Zobrazeno 1 - 10 of 66 pro vyhledávání: '"Wendy T. Watford"'
1
Akademický článek
Tumor Progression Locus 2 Protects against Acute Respiratory Distress Syndrome in Influenza A Virus-Infected Mice
Autor: Krishna Latha, Sanjana Rao, Kaori Sakamoto, Wendy T. Watford
Publikováno v: Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Excessive inflammation in patients with severe influenza disease may lead to acute lung injury that results in acute respiratory distress syndrome (ARDS). ARDS is associated with alveolar damage and pulmonary edema that severely impair gas e
Externí odkaz: https://doaj.org/article/70a6d14eeee34cc5b7768114305903de
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2
Akademický článek
Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection
Autor: Krishna Latha, Katelyn F. Jamison, Wendy T. Watford
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host re
Externí odkaz: https://doaj.org/article/6868df64b6104dada2d61d1b3763c951
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3
Akademický článek
CtpB Facilitates Mycobacterium tuberculosis Growth in Copper-Limited Niches
Autor: Oliver Shey-Njila, Ahmed F. Hikal, Tuhina Gupta, Kaori Sakamoto, Hind Yahyaoui Azami, Wendy T. Watford, Frederick D. Quinn, Russell K. Karls
Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 10, p 5713 (2022)
Copper is required for aerobic respiration by Mycobacterium tuberculosis and its human host, but this essential element is toxic in abundance. Copper nutritional immunity refers to host processes that modulate levels of free copper to alternately sta
Externí odkaz: https://doaj.org/article/a4c9715cc8f847f49998000a83e46133
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4
Akademický článek
Influenza-induced Tpl2 expression within alveolar epithelial cells is dispensable for host viral control and anti-viral immunity.
Autor: Kara D Wyatt, Demba Sarr, Kaori Sakamoto, Wendy T Watford
Publikováno v: PLoS ONE, Vol 17, Iss 1, p e0262832 (2022)
Tumor progression locus 2 (Tpl2) is a serine/threonine kinase that regulates the expression of inflammatory mediators in response to Toll-like receptors (TLR) and cytokine receptors. Global ablation of Tpl2 leads to severe disease in response to infl
Externí odkaz: https://doaj.org/article/30423a596fba41c198484813715f0e20
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5
Akademický článek
Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo.
Autor: Chris D Slade, Katie L Reagin, Hari G Lakshmanan, Kimberly D Klonowski, Wendy T Watford
Publikováno v: PLoS ONE, Vol 15, Iss 7, p e0235706 (2020)
During type 1 immune responses, CD4 T helper 1 (Th1) cells and CD8 T cells are activated via IL-12 and contribute to the elimination of intracellular pathogens through interferon gamma (IFNγ) production. In this study, we identified Placenta-specifi
Externí odkaz: https://doaj.org/article/a6a947c349de40db8c2307377d704983
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6
The Influenza-Induced Pulmonary Inflammatory Exudate in Susceptible Tpl2-Deficient Mice Is Dictated by Type I IFN Signaling
Autor: Krishna Latha, Yesha Patel, Sanjana Rao, Wendy T. Watford
Publikováno v: Inflammation. 46:322-341
The most prominent host response to viral infection is the production of type 1 interferons (T1 IFNs). One host regulator of the T1 IFNs is the serine-threonine kinase, tumor progression locus 2 (TPL2). We have previously demonstrated that Tpl2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dcaf7ae7025329d772ce20f421a20a
https://doi.org/10.1007/s10753-022-01736-8
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8
Tpl2 Ablation Leads to Hypercytokinemia and Excessive Cellular Infiltration to the Lungs During Late Stages of Influenza Infection
Autor: Wendy T. Watford, Krishna Latha, Katelyn F. Jamison
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Tumor progression locus 2 (Tpl2) is a serine-threonine kinase known to promote inflammation in response to various pathogen-associated molecular patterns (PAMPs), inflammatory cytokines and G-protein-coupled receptors and consequently aids in host re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f816d965eedc6a67164d1b569b6b29e2
https://doi.org/10.3389/fimmu.2021.738490
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9
Tamoxifen administration induces histopathologic changes within the lungs of cre-recombinase-negative mice: a case report
Autor: Wendy T. Watford, Kara D. Wyatt, Kaori Sakamoto
Publikováno v: Lab Anim
Tamoxifen is commonly used as a cancer treatment in humans and for inducing genetic alterations using Cre-lox mouse models in the research setting. However, the extent of tamoxifen off-target effects in animal research is underappreciated. Here, we r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6075ba52f6a0fc3e90f5ea8cfbc0c96
https://europepmc.org/articles/PMC9472673/
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10
Akademický článek
Tumor Progression Locus 2 Promotes Induction of IFNλ, Interferon Stimulated Genes and Antigen-Specific CD8+ T Cell Responses and Protects against Influenza Virus.
Autor: Teneema Kuriakose, Ralph A Tripp, Wendy T Watford
Publikováno v: PLoS Pathogens, Vol 11, Iss 8, p e1005038 (2015)
Mitogen-activated protein kinase (MAP) cascades are important in antiviral immunity through their regulation of interferon (IFN) production as well as virus replication. Although the serine-threonine MAP kinase tumor progression locus 2 (Tpl2/MAP3K8)
Externí odkaz: https://doaj.org/article/7f5c9a3c36224051a406cd22fce64eb1
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