Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Wendy L Imlach"'
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8698 (2010)
The heart generates and propagates action potentials through synchronized activation of ion channels allowing inward Na(+) and Ca(2+) and outward K(+) currents. There are a number of K(+) channel types expressed in the heart that play key roles in re
Externí odkaz:
https://doaj.org/article/344993dc319946beaa6da9cabcddeced
Autor:
Alan Hegron, Chloe J. Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Dane D. Jensen, Alex R. B. Thomsen, Brian L. Schmidt, Wendy L. Imlach, Peter Gmeiner, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc8246a969b2b8c49fad75dacbbedbf6
https://doi.org/10.1073/pnas.2220979120
https://doi.org/10.1073/pnas.2220979120
Autor:
Raquel Tonello, Wayne B. Anderson, Steve Davidson, Virginie Escriou, Lei Yang, Brian L. Schmidt, Wendy L. Imlach, Nigel W. Bunnett
Publikováno v:
Pain.
Chronic pain involves sensitization of nociceptors and synaptic transmission of painful signals in nociceptive circuits in the dorsal horn of the spinal cord. We investigated the contribution of clathrin-dependent endocytosis to sensitization of noci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf4f8d03d3712e0661a399e641103ee
https://pubmed.ncbi.nlm.nih.gov/36378744
https://pubmed.ncbi.nlm.nih.gov/36378744
Autor:
Pawan Bista, Wendy L. Imlach
Publikováno v:
Medicines, Vol 6, Iss 3, p 91 (2019)
Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation of the trigeminal nerve or its branches, with both peripheral and central nervous system dysfunction contributing to the disorder. Trigeminal pain conditions pre
Externí odkaz:
https://doaj.org/article/36e9a0eaeb7d4901a80b97e80e7186a7
Autor:
Matthew J. Sykes, Wendy L. Imlach, Orsolya Kékesi, Yan T. Wong, Fei Yue Zhao, David Spanswick
Publikováno v:
Neuropharmacology. 198
Excitatory and inhibitory neurotransmission within the spinal dorsal horn is tightly controlled to regulate transmission of nociceptive signals to the brain. One aspect of this control is modulation of neuronal activity through cholinergic signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5220aa2cc7b07b4915dcf5e7318a6a
https://pubmed.ncbi.nlm.nih.gov/34416268
https://pubmed.ncbi.nlm.nih.gov/34416268
Autor:
Lauren T. May, Rebecca F. Bhola, Ling Yeong Chia, Patrick M. Sexton, Apurba Bhattarai, Yinglong Miao, Celine Valant, Jinan Wang, Jens Carlsson, Christopher J Draper-Joyce, Kelly O’Sullivan, Hariprasad Venugopal, MacDonald J. Christie, Nicolas Panel, Alisa Glukhova, Denise Wootten, India Cowie-Kent, Anh Nguyen, David M. Thal, Paul J. White, Wendy L. Imlach, Arthur Christopoulos, Radostin Danev, Peter J. Scammells
Publikováno v:
Nature
The adenosine A1 receptor (A1R) is a promising therapeutic target for non-opioid analgesic agents to treat neuropathic pain1,2. However, development of analgesic orthosteric A1R agonists has failed because of a lack of sufficient on-target selectivit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2e53305074f1d9735eb53ee169d32f
https://pubmed.ncbi.nlm.nih.gov/34561672
https://pubmed.ncbi.nlm.nih.gov/34561672
Autor:
Tristan Rawling, MacDonald J. Christie, Wendy L. Imlach, Bryony L. Winters, Rebecca F. Bhola, Robert J. Vandenberg
Publikováno v:
British Journal of Pharmacology. 175:2337-2347
Background Inhibitory neurotransmission plays an important role in controlling excitability within nociceptive circuits of the spinal cord dorsal horn. Loss of inhibitory signalling is thought to contribute to the development of pathological pain. Pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fd5208a5586fa9ef434f68477660ef4
https://doi.org/10.1111/bph.14189
https://doi.org/10.1111/bph.14189
Autor:
Wendy L. Imlach
Publikováno v:
Pharmacological Research. 116:93-99
Inhibitory glycinergic neurotransmission in the spinal cord dorsal horn plays an important role in regulating nociceptive signalling by inhibiting neuronal excitation. Blocking glycinergic transmission in the dorsal horn causes normally innocuous sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f1d2de786eb8d3c48262c624a7b152
https://doi.org/10.1016/j.phrs.2016.12.019
https://doi.org/10.1016/j.phrs.2016.12.019
Autor:
Song Y. Khor, Matthew J. Sykes, Nigel W. Bunnett, Thomas P. Davis, Michael R. Whittaker, Wendy L. Imlach, Nicholas A. Veldhuis, Dane D. Jensen, Tina Marie Lieu, Brian L. Schmidt, Teresa Pelissier, Nghia P. Truong, Louis M. Layani, John F. Quinn, Chris Lumb, P.A. Shenoy, Nicole N. Scheff, Paulina D. Ramírez-García, Quynh N. Mai, Rocco Latorre, Cameron J. Nowell, Daniel P. Poole, Gregory D. Stewart, Luis Constandil, Jeffri S. Retamal
Publikováno v:
Nat Nanotechnol
Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f2498ad67b5820322d6fc1a65c6e37
https://europepmc.org/articles/PMC7765343/
https://europepmc.org/articles/PMC7765343/
Autor:
Wendy L. Imlach, Pawan Bista
Publikováno v:
Medicines, Vol 6, Iss 3, p 91 (2019)
Medicines
Medicines
Trigeminal neuropathic pain is a chronic pain condition caused by damage or inflammation of the trigeminal nerve or its branches, with both peripheral and central nervous system dysfunction contributing to the disorder. Trigeminal pain conditions pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c32983dbacc9dd4d99afb00738ddea
https://www.mdpi.com/2305-6320/6/3/91
https://www.mdpi.com/2305-6320/6/3/91