Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Wener Li"'
Publikováno v:
Stem Cell Research, Vol 56, Iss , Pp 102565- (2021)
Recently, there have been great advances in cardiovascular channelopathy modeling and drug safety pharmacology using human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). The automated patch-clamp (APC) technique overcomes the disadv
Externí odkaz:
https://doaj.org/article/7887c497b2d548b08bc98d7f4f99e75b
Autor:
Wener Li, Sarah Henze, Xiaojing Luo, Ying Ulbricht, Anja Richter, Nataliya Di Donato, Arthur A.M. Wilde, Kaomei Guan
Publikováno v:
Stem Cell Research, Vol 53, Iss , Pp 102259- (2021)
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe inheritable cardiac disorder, which is characterized by life-threatening cardiac arrhythmias, syncope, seizures, or sudden cardiac death in response to physical exercise or emot
Externí odkaz:
https://doaj.org/article/689c830c4748464aa6af631e5412e926
Autor:
Wener Li, Michael Stauske, Xiaojing Luo, Stefan Wagner, Meike Vollrath, Carola S. Mehnert, Mario Schubert, Lukas Cyganek, Simin Chen, Sayed-Mohammad Hasheminasab, Gerald Wulf, Ali El-Armouche, Lars S. Maier, Gerd Hasenfuss, Kaomei Guan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Brugada syndrome (BrS) is one of the major causes of sudden cardiac death in young people, while the underlying mechanisms are not completely understood. Here, we investigated the pathophysiological phenotypes and mechanisms using induced pluripotent
Externí odkaz:
https://doaj.org/article/67390607ff314c6cac21aee37e21a20f
Autor:
Xiaojing Luo, Wener Li, Karolina Künzel, Sarah Henze, Lukas Cyganek, Anna Strano, Mareike S. Poetsch, Mario Schubert, Kaomei Guan
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
In adult cardiomyocytes (CMs), the type 2 ryanodine receptor (RYR2) is an indispensable Ca2+ release channel that ensures the integrity of excitation-contraction coupling, which is fundamental for every heartbeat. However, the role and importance of
Externí odkaz:
https://doaj.org/article/f553e500221045f0aa217679c387b205
Autor:
Wener Li, Xiaojing Luo, Mareike S. Poetsch, Reinhard Oertel, Kapil Nichani, Martin Schneider, Anna Strano, Marcel Hasse, Robert-Patrick Steiner, Lukas Cyganek, Karina Hettwer, Steffen Uhlig, Kirsten Simon, Kaomei Guan, Mario Schubert
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 220 (2022)
Adverse effects of drug combinations and their underlying mechanisms are highly relevant for safety evaluation, but often not fully studied. Hydroxychloroquine (HCQ) and azithromycin (AZM) were used as a combination therapy in the treatment of COVID-
Externí odkaz:
https://doaj.org/article/b58f02bdcb5c4b80bfbe8c19116f2fa7
Autor:
Wener Li, Xiaojing Luo, Ying Ulbricht, Michael Wagner, Christopher Piorkowski, Ali El-Armouche, Kaomei Guan
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies and for drug safety pharmacology. However, the electrophysiological and pharmac
Externí odkaz:
https://doaj.org/article/05444fd556fe4e3eba4a081cd8dd1b2b
Autor:
Suzan J. G. Knottnerus, Isabella Mengarelli, Rob C. I. Wüst, Antonius Baartscheer, Jeannette C. Bleeker, Ruben Coronel, Sacha Ferdinandusse, Kaomei Guan, Lodewijk IJlst, Wener Li, Xiaojing Luo, Vincent M. Portero, Ying Ulbricht, Gepke Visser, Ronald J. A. Wanders, Frits A. Wijburg, Arie O. Verkerk, Riekelt H. Houtkooper, Connie R. Bezzina
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7, p 2589 (2020)
Patients with very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) can present with life-threatening cardiac arrhythmias. The pathophysiological mechanism is unknown. We reprogrammed fibroblasts from one mildly and one severely affected VLCADD
Externí odkaz:
https://doaj.org/article/9291905b068a4faa9e19d8a94197632a
Autor:
Lukas Cyganek, Steffen Uhlig, Karina Hettwer, Anna Strano, Wener Li, Kapil Nichani, Xiaojing Luo, Robert Patrick Steiner, Martin F. Schneider, Mario Schubert, Kaomei Guan, Kirsten Simon, Mareike S. Poetsch, Marcel Hasse, Reinhard Oertel
Despite known adverse effects of hydroxychloroquine (HCQ) and azithromycin (AZM) on cardiac function, HCQ and AZM have been used as combination therapy in the treatment of COVID-19 patients. Recent clinical data indicate higher complication rates wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::568f8f67f98434fc4364469a06a3201a
https://doi.org/10.1101/2021.08.19.456950
https://doi.org/10.1101/2021.08.19.456950
Autor:
Erich Wettwer, Katharina Metzner, Torsten Christ, Michael Schaefer, Ali El-Armouche, Dobromir Dobrev, Susanne Kämmerer, Stephan R Künzel, Fabian Belau, Ursula Ravens, Wener Li
Publikováno v:
International Journal of Cardiology. 284:68-73
Background Cardiac accessory β-subunits are part of macromolecular Nav1.5 channel complexes modulating biophysical properties and contributing to arrhythmias. Recent studies demonstrated the structural interaction between β-subunits of Na+ (Nav1.5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2eda91c19f02bf3c87abeb94fc0474
https://doi.org/10.1016/j.ijcard.2018.12.072
https://doi.org/10.1016/j.ijcard.2018.12.072
Autor:
Frits A. Wijburg, Connie R. Bezzina, Suzan J. G. Knottnerus, Xiaojing Luo, Antonius Baartscheer, Kaomei Guan, Wener Li, Sacha Ferdinandusse, Ronald J.A. Wanders, Ying Ulbricht, Rob C. I. Wüst, Riekelt H. Houtkooper, Isabella Mengarelli, Gepke Visser, Ruben Coronel, Vincent Portero, Jeannette C. Bleeker, Lodewijk IJlst, Arie O. Verkerk
Publikováno v:
International journal of molecular sciences, 21(7):2589. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 21, Iss 2589, p 2589 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 7
International Journal of Molecular Sciences, Vol 21, Iss 2589, p 2589 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 7
Patients with very long-chain acyl-CoA dehydrogenase deficiency (VLCADD) can present with life-threatening cardiac arrhythmias. The pathophysiological mechanism is unknown. We reprogrammed fibroblasts from one mildly and one severely affected VLCADD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1048994c1c7de653958d78caa5e5c907
https://pure.amc.nl/en/publications/electrophysiological-abnormalities-in-vlcad-deficient-hipsccardiomyocytes-can-be-improved-by-lowering-accumulation-of-fatty-acid-oxidation-intermediates(7408927f-4407-47ac-bfe0-fd5a7be0c915).html
https://pure.amc.nl/en/publications/electrophysiological-abnormalities-in-vlcad-deficient-hipsccardiomyocytes-can-be-improved-by-lowering-accumulation-of-fatty-acid-oxidation-intermediates(7408927f-4407-47ac-bfe0-fd5a7be0c915).html