Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Wenfan Ke"'
Publikováno v:
eLife, Vol 13 (2024)
The chromosomes in multicellular eukaryotes are organized into a series of topologically independent loops called TADs. In flies, TADs are formed by physical interactions between neighboring boundaries. Fly boundaries exhibit distinct partner prefere
Externí odkaz:
https://doaj.org/article/9427adb529d84547857897ac73cfdcf2
Autor:
Xinyang Bing, Wenfan Ke, Miki Fujioka, Amina Kurbidaeva, Sarah Levitt, Mike Levine, Paul Schedl, James B Jaynes
Publikováno v:
eLife, Vol 13 (2024)
Two different models have been proposed to explain how the endpoints of chromatin looped domains (‘TADs’) in eukaryotic chromosomes are determined. In the first, a cohesin complex extrudes a loop until it encounters a boundary element roadblock,
Externí odkaz:
https://doaj.org/article/69f54650950e47cea510ecc8aa1663b4
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101956- (2023)
Summary: A major barrier to immunostaining Caenorhabditis elegans is the permeabilization of the worm's cuticle without distorting or damaging its body. We present here a gel-based immobilization protocol for fixed worms coupled with chemical and enz
Externí odkaz:
https://doaj.org/article/47d3610a0b0c469d9ffc617959ce4606
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 7, p e1010295 (2022)
The concept of "housekeeping gene" has been used for four decades but remains loosely defined. Housekeeping genes are commonly described as "essential for cellular existence regardless of their specific function in the tissue or organism", and "stabl
Externí odkaz:
https://doaj.org/article/427b3e577d694634be26acfd89426dff
Autor:
Wenfan Ke, James A. Saba, Cong-Hui Yao, Michael A. Hilzendeger, Anna Drangowska-Way, Chintan Joshi, Vinod K. Mony, Shawna B. Benjamin, Sisi Zhang, Jason Locasale, Gary J. Patti, Nathan Lewis, Eyleen J. O’Rourke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
The gut microbiota can alter the effects of anticancer fluoropyrimidines such as 5-fluorodeoxyuridine (FUdR) in the model organism C. elegans. Here, the authors show that these effects are further affected by diet, and dietary thymidine and serine in
Externí odkaz:
https://doaj.org/article/087ce5c3356748578c51b823b74c950a
Autor:
Wenfan Ke, Jordan N Reed, Chenyu Yang, Noel Higgason, Leila Rayyan, Carolina Wählby, Anne E Carpenter, Mete Civelek, Eyleen J O'Rourke
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009736 (2021)
Obesity and its associated metabolic syndrome are a leading cause of morbidity and mortality. Given the disease's heavy burden on patients and the healthcare system, there has been increased interest in identifying pharmacological targets for the tre
Externí odkaz:
https://doaj.org/article/ca9c57c357704cf4bc78b298a45d7a47
Autor:
Lacy J. Barton, Tingting Duan, Wenfan Ke, Amy Luttinger, Kaylee E. Lovander, Alexey A. Soshnev, Pamela K. Geyer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediate
Externí odkaz:
https://doaj.org/article/77f7379f13f0473c98fba6ad22b1aa9d
Autor:
Nathan E. Lewis, Anna Drangowska-Way, Eyleen J. O’Rourke, Michael A Hilzendeger, Chintan Joshi, James A Saba, Jason W. Locasale, Sisi Zhang, Cong-Hui Yao, Wenfan Ke, Vinod K. Mony, Shawna B Benjamin, Gary J. Patti
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
The gut microbiota metabolizes drugs and alters their efficacy and toxicity. Diet alters drugs, the metabolism of the microbiota, and the host. However, whether diet-triggered metabolic changes in the microbiota can alter drug responses in the host h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd16d1115cc2ad2bbd5fcd991b6d977
https://doaj.org/article/087ce5c3356748578c51b823b74c950a
https://doaj.org/article/087ce5c3356748578c51b823b74c950a
Publikováno v:
Joshi, C J, Ke, W, Drangowska-Way, A, O’Rourke, E J & Lewis, N E 2022, ' What are housekeeping genes? ', PLOS Computational Biology, vol. 18, no. 7, e1010295 . https://doi.org/10.1371/journal.pcbi.1010295
PLoS computational biology, vol 18, iss 7
PLoS computational biology, vol 18, iss 7
Two gene classes that have proven useful in understanding the phenotypic states of cells are housekeeping genes and essential genes. Housekeeping genes are often defined as stably expressed in mRNA expression experiments, as essential for cellular ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ab0d364cb22fa995f2291a73d3c1da
https://orbit.dtu.dk/en/publications/914594fa-47f6-47ab-89c2-24076a6d3c47
https://orbit.dtu.dk/en/publications/914594fa-47f6-47ab-89c2-24076a6d3c47
Autor:
Eyleen J. O’Rourke, Réka Albert, Mary Kate Horak, Abbas Ghaddar, Wenfan Ke, Vinod K. Mony, Emma Harrison, Anna Drangowska-Way
Publikováno v:
Proc Natl Acad Sci U S A
Plasticity in multicellular organisms involves signaling pathways converting contexts—either natural environmental challenges or laboratory perturbations—into context-specific changes in gene expression. Congruently, the interactions between the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523cb63e9722a1fba256ba934dcff895
https://doi.org/10.1073/pnas.2104832118
https://doi.org/10.1073/pnas.2104832118