Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wendy Scheveneels"'
Autor:
Silke Vanderhaeghe, Jovan Prerad, Arun Kumar Tharkeshwar, Elien Goethals, Katlijn Vints, Jimmy Beckers, Wendy Scheveneels, Eveline Debroux, Katrien Princen, Philip Van Damme, Marc Fivaz, Gerard Griffioen, Ludo Van Den Bosch
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Valosin-containing protein (VCP) is a ubiquitously expressed type II AAA+ ATPase protein, implicated in both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This study aimed to explore the impact of the disease-causing
Externí odkaz:
https://doaj.org/article/61150bce5793479d8f52cfb7b32a5e38
Autor:
Elke Bogaert, Steven Boeynaems, Masato Kato, Lin Guo, Thomas R. Caulfield, Jolien Steyaert, Wendy Scheveneels, Nathalie Wilmans, Wanda Haeck, Nicole Hersmus, Joost Schymkowitz, Frederic Rousseau, James Shorter, Patrick Callaerts, Wim Robberecht, Philip Van Damme, Ludo Van Den Bosch
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 529-537.e4 (2018)
Summary: RNA-binding protein aggregation is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To gain better insight into the molecular interact
Externí odkaz:
https://doaj.org/article/4c45c2f32f6344e9bdc9bf9b4b22882d
Autor:
Ludo Van Den Bosch, Erik Storkebaum, Vicky Vleminckx, Lieve Moons, Ludo Vanopdenbosch, Wendy Scheveneels, Peter Carmeliet, Wim Robberecht
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 1, Pp 21-28 (2004)
Both in mice and humans, low expression levels of vascular endothelial growth factor (VEGF) are linked to adult-onset motor neuron disease or amyotrophic lateral sclerosis (ALS). The mechanism through which reduced VEGF levels result in this phenotyp
Externí odkaz:
https://doaj.org/article/47c67457dd1f4d6299a83afc21036489
Autor:
Lin Guo, Nathalie Wilmans, Wendy Scheveneels, Frederic Rousseau, Ludo Van Den Bosch, Nicole Hersmus, Jolien Steyaert, Steven Boeynaems, Masato Kato, Patrick Callaerts, Wanda Haeck, Philip Van Damme, James Shorter, Elke Bogaert, Thomas R. Caulfield, Joost Schymkowitz, Wim Robberecht
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 529-537.e4 (2018)
Cell Reports
CELL REPORTS
Cell Reports
CELL REPORTS
Summary RNA-binding protein aggregation is a pathological hallmark of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). To gain better insight into the molecular interacti
Autor:
Philip Van Damme, Ludo Van Den Bosch, Joni Vanneste, Wendy Scheveneels, Patrick Callaerts, Wim Robberecht, Jolien Steyaert, Elke Bogaert
Publikováno v:
Human Molecular Genetics
HUMAN MOLECULAR GENETICS
HUMAN MOLECULAR GENETICS
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases characterized by the progressive loss of specific groups of neurons. Due to clinical, genetic and pathological overlap, both diseases are considered
Autor:
André Bento-Abreu, Mieke Timmers, Ludo Van Den Bosch, Tania F. Gendron, Philip Van Damme, Bart Swinnen, Rik Nuyts, Elke Bogaert, Sarah Mizielinska, Wendy Scheveneels, Leonard Petrucelli, Wim Robberecht, Adrian M. Isaacs, Nicole Hersmus, Steven Boeynaems, Jiou Wang, Robin Lemmens
Publikováno v:
ACTA NEUROPATHOLOGICA
Swinnen, B, Bento-Abreu, A, Gendron, T F, Boeynaems, S, Bogaert, E, Nuyts, R, Timmers, M, Scheveneels, W, Hersmus, N, Wang, J, Mizielinska, S, Isaacs, A M, Petrucelli, L, Lemmens, R, Van Damme, P, Van Den Bosch, L & Robberecht, W 2018, ' A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism ', Acta Neuropathologica, vol. 135, no. 3, pp. 427-443 . https://doi.org/10.1007/s00401-017-1796-5
Acta Neuropathologica
Swinnen, B, Bento-Abreu, A, Gendron, T F, Boeynaems, S, Bogaert, E, Nuyts, R, Timmers, M, Scheveneels, W, Hersmus, N, Wang, J, Mizielinska, S, Isaacs, A M, Petrucelli, L, Lemmens, R, Van Damme, P, Van Den Bosch, L & Robberecht, W 2018, ' A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism ', Acta Neuropathologica, vol. 135, no. 3, pp. 427-443 . https://doi.org/10.1007/s00401-017-1796-5
Acta Neuropathologica
The exact mechanism underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with the GGGGCC repeat expansion in C9orf72 is still unclear. Two gain-of-function mechanisms are possible: repeat RNA toxicity and dipept
Autor:
Constantin d’Ydewalle, Philip Van Damme, Wendy Scheveneels, Pieter Vanden Berghe, Lawrence Van Helleputte, Veronick Benoy, Wanda Haeck, Wim Robberecht, Begga Schevenels, Natasja Geens, Ludo Van Den Bosch, Alan P. Kozikowski, Kevin Talbot, M. Zameel Cader, Robert Prior
Publikováno v:
Brain
Patients with Charcot-Marie-Tooth disease with predominant axonal loss (CMT2) show extensive genetic heterogeneity. Benoy et al. demonstrate a link between CMT2 and histone deacetylase 6 (HDAC6), which controls the acetylation of α-tubulin, and prop
Autor:
Kevin J. Verstrepen, Philip Van Damme, Wim Robberecht, Ana Jovičić, Elke Bogaert, Greet De Baets, Anne Sieben, Ilse Gijselinck, Wendy Scheveneels, Emiel Michiels, Aaron D. Gitler, Marc Cruts, Ivy Cuijt, Frederic Rousseau, Christine Van Broeckhoven, Jolien Steyaert, Ludo Van Den Bosch, Steven Boeynaems, Patrick Callaerts, Joost Schymkowitz
Publikováno v:
Scientific Reports
Scientific reports
SCIENTIFIC REPORTS
Scientific reports
SCIENTIFIC REPORTS
Hexanucleotide repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) (c9ALS/FTD). Unconventional translation of these repeats produces dipeptide repeat proteins (DPRs) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07e982f5984976dda5c19fdfdf62545
https://lirias.kuleuven.be/handle/123456789/531641
https://lirias.kuleuven.be/handle/123456789/531641
Autor:
Rene Verbesselt, Wendy Scheveneels, Kim A. Staats, L. Van Den Bosch, Wim Robberecht, M. Van Rillaer, P. Van Damme
Publikováno v:
Neuroscience. 220:26-31
Amyotrophic Lateral Sclerosis (ALS) is a devastating progressive neurodegenerative disease. One of the proposed disease mechanisms is excitotoxicity, in which excessive cytosolic calcium causes neuronal death. Although most calcium may originate from
Autor:
Wendy Scheveneels, Koen Poesen, Philip Van Damme, Wim Robberecht, Dora Kiraly, Elke Bogaert, Joke Dhondt, Nicole Hersmus, Ludo Van Den Bosch
Publikováno v:
Neurobiology of Aging. 31:2185-2191
Influx of Ca(2+) ions through the α-amino-3-hydroxy-5-methylisoxazole propionic acid (AMPA) receptors is toxic to neurons and contributes to motor neuron degeneration observed in amyotrophic lateral sclerosis (ALS). The Ca(2+) permeability of the AM