Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Weng Hua Khoo"'
Autor:
Qihao Ren, Weng Hua Khoo, Alexander P. Corr, Tri Giang Phan, Peter I. Croucher, Sheila A. Stewart
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-16 (2022)
Abstract Background Breast cancer can recur months to decades after an initial diagnosis and treatment. The mechanisms that control tumor cell dormancy remain poorly understood, making it difficult to predict which patients will recur and thus benefi
Externí odkaz:
https://doaj.org/article/22152aae55594e4188f347c69ed564c0
Autor:
Chansavath Phetsouphanh, Weng Hua Khoo, Katherine Jackson, Vera Klemm, Annett Howe, Anupriya Aggarwal, Anouschka Akerman, Vanessa Milogiannakis, Alberto Ospina Stella, Romain Rouet, Peter Schofield, Megan L. Faulks, Hannah Law, Thidarat Danwilai, Mitchell Starr, C. Mee Ling Munier, Daniel Christ, Mandeep Singh, Peter I. Croucher, Fabienne Brilot-Turville, Stuart Turville, Tri Giang Phan, Gregory J. Dore, David Darley, Philip Cunningham, Gail V. Matthews, Anthony D. Kelleher, John J. Zaunders
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundLong-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden.MethodsWe have investigated the ass
Externí odkaz:
https://doaj.org/article/54f0e1950fa84edf8548d013da07f7a4
Autor:
Imogen Moran, Akira Nguyen, Weng Hua Khoo, Danyal Butt, Katherine Bourne, Clara Young, Jana R. Hermes, Maté Biro, Gary Gracie, Cindy S. Ma, C. Mee Ling Munier, Fabio Luciani, John Zaunders, Andrew Parker, Anthony D. Kelleher, Stuart G. Tangye, Peter I. Croucher, Robert Brink, Mark N. Read, Tri Giang Phan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties
Externí odkaz:
https://doaj.org/article/434c7143b0dc490799e9dd7d746d107f
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Single-cell RNA sequencing (scRNA-Seq) is transforming our ability to characterize cells, particularly rare cells that are often overlooked in bulk population analytical approaches. This has lead to the discovery of new cell types and cellular states
Externí odkaz:
https://doaj.org/article/bbaec0f200714620a86e8db3b614ec69
Autor:
Weng Hua Khoo, Katherine Jackson, Chansavath Phetsouphanh, John J. Zaunders, José Alquicira-Hernandez, Seyhan Yazar, Stephanie Ruiz-Diaz, Mandeep Singh, Rama Dhenni, Wunna Kyaw, Fiona Tea, Vera Merheb, Fiona X. Z. Lee, Rebecca Burrell, Annaleise Howard-Jones, Archana Koirala, Li Zhou, Aysen Yuksel, Daniel R. Catchpoole, Catherine L. Lai, Tennille L. Vitagliano, Romain Rouet, Daniel Christ, Benjamin Tang, Nicholas P. West, Shane George, John Gerrard, Peter I. Croucher, Anthony D. Kelleher, Christopher G. Goodnow, Jonathan D. Sprent, Joseph D. Powell, Fabienne Brilot, Ralph Nanan, Peter S. Hsu, Elissa K. Deenick, Philip N. Britton, Tri Giang Phan
SUMMARYChildren infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a44cfb788a9ec10e32602c827e7e9bf
https://hdl.handle.net/2123/28409
https://hdl.handle.net/2123/28409
Autor:
Weng Hua Khoo, Katherine Jackson, Chansavath Phetsouphanh, John J. Zaunders, José Alquicira-Hernandez, Seyhan Yazar, Stephanie Ruiz-Diaz, Mandeep Singh, Rama Dhenni, Wunna Kyaw, Fiona Tea, Vera Merheb, Fiona X.Z. Lee, Rebecca Burrell, Annaleise Howard-Jones, Archana Koirala, Li Zhou, Aysen Yuksel, Daniel R. Catchpoole, Catherine L. Lai, Tennille L. Vitagliano, Romain Rouet, Daniel Christ, Benjamin Tang, Nicholas P. West, Shane George, John Gerrard, Peter I. Croucher, Anthony D. Kelleher, Christopher G. Goodnow, Jonathan D. Sprent, Joseph E. Powell, Fabienne Brilot, Ralph Nanan, Peter S. Hsu, Elissa K. Deenick, Philip N. Britton, Tri Giang Phan
