Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Wendy M Swetzig"'
Autor:
Song Liu, Sangeeta Kumari, Qiang Hu, Dhirodatta Senapati, Varadha Balaji Venkadakrishnan, Dan Wang, Adam D DePriest, Simon E Schlanger, Salma Ben-Salem, Malyn May Valenzuela, Belinda Willard, Shaila Mudambi, Wendy M Swetzig, Gokul M Das, Mojgan Shourideh, Shahriah Koochekpour, Sara Moscovita Falzarano, Cristina Magi-Galluzzi, Neelu Yadav, Xiwei Chen, Changshi Lao, Jianmin Wang, Jean-Noel Billaud, Hannelore V Heemers
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/9aebacceecd24ba98796d96b142dcb42
Autor:
Song Liu, Sangeeta Kumari, Qiang Hu, Dhirodatta Senapati, Varadha Balaji Venkadakrishnan, Dan Wang, Adam D DePriest, Simon E Schlanger, Salma Ben-Salem, Malyn May Valenzuela, Belinda Willard, Shaila Mudambi, Wendy M Swetzig, Gokul M Das, Mojgan Shourideh, Shahriah Koochekpour, Sara Moscovita Falzarano, Cristina Magi-Galluzzi, Neelu Yadav, Xiwei Chen, Changshi Lao, Jianmin Wang, Jean-Noel Billaud, Hannelore V Heemers
Publikováno v:
eLife, Vol 6 (2017)
Standard treatment for metastatic prostate cancer (CaP) prevents ligand-activation of androgen receptor (AR). Despite initial remission, CaP progresses while relying on AR. AR transcriptional output controls CaP behavior and is an alternative therape
Externí odkaz:
https://doaj.org/article/41305a6fc01f416095798be8b5b7c5bf
Autor:
Chetan C. Oturkar, Spencer R. Rosario, Alan D. Hutson, Adrianne Groman, Stephen B. Edge, Carl D. Morrison, Wendy M. Swetzig, Jianmin Wang, Jun Hyoung Park, Benny Abraham Kaipparettu, Prashant K. Singh, Shicha Kumar, Helen H. Cappuccino, Manish Ranjan, Araba Adjei, Mohammad Ghasemi, Andrew K.L. Goey, Swati Kulkarni, Gokul M. Das
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109995- (2024)
Summary: The canonical mechanism behind tamoxifen’s therapeutic effect on estrogen receptor α/ESR1+ breast cancers is inhibition of ESR1-dependent estrogen signaling. Although ESR1+ tumors expressing wild-type p53 were reported to be more responsi
Externí odkaz:
https://doaj.org/article/04d36b95d2554e01bb9488680b2e7511
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29466 (2011)
Noxa is a Bcl-2-homology domain (BH3)-only protein reported to be a proapoptotic member of the Bcl-2 family. Estrogen has been well documented to stimulate cell growth and inhibit apoptosis in estrogen receptor (ER)-positive breast cancer cells. Intr
Externí odkaz:
https://doaj.org/article/ca1e99419e1546d7ad3a81569aa2b6e3
Autor:
Gokul M. Das, Swati A. Kulkarni, Chetan Oturkar, Spencer Rosario, Stephen B. Edge, Jianmin Wang, Wendy M. Swetzig, Alan D. Hutson, Benny Kaipparettu, Adrienne Groman, Araba Adjei, Andrew K. Goey, Carl D. Morrison, Shicha Kumar
Publikováno v:
Cancer Research. 83:PD10-05
Therapeutic effect of tamoxifen (Tam) against ER+ breast cancer (BC) is known to be mediated by its binding to estrogen receptor-alpha (ERά/ESR1) and inhibiting estrogen signaling leading to altered gene expression. Besides this canonical mode of fu
Autor:
Christina Adams, Creighton J Creighton, Chetan C. Oturkar, Benny Abraham Kaipparettu, Jun Hyoung Park, Nadi Wickramasekera, Sanjay Bansal, Wendy M. Swetzig, Laxmi Silwal-Pandit, Alka Mukhopadhyay, Santhi D. Konduri, Utpal K. Mukhopadhyay, Anne Lise Børresen-Dale, Alexander Caradori, Austin Miller, Gokul M. Das, Rajesh Medisetty
Publikováno v:
Cancer Research. 80:P3-10
Whether estrogen receptor beta (ERβ/ESR2) is a pro- or anti-oncogenic protein in breast cancer has been controversial. ERβ levels are generally high in triple-negative breast cancer (TNBC). Reports including the Cancer Genome Atlas (TCGA) show that
Autor:
Valery Adorno-Cruz, Mathew Cowan, John R. Lurain, Masha Kocherginsky, Wendy M. Swetzig, Kaitlyn O'Shea, Emily Berry, Shohreh Shahabi, Deanna Taiym, Daniela Matei, Mario Javier Pineda, Valerie Nelson, Nikki L. Neubauer
Publikováno v:
Gynecologic oncology. 163(1)
Objective Tivozanib is a potent selective pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor with a long half-life. This study assessed its activity in patients with recurrent, platinum-resistant ovarian, fallopian tube or prim
Autor:
Alka Mukhopadhyay, Wiam Bshara, Alexander Caradori, Sanjay Bansal, Jun Hyoung Park, Benny Abraham Kaipparettu, Christina Adams, Anne Lise Børresen-Dale, Austin Miller, Wendy M. Swetzig, Chad J. Creighton, Laxmi Silwal-Pandit, Gokul M. Das, Rajesh Medisetty, Santhi D. Konduri, Utpal K. Mukhopadhyay, Nadi Wickramasekera, Angela Omilian, Chetan C. Oturkar
Publikováno v:
JNCI Journal of the National Cancer Institute
BackgroundAnti-tumorigenic vs pro-tumorigenic roles of estrogen receptor-beta (ESR2) in breast cancer remain unsettled. We investigated the potential of TP53 status to be a determinant of the bi-faceted role of ESR2 and associated therapeutic implica
Autor:
Margaux J. Kanis, John J. Turek, Nkechiyere G. Nwani, David D. Nolte, Wendy M. Swetzig, Zhe Li, Ran An, Daniela Matei
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Development of an assay to predict response to chemotherapy has remained an elusive goal in cancer research. We report a phenotypic chemosensitivity assay for epithelial ovarian cancer based on Doppler spectroscopy of infrared light scattered from in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e2662b754dc91d265a6932d6041669
https://doi.org/10.1101/2020.09.14.296863
https://doi.org/10.1101/2020.09.14.296863
Autor:
Thomas D. Hurley, Daniela Matei, Emma L. Barber, Yinu Wang, Nkechiyere G. Nwani, Salvatore Condello, Wendy M. Swetzig
Publikováno v:
Cancers
Volume 11
Issue 4
Cancers, Vol 11, Iss 4, p 502 (2019)
Volume 11
Issue 4
Cancers, Vol 11, Iss 4, p 502 (2019)
A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in cancer recurrence. There is emerging interest in developing targeted therapeutics to eradicate CSCs. Aldehyde-dehydrogenase