Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Wendy V. Gilbert"'
Autor:
Swapnil C. Devarkar, Michael Vetick, Shravani Balaji, Ivan B. Lomakin, Luojia Yang, Danni Jin, Wendy V. Gilbert, Sidi Chen, Yong Xiong
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113156- (2023)
Summary: All betacoronaviruses (β-CoVs) encode non-structural protein 1 (Nsp1), an essential pathogenicity factor that potently restricts host gene expression. Among the β-CoV family, MERS-CoV is the most distantly related member to SARS-CoV-2, and
Externí odkaz:
https://doaj.org/article/ea492ca260034be5a86d60d71e01573b
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101862- (2022)
Summary: Direct analysis of ribosome targeting (DART) allows investigators to measure the translation initiation potential of thousands of RNAs in parallel. Here, we describe an optimized protocol for generating active translation extract from S. cer
Externí odkaz:
https://doaj.org/article/af981bb5ca9f45f6927277ea97495b77
Autor:
Austin S. Draycott, Cassandra Schaening-Burgos, Maria F. Rojas-Duran, Loren Wilson, Leonard Schärfen, Karla M. Neugebauer, Sigrid Nachtergaele, Wendy V. Gilbert
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
Dihydrouridine is a modified nucleotide universally present in tRNAs, but the complete dihydrouridine landscape is unknown in any organism. We introduce dihydrouridine sequencing (D-seq) for transcriptome-wide mapping of D with single-nucleotide reso
Externí odkaz:
https://doaj.org/article/cc529fc7d66c41c0bd44aeb22d3d881d
Autor:
Wendy V. Gilbert, Sigrid Nachtergaele
Publikováno v:
Annual Review of Biochemistry. 92
Chemical modifications on mRNA represent a critical layer of gene expression regulation. Research in this area has continued to accelerate over the last decade, as more modifications are being characterized with increasing depth and breadth. mRNA mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc206753d4924de760d81552bb8e98a7
https://doi.org/10.1146/annurev-biochem-052521-035949
https://doi.org/10.1146/annurev-biochem-052521-035949
Autor:
Sonya Neal, Fumiaki Ohtake, Ana Maria Cuervo, Ramanujan S. Hegde, Ursula Jakob, Michael Lazarou, Wendy V. Gilbert, Zhijian J. Chen, Sharon A. Tooze, James E. Haber, Kylie J. Walters, F. Ulrich Hartl
Publikováno v:
Molecular Cell. 82:1390-1397
We asked experts from different fields-from genome maintenance and proteostasis to organelle degradation via ubiquitin and autophagy-"What does quality control mean to you?" Despite their diverse backgrounds, they converge on and discuss the importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8665058e173c05f48b569a518e81e83
https://doi.org/10.1016/j.molcel.2022.04.002
https://doi.org/10.1016/j.molcel.2022.04.002
Autor:
Meaghan C S Courvan, Rachel O Niederer, Isaac W Vock, Lea Kiefer, Wendy V Gilbert, Matthew D Simon
Publikováno v:
Nucleic acids research. 50(19)
Quantitative comparisons of RNA levels from different samples can lead to new biological understanding if they are able to distinguish biological variation from variable sample preparation. These challenges are pronounced in comparisons that require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd58ecacb06a3ee9cc4b87b8f52adce
https://pubmed.ncbi.nlm.nih.gov/36018791
https://pubmed.ncbi.nlm.nih.gov/36018791
Autor:
Douglas J Cattie, Claire E Richardson, Kirthi C Reddy, Elan M Ness-Cohn, Rita Droste, Mary K Thompson, Wendy V Gilbert, Dennis H Kim
Publikováno v:
PLoS Genetics, Vol 12, Iss 9, p e1006326 (2016)
The translation initiation factor eIF3 is a multi-subunit protein complex that coordinates the assembly of the 43S pre-initiation complex in eukaryotes. Prior studies have demonstrated that not all subunits of eIF3 are essential for the initiation of
Externí odkaz:
https://doaj.org/article/945edc35e80548d9a13d3b939a1dbfdf
Publikováno v:
eLife, Vol 5 (2016)
Translation is a core cellular process carried out by a highly conserved macromolecular machine, the ribosome. There has been remarkable evolutionary adaptation of this machine through the addition of eukaryote-specific ribosomal proteins whose indiv
Externí odkaz:
https://doaj.org/article/f9be7e3a161445d88edce4101bb41ca2
Publikováno v:
Annu Rev Genet
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of noncoding RNA in human cells. The known molecular functions of pseudouridine, which include stabilizing RNA conform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5714b8168673a0cddae2f9df51d2c02
https://doi.org/10.1146/annurev-genet-112618-043830
https://doi.org/10.1146/annurev-genet-112618-043830
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation
Publikováno v:
Cell Syst
Translational control shapes the proteome in normal and pathophysiological conditions. Current high-throughput approaches reveal large differences in mRNA-specific translation activity but cannot identify the causative mRNA features. We developed dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d896707277ba3aacd95643c4123cf985
https://europepmc.org/articles/PMC8930539/
https://europepmc.org/articles/PMC8930539/
