Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Wendy R Gordon"'
Autor:
Bryan J Jones, Robert L Evans, Nathan J Mylrea, Debayan Chaudhury, Christine Luo, Bo Guan, Colin T Pierce, Wendy R Gordon, Carrie M Wilmot, Romas J Kazlauskas
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0235341 (2020)
Hydroxynitrile lyases (HNL's) belonging to the α/β-hydrolase-fold superfamily evolved from esterases approximately 100 million years ago. Reconstruction of an ancestral hydroxynitrile lyase in the α/β-hydrolase fold superfamily yielded a catalyti
Externí odkaz:
https://doaj.org/article/1032b638bceb4ed6a0096543bc797ca2
Publikováno v:
eLife, Vol 8 (2019)
Proteolysis of transmembrane receptors is a critical cellular communication mechanism dysregulated in disease, yet decoding proteolytic regulation mechanisms of hundreds of shed receptors is hindered by difficulties controlling stimuli and unknown fa
Externí odkaz:
https://doaj.org/article/1a053fc62c1e4fb0ada97f102b933f50
Autor:
Marcus D. Kelly, Matthew R. Pawlak, Kevin H. Zhan, Ghaidan A. Shamsan, Wendy R. Gordon, David J. Odde
Publikováno v:
APL Bioengineering, Vol 8, Iss 3, Pp 036102-036102-11 (2024)
Cell migration is the major driver of invasion and metastasis during cancer progression. For cells to migrate, they utilize the actin–myosin cytoskeleton and adhesion molecules, such as integrins and CD44, to generate traction forces in their envir
Externí odkaz:
https://doaj.org/article/1e07d54b25c34fafa4f2d643b0677027
Publikováno v:
Cell Reports: Methods, Vol 4, Iss 7, Pp 100821- (2024)
Molecular tension sensors are central tools for mechanobiology studies but have limitations in interpretation. Reporting in Cell Reports Methods, Shoyer et al. discover that fluorescent protein photoswitching in concert with sensor extension may expa
Externí odkaz:
https://doaj.org/article/399a3da0ab7640b9ae82ab393d52da58
Autor:
Miguel Aste-Amézaga, Ningyan Zhang, Janet E Lineberger, Beth A Arnold, Timothy J Toner, Mingcheng Gu, Lingyi Huang, Salvatore Vitelli, Kim T Vo, Peter Haytko, Jing Zhang Zhao, Frederic Baleydier, Sarah L'Heureux, Hongfang Wang, Wendy R Gordon, Elizabeth Thoryk, Marie Blanke Andrawes, Kittichoat Tiyanont, Kimberly Stegmaier, Giovanni Roti, Kenneth N Ross, Laura L Franlin, Hui Wang, Fubao Wang, Michael Chastain, Andrew J Bett, Laurent P Audoly, Jon C Aster, Stephen C Blacklow, Hans E Huber
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9094 (2010)
Notch receptors normally play a key role in guiding a variety of cell fate decisions during development and differentiation of metazoan organisms. On the other hand, dysregulation of Notch1 signaling is associated with many different types of cancer
Externí odkaz:
https://doaj.org/article/b4ac98e727c04ff3ad08212b68b47d08
Autor:
Wendy R Gordon, Didem Vardar-Ulu, Sarah L'Heureux, Todd Ashworth, Michael J Malecki, Cheryll Sanchez-Irizarry, Debbie G McArthur, Gavin Histen, Jennifer L Mitchell, Jon C Aster, Stephen C Blacklow
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6613 (2009)
Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the re
Externí odkaz:
https://doaj.org/article/bd8fa4227a984c5fb57219385262de3b
Autor:
Matthew R. Pawlak, Adam T. Smiley, Maria Paz Ramirez, Marcus D. Kelly, Ghaidan A. Shamsan, Sarah M. Anderson, Branden A. Smeester, David A. Largaespada, David J. Odde, Wendy R. Gordon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Mechanical forces drive critical cellular processes that are reflected in mechanical phenotypes, or mechanotypes, of cells and their microenvironment. We present here “Rupture And Deliver” Tension Gauge Tethers (RAD-TGTs) in which flow c
Externí odkaz:
https://doaj.org/article/1fd6216c1397488692642b2a66cb4e0c
Autor:
Adam T. Smiley, Kassidy J. Tompkins, Matthew R. Pawlak, August J. Krueger, Robert L. Evans, Ke Shi, Hideki Aihara, Wendy R. Gordon
Publikováno v:
mBio, Vol 14, Iss 1 (2023)
ABSTRACT Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication. These functions are mediated by covalent linkage of the Rep to its substrat
Externí odkaz:
https://doaj.org/article/098483ce13204a31825556df811ad888
Autor:
Adam T. Smiley, Kassidy J. Tompkins, Matthew R. Pawlak, August J. Krueger, Robert L. Evans, Ke Shi, Hideki Aihara, Wendy R. Gordon
Publikováno v:
mBio.
Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication. These functions are mediated by covalent linkage of the Rep to its substrate post cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03ccff2d0d956c4ad11ec4c7d45f8b9
https://pubmed.ncbi.nlm.nih.gov/36541758
https://pubmed.ncbi.nlm.nih.gov/36541758
Autor:
Matthew R. Pawlak, Adam T. Smiley, Marcus D. Kelly, Ghaidan A. Shamsan, Sarah M. Anderson, Branden A. Smeester, David A. Largaespada, David J. Odde, Wendy R. Gordon
Mechanical force is a key driver of cellular processes and is dysregulated in many diseases. Measuring cellular tensions to elucidate mechanotransduction pathways typically involves high-resolution but low throughput imaging of surfaces and arduous e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46cbef743bf47cb12a9a4d77309c293d
https://doi.org/10.1101/2022.11.08.515662
https://doi.org/10.1101/2022.11.08.515662
