Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Wendy Noble"'
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/2b288fcdbef24653b6354a24b830f7bc
Autor:
Andrea Markovinovic, Sandra M. Martín-Guerrero, Gábor M. Mórotz, Shaakir Salam, Patricia Gomez-Suaga, Sebastien Paillusson, Jenny Greig, Younbok Lee, Jacqueline C. Mitchell, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) accumulations are hallmark pathologies of FTD/ALS and mutations in the
Externí odkaz:
https://doaj.org/article/959726ed7de941829423f9bf27ab624c
Autor:
Beatriz G. Perez-Nievas, Louisa Johnson, Paula Beltran-Lobo, Martina M. Hughes, Luciana Gammallieri, Francesca Tarsitano, Monika A. Myszczynska, Irina Vazquez-Villasenor, Maria Jimenez-Sanchez, Claire Troakes, Stephen B. Wharton, Laura Ferraiuolo, Wendy Noble
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Pathological interactions between β-amyloid (Aβ) and tau drive synapse loss and cognitive decline in Alzheimer’s disease (AD). Reactive astrocytes, displaying altered functions, are also a prominent feature of AD brain. This l
Externí odkaz:
https://doaj.org/article/d262341bcc2d4dd5ae59b2b8156cdf4d
Autor:
Naomi Hartopp, Dawn H W. Lau, Sandra M. Martin-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Jenny Greig, Elizabeth B. Glennon, Claire Troakes, Patricia Gomez-Suaga, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many neuronal functions that are perturbed in amyotrophic lateral sclerosis (ALS) and perturbation to ER-mitochondria signaling is seen in cell and transgenic models of ALS.
Externí odkaz:
https://doaj.org/article/ab769bb8dd764b90914229b46ae9481b
Autor:
Gábor M. Mórotz, Sandra M. Martín-Guerrero, Andrea Markovinovic, Sebastien Paillusson, Matthew R. G. Russell, Pedro M. Pereira Machado, Roland A. Fleck, Wendy Noble, Christopher C.J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of fundamental physiological processes. This signaling involves close physical contacts between the two organelles that are mediated by the VAPB-PTPIP51 ″tethering
Externí odkaz:
https://doaj.org/article/39eaf584213b4fd8b1fbbb27b0353415
Autor:
Sandra M. Martín-Guerrero, Andrea Markovinovic, Gábor M. Mórotz, Shaakir Salam, Wendy Noble, Christopher C. J. Miller
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two major neurodegenerative diseases. FTD is the second most common cause of dementia and ALS is the most common form of motor neuron disease. These diseases are now known to b
Externí odkaz:
https://doaj.org/article/53cde5ce80ed4175ad8c5d948bb33cbb
Autor:
Gábor M. Mórotz, Elizabeth B. Glennon, Jenny Greig, Dawn H. W. Lau, Nishita Bhembre, Francesca Mattedi, Nadine Muschalik, Wendy Noble, Alessio Vagnoni, Christopher C. J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP. Moreover, alter
Externí odkaz:
https://doaj.org/article/98c195ce202446dca910c86e79b79ccb
Autor:
Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble, Christopher C. J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-16 (2019)
Abstract Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for
Externí odkaz:
https://doaj.org/article/c1a67a677a2d464dac0f9c9c50fcb0e5
Autor:
Patricia Gómez-Suaga, Beatriz G. Pérez-Nievas, Elizabeth B. Glennon, Dawn H. W. Lau, Sebastien Paillusson, Gábor M. Mórotz, Tito Calì, Paola Pizzo, Wendy Noble, Christopher C. J. Miller
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Signaling between the endoplasmic reticulum (ER) and mitochondria regulates a number of key neuronal functions. This signaling involves close physical contacts between the two organelles that are mediated by “tethering proteins” that fun
Externí odkaz:
https://doaj.org/article/6628b43484524081899c86868433aa9c
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)
Abstract Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pa
Externí odkaz:
https://doaj.org/article/4ad5ef18337243a28630ef613a282fa8