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Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways

Autor: Ian R. Kill, Wendy Ofosu, Joanna M. Bridger, Craig S. Clements, Evgeny M. Makarov, David Tree, Christopher H. Eskiw, Mehmet U. Bikkul

Publikováno v: Biogerontology

Hutchinson–Gilford progeria syndrome (HGPS) is a rare, premature ageing syndrome in children. HGPS is normally caused by a mutation in the LMNA gene, encoding nuclear lamin A. The classical mutation in HGPS leads to the production of a toxic trunca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f6b2fd09330521c2ec71ca71051a6af
http://europepmc.org/articles/PMC6535420

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