Publikováno v:
Clinical Immunology. 246:109209
Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infection-induced immuni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38bc0d4e3b77dac5d4a0f0d818381fdb
https://doi.org/10.1016/j.clim.2022.109209
https://doi.org/10.1016/j.clim.2022.109209
Publikováno v:
Cancer Research. 82:2450-2450
Unfortunately, breast cancer can recur in patients upwards of 25 years after an initial diagnosis and “cure”. It was once thought that recurrence occurred within patients that harbored dormant breast disseminated tumor cells (DTCs) in distant org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d9f61071d65431d2bb7bc3acabf086
https://doi.org/10.1158/1538-7445.am2022-2450
https://doi.org/10.1158/1538-7445.am2022-2450
Autor:
Alex Spurling, John M. Mariadason, Lisa M. Butler, Linden J. Gearing, Niall M. Corcoran, Stefano Mangiola, Katie L. Owen, Peter I. Croucher, Natasha K Brockwell, Daniel L. Roden, Alexander Swarbrick, Ruth J. Lyons, Weng Hua Khoo, Matthew K.H. Hong, Anupama Pasam, Chia Ling Chan, Andrew Ryan, Michelle M. McDonald, Vanessa M. Hayes, Hendrika M. Duivenvoorden, Tri Giang Phan, Damien Zanker, Paul J. Hertzog, Shahneen Sandhu, Christopher M. Hovens, Marek Cmero, Belinda S. Parker
Publikováno v:
EMBO Reports
The latency associated with bone metastasis emergence in castrate‐resistant prostate cancer is attributed to dormancy, a state in which cancer cells persist prior to overt lesion formation. Using single‐cell transcriptomics and ex vivo profiling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1e84dc3ba88b9fe110748c95dfd5f9
Autor:
Roger S. Lasken, Tuan V. Nguyen, Babatunde O. Oyajobi, Ryan C. Chai, Weng Hua Khoo, Khatora S. Opperman, Guy Ledergor, Katie L. Owen, Christine Seeliger, Alexander Swarbrick, Peter I. Croucher, Dirk Hose, Duncan R. Hewett, Akira Nguyen, Ido Amit, Justine R. Clark, Nataša Kovačić, Michelle M. McDonald, Kim De Veirman, Alexander P. Corr, Assaf Weiner, Rachael L. Terry, Andrew C.W. Zannettino, Tri Giang Phan, Kate Vandyke, Anja Seckinger, Daniel L. Roden, Belinda S. Parker, Dana T. Aftab, Ya Xiao, Jessica A. Pettitt, Karin Vanderkerken, Mark Novotny, Sindhu T. Mohanty
The era of targeted therapies has seen significant improvements in depth of response, progression-free survival, and overall survival for patients with multiple myeloma. Despite these improvements in clinical outcome, patients inevitably relapse and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef7864fc479002428772b21d5df78c9
https://hdl.handle.net/10453/134791
https://hdl.handle.net/10453/134791
Autor:
Ryan C. Chai, Tri Giang Phan, Qihao Ren, Sheila A. Stewart, Alex Corr, Peter I. Croucher, James R. Smith, Weng Hua Khoo, Paul A. Baldock, Michelle M. McDonald
Publikováno v:
Cancer Research. 81:IA015-IA015
Dormancy is an elusive and deadly component of cancers. Rare, therapy resistant cells lay dormant for decades and when reactivated cause disease progression and relapse. Eradicating dormant cancer cells is key to curing cancers yet is an unrealized g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ca281d42d98ef4e8bf451faec2380ad
https://doi.org/10.1158/1538-7445.tme21-ia015
https://doi.org/10.1158/1538-7445.tme21-ia015