Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Wendy S. Hahn"'
Autor:
David A. Bernlohr, Wendy S. Hahn, Amy K. Hauck, Yue Chen, Raphael Petegrosso, Rui Kuang, Tong Zhou
In obesity-linked insulin resistance, oxidative stress in adipocytes leads to lipid peroxidation and subsequent carbonylation of proteins by diffusible lipid electrophiles. Reduction in oxidative stress attenuates protein carbonylation and insulin re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b512f179365992590180ad052daaed03
https://europepmc.org/articles/PMC6120186/
https://europepmc.org/articles/PMC6120186/
Autor:
Dalay H. Olson, Do Hyung Kim, Jovan Kuzmicic, David A. Bernlohr, Ji Man Park, Joel S. Burrill, Wendy S. Hahn
Publikováno v:
Biochemical and biophysical research communications. 493(3)
Mitochondrially-derived oxidative stress has been implicated in the development of obesity-induced insulin resistance and is correlated with down regulation of Peroxiredoxin-3 (Prdx3). Prdx3 knockout mice exhibit whole-body insulin resistance, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaca6a00f6f7618004c00ba287880a99
https://pubmed.ncbi.nlm.nih.gov/28986255
https://pubmed.ncbi.nlm.nih.gov/28986255
Publikováno v:
Diabetes
Obesity-induced insulin resistance has been linked to adipose tissue lipid aldehyde production and protein carbonylation. Trans-4-hydroxy-2-nonenal (4-HNE) is the most abundant lipid aldehyde in murine adipose tissue and is metabolized by glutathione
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36552ef4afdc108279e491f5e8368f7
http://europepmc.org/articles/PMC3868039
http://europepmc.org/articles/PMC3868039
Autor:
Margaret A. Donoghue, David A. Bernlohr, Eric K. Long, Sergio Lavandero, Timothy J. Griffin, Edgar A. Arriaga, Jessica Curtis, Wendy S. Hahn, Aníbal G. Armién, Jacob J. Inda, Matthew D. Stone, David J. Droullard, Jovan Kuzmicic
Publikováno v:
Journal of Biological Chemistry. 287:32967-32980
Carbonylation is the covalent, non-reversible modification of the side chains of cysteine, histidine, and lysine residues by lipid peroxidation end products such as 4-hydroxy- and 4-oxononenal. In adipose tissue the effects of such modifications are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7abdce03f924280e1ac6ba6ffe8ea8
https://doi.org/10.1074/jbc.m112.400663
https://doi.org/10.1074/jbc.m112.400663
Autor:
Eric K. Long, Wendy S. Hahn, Edgar A. Arriaga, Jessica Curtis, David A. Bernlohr, Joel S. Burrill
Publikováno v:
Trends in Endocrinology & Metabolism. 23:399-406
Oxidative stress is linked to the production of reactive lipid aldehydes that non-enzymatically alkylate cysteine, histidine, or lysine residues in a reaction termed protein carbonylation. Reactive lipid aldehydes and their derivatives are detoxified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdd4a9f5f8d00d5f627ddf3c42335da
https://doi.org/10.1016/j.tem.2012.05.008
https://doi.org/10.1016/j.tem.2012.05.008
Autor:
David A. Bernlohr, Wendy S. Hahn, Jovan Kuzmicic, Edgar A. Arriaga, Rocio Foncea, Sergio Lavandero, Margaret A. Donoghue, Michael D. Jensen, Joel S. Burrill
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 306(9)
Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics. Macrophage infiltration of adipose tissue and the chronic low-grade production of inflammatory cytokines have been mechanistically l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f4c31189fa58cc17e09875cd42d4fd
https://pubmed.ncbi.nlm.nih.gov/24595304
https://pubmed.ncbi.nlm.nih.gov/24595304
Publikováno v:
Methods in enzymology. 538
Reactive oxygen species-mediated attack of the acyl chains of polyunsaturated fatty acids and triglycerides leads to the formation of lipid hydroperoxides. Lipid hydroperoxides are subject to nonenzymatic Fenton chemistry producing a variety of react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69d6cde84a25f493bf1f0d93ea05e09e
https://pubmed.ncbi.nlm.nih.gov/24529443
https://pubmed.ncbi.nlm.nih.gov/24529443
Reactive oxygen species-mediated attack of the acyl chains of polyunsaturated fatty acids and triglycerides leads to the formation of lipid hydroperoxides. Lipid hydroperoxides are subject to nonenzymatic Fenton chemistry producing a variety of react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e6fd0a4a51f68727317053540ffb7d7
https://doi.org/10.1016/b978-0-12-800280-3.00014-1
https://doi.org/10.1016/b978-0-12-800280-3.00014-1
Autor:
Wendy S. Hahn, Young Sung Yun, Kwan Hyun Kim, Young Mi Kim, Tae Youl Ha, Xin Xu, Seung Hyun Ro, Ji Man Park, Minchul Seo, David A. Bernlohr, Chang Hwa Jung, Edgar A. Arriaga, Do Hyung Kim
ULK1 (unc-51 like kinase 1) is a serine/threonine protein kinase that plays a key role in regulating the induction of autophagy. Recent studies using autophagy-defective mouse models, such as atg5- or atg7-deficient mice, revealed an important functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab3885439630f018fef54df9a06380e
https://europepmc.org/articles/PMC4028344/
https://europepmc.org/articles/PMC4028344/
Publikováno v:
The FASEB Journal. 26
To assess the effects of proinflammatory cytokines on mitochondrial function 3T3-L1 adipocytes were treated with TNFα, IL-6 or IL-1β (1 nM, 0–96 h) and evaluated for mitochondrial function as well ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::475d209c6f834d037644ed6c4cc203d7
https://doi.org/10.1096/fasebj.26.1_supplement.565.16
https://doi.org/10.1096/fasebj.26.1_supplement.565.16