Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wendy P. Loomis"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Inflammasome formation, arising from pathogen or internal activating signals, is a key step in canonical pyroptosis, a gasdermin-mediated inflammatory cell death. Inhibition of pyroptosis has great clinical relevance due to its involvement i
Externí odkaz:
https://doaj.org/article/45897d4029054de78e5c02e596a80fce
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract Pyroptosis is a cell death process that causes inflammation and contributes to numerous diseases. Pyroptosis is mediated by caspase-1 family proteases that cleave the pore-forming protein gasdermin D, causing plasma membrane rupture and rele
Externí odkaz:
https://doaj.org/article/0daf9f697c8d412588cd9d243688b7ad
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f55264ea4ec34321bd1c19df12d9b0cb
Autor:
Wendy P. Loomis, Tessa Bergsbaken
Publikováno v:
Methods in Molecular Biology ISBN: 9781071630396
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::177dfa486ed60703b8e468a90d6e8ce4
https://doi.org/10.1007/978-1-0716-3040-2_14
https://doi.org/10.1007/978-1-0716-3040-2_14
Publikováno v:
Cell Death and Disease, Vol 10, Iss 4, Pp 1-10 (2019)
Cell Death & Disease
Cell Death & Disease
Pyroptosis is a programmed process of proinflammatory cell death mediated by caspase-1-related proteases that cleave the pore-forming protein, gasdermin D, causing cell lysis and release of inflammatory intracellular contents. The amino acid glycine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac3cf2858bdd491da510c486482fd2a
http://link.springer.com/article/10.1038/s41419-019-1559-4
http://link.springer.com/article/10.1038/s41419-019-1559-4
Autor:
Wendy P Loomis, Matthew L Johnson, Alicia Brasfield, Marie-Pierre Blanc, Jaehun Yi, Samuel I Miller, Brad T Cookson, Adeline M Hajjar
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111763 (2014)
The lysosomal membrane transporter, Nramp1, plays a key role in innate immunity and resistance to infection with intracellular pathogens such as non-typhoidal Salmonella (NTS). NTS-susceptible C57BL/6 (B6) mice, which express the mutant Nramp1D169 al
Externí odkaz:
https://doaj.org/article/171d616242474a60bb98e4d4e107a71a
Publikováno v:
Infect Immun
Immunocompromised patients are more susceptible to recurrent nontyphoidal Salmonella (NTS) bacteremia. A key manifestation of HIV infection is the loss of CD4 T cells, which are crucial for immunity to Salmonella infection. We characterized the conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fcfa60e96962ebe101aacc05813942b
https://pubmed.ncbi.nlm.nih.gov/33046510
https://pubmed.ncbi.nlm.nih.gov/33046510
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9, p e1000573 (2009)
All Yersinia species target and bind to phagocytic cells, but uptake and destruction of bacteria are prevented by injection of anti-phagocytic Yop proteins into the host cell. Here we provide evidence that CD8(+) T cells, which canonically eliminate
Externí odkaz:
https://doaj.org/article/b3b7cce9a45946b2a946b54a0d9e518d
Autor:
Wendy P. Loomis, Benjamin Kehimkar, Kristian E. Swearingen, Norman J. Dovichi, Brad T. Cookson
Publikováno v:
Talanta. 81:948-953
A common method for quantifying cell death is measuring the concentration of lactate dehydrogenase (LDH) released by cells as their membranes become unstable. In cells expressing green fluorescent protein (GFP), degradation of the cell membrane also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a635e314cf6b6796cd1c61e91bbd45f
https://doi.org/10.1016/j.talanta.2010.01.041
https://doi.org/10.1016/j.talanta.2010.01.041
Autor:
David Regan, Pam Ovendale, Steven P. Fling, Wendy P. Loomis, Michael N. Starnbach, Bruce Hess, Mark R. Alderson
Publikováno v:
The Journal of Immunology. 171:4742-4749
During its developmental cycle, the intracellular bacterial pathogen Chlamydia trachomatis remains confined within a protective vacuole known as an inclusion. Nevertheless, CD8+ T cells that recognize Chlamydia Ags in the context of MHC class I molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d64316534573ef1c543096f1cf1c69
https://doi.org/10.4049/jimmunol.171.9.4742
https://doi.org/10.4049/jimmunol.171.9.4742