Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Wendy O. Adamowicz"'
Autor:
Robin J. Kleiman, Alexander J. Hartman, Alison Romegialli, Abigail Mariga, Veronica Reinhart, Michy P. Kelly, Geetanjali Pathak, Susan E. Bove, Wendy O. Adamowicz
Publikováno v:
Cellular Signalling. 26:383-397
3',5'-cyclic nucleotide phosphodiesterases (PDEs) are the only known enzymes to compartmentalize cAMP and cGMP, yet little is known about how PDEs are dynamically regulated across the lifespan. We mapped mRNA expression of all 21 PDE isoforms in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a965e2641b05e6676e6d0909585ea2
https://doi.org/10.1016/j.cellsig.2013.10.007
https://doi.org/10.1016/j.cellsig.2013.10.007
Autor:
Gregory W Cadelina, Catherine D Pilsmaker, Sharon Carmel, Robin J. Kleiman, Jo Ann Dumin, Abigail Mariga, Wendy O. Adamowicz, Elena M. Drummond, Thomas A. Lanz, Brentt J Swetter, Susan E. Bove
Publikováno v:
Biomarkers. 17:524-531
Adult rats were treated acutely with peripheral kainic acid (KA), and changes in brain-derived neurotrophic factor (BDNF) mRNA and protein were tracked over time across multiple brain regions. Despite robust elevation in both mRNA and protein in mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a8776a0782dde56fce76b4b674adeb
https://doi.org/10.3109/1354750x.2012.694476
https://doi.org/10.3109/1354750x.2012.694476
Autor:
William D. Eldred, Daniel Morton, Frank S. Menniti, A.B. Jakowski, Z. Xie, Wendy O. Adamowicz, Diane Stephenson, Robin J. Kleiman, Christine A. Strick, Robert D. Williams
Publikováno v:
Neuroscience. 139:597-607
PDE10A is a recently identified phosphodiesterase that is highly expressed by the GABAergic medium spiny projection neurons of the mammalian striatum. Inhibition of PDE10A results in striatal activation and behavioral suppression, suggesting that PDE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3785ba43da2d6aa603e90f7f9d4e15af
https://doi.org/10.1016/j.neuroscience.2005.12.042
https://doi.org/10.1016/j.neuroscience.2005.12.042
Autor:
Tim M. Coskran, Robin J. Kleiman, Margaret B. Wilhelms, Daniel Morton, Michele M. O'Donnell, Wendy O. Adamowicz, Kathleen B. Muravnick, Frank S. Menniti, Diane Stephenson
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 57(10)
Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. PDE2A is an evolutionarily conserved cGMP-stimulated cAMP and cGMP PDE. In the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e580f08ac27738a12fe0e00fa0d462d3
https://pubmed.ncbi.nlm.nih.gov/19506089
https://pubmed.ncbi.nlm.nih.gov/19506089
Autor:
Frederick R. Nelson, Jessica Adams, Robin J. Kleiman, Kristin St. Germain, Eric Schaeffer, Lori L. Badura, Katherine Fisher, Linda Reynolds, Jeffrey Sprouse, Janice Holland, Wendy O. Adamowicz, Julie Cianfrogna, Terri A. Swanson, Barbara Tate
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 322(2)
Casein kinase Iepsilon (CKIepsilon) is an essential component of the biological clock, phosphorylating PER proteins, and in doing so regulating their turnover and nuclear entry in oscillator cells of the suprachiasmatic nucleus (SCN). Although heredi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c225b60638396901db1f7a859b18d7
https://pubmed.ncbi.nlm.nih.gov/17502429
https://pubmed.ncbi.nlm.nih.gov/17502429
Autor:
Timothy M. Coskran, Daniel Morton, Frank S. Menniti, Wendy O. Adamowicz, Robin J. Kleiman, Anne M. Ryan, Christine A. Strick, Christopher J. Schmidt, Diane T. Stephenson
Publikováno v:
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 54(11)
A monoclonal antibody directed against the amino terminal of rat phosphodiesterase 10A (PDE10A) was used to localize PDE10A in multiple central nervous system (CNS) and peripheral tissues from mouse, rat, dog, cynomolgus macaque, and human. PDE10A im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa459994978860bebce540e70adc1b55
https://pubmed.ncbi.nlm.nih.gov/16864896
https://pubmed.ncbi.nlm.nih.gov/16864896