Výsledky vyhledávání - "Wendy Kennette"

Akademický článek

Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number.

Autor: Joseph Andrews, Wendy Kennette, Jenna Pilon, Alexandra Hodgson, Alan B Tuck, Ann F Chambers, David I Rodenhiser

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8665 (2010)

BackgroundWe have previously identified genome-wide DNA methylation changes in a cell line model of breast cancer metastasis. These complex epigenetic changes that we observed, along with concurrent karyotype analyses, have led us to hypothesize that

Externí odkaz: https://doaj.org/article/083ed21a7a92410faf37d5733e161a66

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Nuclear localization of maspin is essential for its inhibition of tumor growth and metastasis

Autor: Ann F. Chambers, Alan B. Tuck, John D. Lewis, Carl O. Postenka, Joe S. Mymryk, Vincent Giguère, Wendy Kennette, M. Nicole Hague, Brigitte Goulet, Amber Ablack

Publikováno v: ResearcherID

Maspin (mammary serine protease inhibitor or SerpinB5) acts as a tumor suppressor when overexpressed in aggressive cancer cell lines. However, its role in human cancer is controversial. Maspin expression has been associated with a poor prognosis in s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd64c798c9a461eb0ef722adf9f11980
https://doi.org/10.1038/labinvest.2011.66

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Metallothionein Mediates the Level and Activity of Nuclear Factor ΚB in Murine Fibroblasts

Autor: Wendy Kennette, Rudolfs K. Zalups, James Koropatnick, Heather L. Butcher, Olga Collins

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 310:589-598

The zinc-binding protein metallothionein (MT) is associated with resistance to apoptosis. We examined whether MT regulates the zinc-dependent antiapoptotic transcription factor nuclear factor KappaB (NF-KappaB), which is up-regulated under many condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993e626497d85a5a9d2f1faca8e7f38a
https://doi.org/10.1124/jpet.104.066126

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A sensitive time-resolved fluorescent immunoassay for metallothionein protein

Autor: Janice M. DeMoor, Olga Collins, James Koropatnick, Heather L. Butcher, Wendy Kennette

Publikováno v: Journal of Immunological Methods. 272:247-256

Metallothioneins (MTs) are a family of low molecular weight metal-binding proteins induced by a broad range of stress conditions, including exposure to transition metal ions. Biochemical and immunological methods to measure MT protein levels in tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66e0ad028697d229c1e8deab94b29d6
https://doi.org/10.1016/s0022-1759(02)00441-6

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Lymphatic metastasis of breast cancer cells is associated with differential gene expression profiles that predict cancer stem cell-like properties and the ability to survive, establish and grow in a foreign environment

Autor: Terlika S, Pandit, Wendy, Kennette, Lisa, Mackenzie, Guihua, Zhang, Waleed, Al-Katib, Joseph, Andrews, Sharon A, Vantyghem, D George, Ormond, Alison L, Allan, David I, Rodenhiser, Ann F, Chambers, Alan B, Tuck

Publikováno v: International journal of oncology. 35(2)

Although lymphatic dissemination is a major route for breast cancer metastasis, there has been little work to determine what factors control the ability of tumor cells to survive, establish and show progressive growth in a lymph node environment. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bba3a43dc7658335883ed6cdbdc524a
https://pubmed.ncbi.nlm.nih.gov/19578743

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Autor: D. George Ormond, Wendy Kennette, Joseph Andrews, David I. Rodenhiser, Alison L. Allan, Lisa Mackenzie, Ann F. Chambers, Alan B. Tuck, Waleed Al-Katib, Guihua Zhang, Terlika S. Pandit, Sharon A. Vantyghem

Publikováno v: Oncology Publications

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a435329c96bb60279cdf65c0aaca51
https://doi.org/10.3892/ijo_00000340

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Basal and zinc-induced metallothionein in resistance to cadmium, cisplatin, zinc, and tertbutyl hydroperoxide: studies using MT knockout and antisense-downregulated MT in mammalian cells

Autor: James Koropatnick, Rudolfs K. Zalups, Wendy Kennette, Olga Collins

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 88(2)

Metallothioneins (MTs) mediate resistance to metal and non-metal toxicants. To differentiate the role of MTs from other protective factors, resistance to zinc (Zn), cadmium (Cd), tertbutyl hydroperoxide (tBH), and cisplatin (CDDP) was compared in ren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e95830a566d5b776a6815fa7dad8fa8
https://pubmed.ncbi.nlm.nih.gov/16150881

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Subcellular targeting of human interleukin-10 in plants

Autor: Rima Menassa, R. T. Rymerson, Wendy Kennette, A. M. Jevnikar, Vi Nguyen, Jim Brandle

Publikováno v: Journal of biotechnology. 108(2)

The utility of plants for the production of a wide range of recombinant proteins is now clearly established. However, the challenge remains to produce these proteins at sufficient concentrations for extraction to be economically feasible. In this pap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91be2b466640be341322972706c7ba21
https://pubmed.ncbi.nlm.nih.gov/15129727

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Zinc-metallothionein levels are correlated with enhanced glucocorticoid responsiveness in mouse cells exposed to ZnCl(2), HgCl(2), and heat shock

Autor: Wendy Kennette, Olga Collins, James Koropatnick, Janice M. DeMoor

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 64(1)

Metallothioneins (MTs) are the major low molecular weight, zinc-binding proteins in mammalian cells. It has been hypothesized that they play a role in the function of zinc-dependent signal transduction proteins and transcription factors. We investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b813283284401bcc4eb44d57119c6ab4
https://pubmed.ncbi.nlm.nih.gov/11606802

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