm.nih.gov/32427084
Autor:
Jian-hua Ran, Weng-Ieong Tou, Tianluo Lei, Hong Zhou, Calvin Yu-Chian Chen, Min Li, Baoxue Yang
Publikováno v:
Acta Pharmacologica Sinica. 37:973-983
Urea transporters (UT) are a family of transmembrane proteins that specifically transport urea. UT inhibitors exert diuretic activity without affecting electrolyte balance. The purpose of this study was to discover novel UT inhibitors and determine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7881ff6ed5a69fe0d6fc041762c7ae00
https://doi.org/10.1038/aps.2016.4
https://doi.org/10.1038/aps.2016.4
Autor:
Calvin Yu-Chian Chen, Weng Ieong Tou
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 30:299-317
This study utilizes the comprehensive traditional Chinese medicine database TCM Database@Taiwan ( http://tcm.cmu.edu.tw/ ) in conjunction with structure-based and ligand-based drug design to identify multi-function Src inhibitors. The three potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27eef1477e3241a0544a64f7e2b922f
https://doi.org/10.1080/07391102.2012.680030
https://doi.org/10.1080/07391102.2012.680030
Publikováno v:
Journal of molecular modeling. 22(1)
Point mutations H274Y and N294S can lead to resistance of influenza virus strains to some drug molecules. Recently, a large number of experiments has focused on the many frameworks and catalytic residues thought to prevent the efficacy of anti-flu dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdcdae7e4457591437a6420e523eaa38
https://pubmed.ncbi.nlm.nih.gov/26645808
https://pubmed.ncbi.nlm.nih.gov/26645808
Publikováno v:
Scientific Reports
Urea transporter B (UT-B) is a membrane channel protein that specifically transports urea. UT-B null mouse exhibited urea selective urine concentrating ability deficiency, which suggests the potential clinical applications of the UT-B inhibitors as n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24fa2ca2591085470024ef607de33f47
http://europepmc.org/articles/PMC5376056
http://europepmc.org/articles/PMC5376056
Autor:
Calvin Yu-Chian Chen, Weng Ieong Tou
Publikováno v:
Drug discovery today. 19(4)
Insomnia is a self-reported disease where patients lose their ability to initiate and maintain sleep, leading to daytime performance impairment. Several drug targets to ameliorate insomnia symptoms have been discovered; however, these drug targets le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d09e4652a222927ad3a6046e670bfa0
https://pubmed.ncbi.nlm.nih.gov/24184432
https://pubmed.ncbi.nlm.nih.gov/24184432
Autor:
Calvin Yu-Chian Chen, Weng Ieong Tou
Publikováno v:
Drug discovery today. 18(19-20)
Structural disorders of proteins make drug design a difficult task. The gel-like state of intrinsically disordered protein (IDP) or intrinsically disordered regions (IDRs) remains a big puzzle for drug designers. Here, we propose a novel concept for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bba8eddcd5ba9d20d0662feb9fe235a
https://pubmed.ncbi.nlm.nih.gov/23643489
https://pubmed.ncbi.nlm.nih.gov/23643489
Autor:
Calvin Yu-Chian Chen, Weng Ieong Tou
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 3, p e33728 (2012)
PLoS ONE, Vol 7, Iss 3, p e33728 (2012)
Src kinase is an attractive target for drug development based on its established relationship with cancer and possible link to hypertension. The suitability of traditional Chinese medicine (TCM) compounds as potential drug ligands for further biologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75180f2c312be58a5aafca0d9cd39b30
https://pubmed.ncbi.nlm.nih.gov/22470466
https://pubmed.ncbi.nlm.nih.gov/22470466