Ursodeoxycholic Acid Versus Placebo in Women With Intrahepatic Cholestasis of Pregnancy (PITCHES): A Randomized Controlled Trial

Autor: Karen Lincoln, Malcolm MacDougall, Franz Majoko, Louise Linsell, Jane E. Preston, Anna Haestier, Muna Noori, Bee K. Tan, Ellen Knox, Amarnath Bhide, Jenny Chambers, Madhuchanda Dey, Mumtaz Rashid, Catherine Williamson, Rahila Khan, Radha Indusekhar, Edmund Juszczak, Rachael Hunter, Rita Arya, Irshad Ahmed, Jennifer L Bell, Anne Smith, Heather Brown, Catharina Schram, Leila Fahel, Jon Dorling, Karen McIntyre, Ruta Gada, George Bugg, Joanna Girling, Alison Kirkpatrick, Peter H. Dixon, Nishigandh Deole, Wendy Oakley, Poornima Ranka, Manjula Samyraju, Lucy C Chappell, B. Jones, S Stone, Virginia Beckett, Helen Cameron, Sean Hughes, Seema Sen, Jim G Thornton, Marwan Salloum, James Dwyer

Publikováno v: Lancet (London, England)
Chappell, L C, Bell, J L, Smith, A, Linsell, L, Juszczak, E, Dixon, P H, Chambers, J, Hunter, R, Dorling, J & Williamson, C & Thornton, J G 2019, ' Ursodeoxycholic acid versus placebo in women with intrahepatic cholestasis of pregnancy (PITCHES) : a randomised controlled trial ', The Lancet, vol. 394, no. 10201, pp. 849-860 . https://doi.org/10.1016/S0140-6736(19)31270-X

BACKGROUND: Intrahepatic cholestasis of pregnancy, characterised by maternal pruritus and increased serum bile acid concentrations, is associated with increased rates of stillbirth, preterm birth, and neonatal unit admission. Ursodeoxycholic acid is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0adec18454615bb09f4e6e69942d8f2
https://doi.org/10.1097/01.ogx.0000654104.20923.e4