Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Wendy W J de Leng"'
Autor:
Rixt S. Bruinsma, Marta F. Fiocco, Wendy W. J. de Leng, Lennart A. Kester, Karin P. S. Langenberg, Godelieve A. M. Tytgat, Max M. van Noesel, Marc H. W. A. Wijnen, Alida F. W. van der Steeg, Ronald R. de Krijger
Publikováno v:
Journal of Molecular Pathology, Vol 5, Iss 3, Pp 304-318 (2024)
ALK is related to poor survival in neuroblastoma patients. We investigated the prognostic relevance of ALK mRNA expression and the relationship with ALK immunohistochemical expression, histological subtype and ALK aberrations. Whole transcriptome seq
Externí odkaz:
https://doaj.org/article/7650c5ee68724d7986d26e5dc5cc04ca
Autor:
Wendy W J de Leng, Christa G Gadellaa-van Hooijdonk, Françoise A S Barendregt-Smouter, Marco J Koudijs, Ies Nijman, John W J Hinrichs, Edwin Cuppen, Stef van Lieshout, Robert D Loberg, Maja de Jonge, Emile E Voest, Roel A de Weger, Neeltje Steeghs, Marlies H G Langenberg, Stefan Sleijfer, Stefan M Willems, Martijn P Lolkema
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149405 (2016)
Targeted Next Generation Sequencing (NGS) offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is necessary for personalized cancer treatment. However, no standards regarding input material have be
Externí odkaz:
https://doaj.org/article/d24f1077607043a59bda3a036165608a
Autor:
Birgit S. Geurts, Thomas W. Battaglia, J. Maxime van Berge Henegouwen, Laurien J. Zeverijn, Gijs F. de Wit, Louisa R. Hoes, Hanneke van der Wijngaart, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Frans L. Opdam, Maja J. A. de Jonge, Geert A. Cirkel, Mariette Labots, Ann Hoeben, Emile D. Kerver, Adriaan D. Bins, Frans G.L. Erdkamp, Johan M. van Rooijen, Danny Houtsma, Mathijs P. Hendriks, Jan-Willem B. de Groot, Henk M. W. Verheul, Hans Gelderblom, Emile E. Voest
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023)
Abstract Background In this study we aimed to evaluate the efficacy and safety of the PD-L1 inhibitor durvalumab across various mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) tumours in the Drug Rediscovery Protocol (DRUP
Externí odkaz:
https://doaj.org/article/0e6af27c660548eab8d0d86d81fe251d
Autor:
Lieke M. J. van Zogchel, Nathalie S. M. Lak, Nina U. Gelineau, Irina Sergeeva, Ellen Stelloo, Joost Swennenhuis, Harma Feitsma, Max van Min, Erik Splinter, Margit Bleijs, Marian Groot Koerkamp, Willemijn Breunis, Michael Torsten Meister, Waleed Hassan Kholossy, Frank C. P. Holstege, Jan J. Molenaar, Wendy W. J. de Leng, Janine Stutterheim, C. Ellen van der Schoot, Godelieve A. M. Tytgat
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundLiquid biopsies combine minimally invasive sample collection with sensitive detection of residual disease. Pediatric malignancies harbor tumor-driving copy number alterations or fusion genes, rather than recurrent point mutations. These reg
Externí odkaz:
https://doaj.org/article/7b442cccd01346f9baef8bf01b4fb357
Autor:
Shivanand O. Richardson, Manon M. H. Huibers, Roel A. de Weger, Wendy W. J. de Leng, John W. J. Hinrichs, Ruud W. J. Meijers, Stefan M. Willems, Ton L. M. G. Peeters
Publikováno v:
Molecular Cytogenetics, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background The Fluorescence In Situ Hybridization (FISH) technique is a very useful tool for diagnostic and prognostic purposes in molecular pathology. However, clinical testing on patient tissue is challenging due to variables of tissue pro
Externí odkaz:
https://doaj.org/article/95496c3b8ec54bfa951f5d85ad793295
Autor:
Wendy W J de Leng, Marijke R. van Dijk, Nadege C van Varsseveld, Paul J. van Diest, Nikolas Stathonikos, Roel Goldschmeding, C. Vreuls, Miangela M Lacle, Tri Q. Nguyen, Aryan Vink
Publikováno v:
Journal of Clinical Pathology
The 2020 COVID-19 crisis has had and will have many implications for healthcare, including pathology. Rising number of infections create staffing shortages and other hospital departments might require pathology employees to fill more urgent positions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba3253f50fc6f3cb6a374a9d61b37ec
https://doi.org/10.1136/jclinpath-2020-206845
https://doi.org/10.1136/jclinpath-2020-206845
Autor:
Chiel F, Ebbelaar, Anne M R, Schrader, Marijke, van Dijk, Ruud W J, Meijers, Wendy W J, de Leng, Lourens T, Bloem, Anne M L, Jansen, Willeke A M, Blokx
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 35(8)
Cutaneous deep penetrating melanocytic neoplasms frequently simulate melanoma and might occasionally progress to metastatic melanoma. Distinguishing deep penetrating nevi (DPN) and deep penetrating melanocytomas (DPM) from malignant deep penetrating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41df0cd2c6811dec68305b655d4e4879
https://pubmed.ncbi.nlm.nih.gov/35184152
https://pubmed.ncbi.nlm.nih.gov/35184152
Autor:
Valentyna, Kryklyva, Nadia, Haj Mohammad, Folkert H M, Morsink, Marjolijn J L, Ligtenberg, G Johan A, Offerhaus, Iris D, Nagtegaal, Wendy W J, de Leng, Lodewijk A A, Brosens
Publikováno v:
Cancer Biology & Therapy
Acinar cell carcinoma (ACC) is a rare pancreatic neoplasm with dismal prognosis. Insights into the molecular basis of ACC can pave the way for the application of more effective, personalized therapies and detection of patients with hereditary predisp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e52fc7340f965c1651e4c5adad3d83d7
https://pubmed.ncbi.nlm.nih.gov/31002019
https://pubmed.ncbi.nlm.nih.gov/31002019
Autor:
Eric, Strengman, Francoise A S, Barendrecht-Smouter, Carmen, de Voijs, Paula, de Vree, Isaac J, Nijman, Wendy W J, de Leng
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1908
Next-generation sequencing (NGS) is rapidly becoming the method of choice for mutation analysis in both research and diagnostics. The benefit of targeted NGS compared to whole-genome and whole-exome sequencing is that smaller amounts of input materia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4c6c4731cccfc6318be6c3075cd87d1
https://pubmed.ncbi.nlm.nih.gov/30649717
https://pubmed.ncbi.nlm.nih.gov/30649717
Publikováno v:
Journal of Gastroenterology, 51(9), 841–852. Springer Japan
Journal of Gastroenterology
Journal of Gastroenterology
Colorectal carcinogenesis is a process that follows a stepwise cascade that goes from the normal to an invisible pretumor stage ultimately leading to grossly visible tumor progression. During pretumor progression, an increasing accumulation of geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4495bdaf16045a12562936bb4632893a
https://doi.org/10.1007/s00535-016-1211-3
https://doi.org/10.1007/s00535-016-1211-3