Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Wendy Wen Yi Leong"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3945-3948
C2-symmetric diols have been shown to be highly potent against HIV-1 protease (PR). However, gaining access to these compounds has been hampered by the need of multistep solution-phase reactions which are often tedious and inefficient. In this Letter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002c6ffc165fd4d9f38237072b8010d0
https://doi.org/10.1016/j.bmcl.2009.03.041
https://doi.org/10.1016/j.bmcl.2009.03.041
Publikováno v:
The Journal of Organic Chemistry. 74:2854-2857
The homoallyl moiety, (h)Allyl, is presented as a general protecting group for several functionalities. It can be chemoselectively removed via a sequential, one-pot cross-metathesis/elimination sequence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4e5165f6c2c28d5e33d1056cf3551ef
https://doi.org/10.1021/jo900012z
https://doi.org/10.1021/jo900012z
Publikováno v:
International Journal of Pharmaceutics. 341:238-245
13- cis -Retinoic acid (13- cis -RA), also known as isotretinoin, is commonly used in the management of severe acne. Its clinical efficacy in oncology has also been documented. As a vitamin A derivative, it is not soluble in water. This solubility ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b848e48a6077214774e08d2b6839392a
https://doi.org/10.1016/j.ijpharm.2007.03.050
https://doi.org/10.1016/j.ijpharm.2007.03.050
Autor:
Wei Chen, Runyan Ni, Amylia Bte Abdul Ghani, Huaqiang Zeng, Dejian Huang, Caili Fu, Wendy Wen Yi Leong, Yi Ling Quek
Publikováno v:
Tetrahedron Letters. 51:6322-6324
Oligomeric proanthocyanidins (OPCs, Ar′ = 3,4-(HO) 2 (C 6 H 3 ) are abundant natural products found in agricultural and forestry waste such as pine bark, grape seeds, and the peels of mangosteen. We have demonstrated that the OPCs can be converted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16cf09f637687c2eb62960a0a6301a86
https://doi.org/10.1016/j.tetlet.2010.09.123
https://doi.org/10.1016/j.tetlet.2010.09.123
Publikováno v:
ChemInform. 44
The NHC-catalyzed reaction of enals (I) with chalcones (II) in water leads to trisubstituted cyclopentenes (III).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a741dc7f66f921687bdd213a0bbcddb
https://doi.org/10.1002/chin.201340091
https://doi.org/10.1002/chin.201340091
Publikováno v:
ChemInform. 44
Conjugate addition reactions to enones can now be done in water at room temperature with in situ generated organocopper reagents. Mixing an enone, zinc powder, TMEDA, and an alkyl halide in a micellar environemnt containing catalytic amounts of Cu(I)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04c8b63bb15c68f39906073142707cc9
https://doi.org/10.1002/chin.201322040
https://doi.org/10.1002/chin.201322040
Publikováno v:
ChemInform. 44
In the presence of catalytic amounts of PPh3 and p-methoxyphenol, N-sulfonyl-1-aza-1,3-dienes undergo the title reaction with vinyl ketones to give the isolated pyridine derivatives exclusively as trans-isomers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c16ceda6ea8956d8a226f8580eb75e27
https://doi.org/10.1002/chin.201303135
https://doi.org/10.1002/chin.201303135
Autor:
Wendy Wen Yi. Leong
The work described in this thesis is devoted to the development of environmentally benign organo- and metal-catalyzed reactions through the use of water as the solvent. With the use of a “designer surfactant”, TPGS-750-M, copper-catalyzed conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::935100550706c4d5f68e7d54b07d318f
https://hdl.handle.net/10356/54854
https://hdl.handle.net/10356/54854
Water is demonstrated as a suitable solvent for NHC-catalyzed reactions of enals. The use of D2O as a solvent allows for the effective incorporation of deuterium isotopes into organic molecules.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fab8a058aa7e56d16b09b139ea7433
http://hdl.handle.net/10220/19447
http://hdl.handle.net/10220/19447
Publikováno v:
ChemInform. 43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c6509ea23a09fbb9cf0da09316dc6f
https://doi.org/10.1002/chin.201224092
https://doi.org/10.1002/chin.201224092