Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Wendy Klement"'
Autor:
Florian Pernin, Qiao-Ling Cui, Abdulshakour Mohammadnia, Milton G. F. Fernandes, Jeffery A. Hall, Myriam Srour, Roy W. R. Dudley, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Hannah E. Salapa, Michael C. Levin, G. R. Wayne Moore, Timothy E. Kennedy, Christine Vande Velde, Jack P. Antel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs stalled in translation and considered as participants of the cellular re
Externí odkaz:
https://doaj.org/article/7ecd4f332096485d86164c4aeb9e24fc
Autor:
Priya Jhelum, Stephanie Zandee, Fari Ryan, Juan G. Zarruk, Bernhard Michalke, Vivek Venkataramani, Laura Curran, Wendy Klement, Alexandre Prat, Samuel David
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-22 (2023)
Abstract Ferroptosis is a form of lipid peroxidation-mediated cell death and damage triggered by excess iron and insufficiency in the glutathione antioxidant pathway. Oxidative stress is thought to play a crucial role in progressive forms of multiple
Externí odkaz:
https://doaj.org/article/18aee7bd8ba0455cb2561b0275634eaa
Autor:
Milton Guilherme Forestieri Fernandes, Abdulshakour Mohammadnia, Florian Pernin, Laura Eleonora Schmitz-Gielsdorf, Caroline Hodgins, Qiao-Ling Cui, Moein Yaqubi, Manon Blain, Jeffery Hall, Roy Dudley, Myriam Srour, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Jo Anne Stratton, Moses Rodriguez, Tanja Kuhlmann, Wayne Moore, Timothy E. Kennedy, Jack P. Antel
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Oligodendrocyte (OL) injury and loss are central features of evolving lesions in multiple sclerosis. Potential causative mechanisms of OL loss include metabolic stress within the lesion microenvironment. Here we use the injury response of pr
Externí odkaz:
https://doaj.org/article/0b83309164e245e4aea64f44e59886dc
Autor:
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Véronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal
Publikováno v:
Cells, Vol 12, Iss 18, p 2218 (2023)
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common cause of chronic liver disease worldwide, affecting 70–90% of obese individuals. In humans, a lower NAFLD incidence is reported in pre-menopausal women, although the mechanisms affording
Externí odkaz:
https://doaj.org/article/723b4e568dd542d3a783abf73120936d
Autor:
Hélène Jamann, Qiao-Ling Cui, Haritha L. Desu, Florian Pernin, Olivier Tastet, Alexandre Halaweh, Negar Farzam-kia, Victoria Hannah Mamane, Oumarou Ouédraogo, Aurélie Cleret-Buhot, Audrey Daigneault, Renaud Balthazard, Wendy Klement, Florent Lemaître, Nathalie Arbour, Jack Antel, Jo Anne Stratton, Catherine Larochelle
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multiple sclerosis (MS) is characterized by the loss of myelin and of myelin-producing oligodendrocytes (OLs) in the central nervous system (CNS). Pro-inflammatory CD4+ Th17 cells are considered pathogenic in MS and are harmful to OLs. We investigate
Externí odkaz:
https://doaj.org/article/53dccdeea5ea49b3b922cab52828fef2
Autor:
Léonie Dopavogui, Arnaud Polizzi, Anne Fougerat, Pascal Gourbeyre, Chloé Terciolo, Wendy Klement, Philippe Pinton, Joëlle Laffite, Anne-Marie Cossalter, Jean-Denis Bailly, Olivier Puel, Yannick Lippi, Claire Naylies, Hervé Guillou, Isabelle P. Oswald, Nicolas Loiseau
Publikováno v:
Toxins, Vol 14, Iss 2, p 83 (2022)
Fumonisin B1 (FB1) is a widespread mycotoxin produced by fungal Fusarium species—mainly in maize, one of the plants most commonly used for food and feed. Pigs and horses are the animal species most susceptible to this mycotoxin. FB1 exposure can ca
Externí odkaz:
https://doaj.org/article/119df9d03b9f4fe9afab309c371994c9
Autor:
Wendy Klement, Rita Garbelli, Emma Zub, Laura Rossini, Laura Tassi, Benoit Girard, Marine Blaquiere, Federica Bertaso, Julie Perroy, Frederic de Bock, Nicola Marchi
Publikováno v:
Neurobiology of Disease, Vol 113, Iss , Pp 70-81 (2018)
Background: Cerebrovascular dysfunction and inflammation occur in epilepsy. Here we asked whether pericytes, a pivotal cellular component of brain capillaries, undergo pathological modifications during experimental epileptogenesis and in human epilep
Externí odkaz:
https://doaj.org/article/108d8de664b84988b6ca28d0326f34bc
Autor:
Marc Charabati, Stephanie Zandee, Antoine P Fournier, Olivier Tastet, Karine Thai, Roxaneh Zaminpeyma, Marc-André Lécuyer, Lyne Bourbonnière, Sandra Larouche, Wendy Klement, Camille Grasmuck, Fiona Tea, Bettina Zierfuss, Ali Filali-Mouhim, Robert Moumdjian, Alain Bouthillier, Romain Cayrol, Evelyn Peelen, Nathalie Arbour, Catherine Larochelle, Alexandre Prat
Publikováno v:
Brain. 146:1483-1495
The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium represents one of the main CNS borders to interact with the infil
Autor:
Léonie Dopavogui, Marion Régnier, Arnaud Polizzi, Quentin Ponchon, Sarra Smati, Wendy Klement, Frédéric Lasserre, Céline Lukowicz, Yannick Lippi, Anne Fougerat, Justine Bertrand-Michel, Claire Naylies, Cécile Canlet, Laurent Debrauwer, Elodie Rousseau-Bacquié, Laurence Gamet-Payrastre, Charlène Dauriat, Josefina Casas, Siska Croubels, Siegrid De Baere, Hester M. Burger, Benoit Chassaing, Sandrine Ellero-Simatos, Hervé Guillou, Isabelle P. Oswald, Nicolas Loiseau
Publikováno v:
SCIENCE OF THE TOTAL ENVIRONMENT
Obesity, which is a worldwide public health issue, is associated with chronic inflammation that contribute to long-term complications, including insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease. We hypothesized that obesity m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c03b554fe9c2f2247ba3ce3683e4fd
https://biblio.ugent.be/publication/01H1NZVCZSTKN8D5FVNCGFA2WD/file/01H1P01NQH7G02S073WHQ5533W
https://biblio.ugent.be/publication/01H1NZVCZSTKN8D5FVNCGFA2WD/file/01H1P01NQH7G02S073WHQ5533W
Autor:
Negar Farzam‐kia, Florent Lemaître, Ana Carmena Moratalla, Yves Carpentier Solorio, Sandra Da Cal, Hélène Jamann, Wendy Klement, Jack Antel, Pierre Duquette, Jean Marc Girard, Alexandre Prat, Catherine Larochelle, Nathalie Arbour
Publikováno v:
Immunology and cell biologyREFERENCES. 101(1)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been implicated in numerous chronic inflammatory diseases, including multiple sclerosis (MS). GM-CSF impacts multiple properties and functions of myeloid cells via species-specific mechani