Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Wendy Karen Alderton"'
Autor:
James Michael Woolven, Simon Teanby Hodgson, Miriam Crowe, Linda J. Russell, Wendy Karen Alderton, John Dawson, C. Lynn Chambers, Christopher Charles Frederick Hamlett, Richard G. Knowles, Richard Stocker, Robert J. Young, Paul John Beswick, David W. Brown, Anthony D R Angell, Savvas Kleanthous
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3037-3040
Heteroalicyclic carboxamidines were synthesised and evaluated as inhibitors of nitric oxide synthases. (2R)-2-Pyrrolidinecarboxamidine, in particular, was shown to be a highly potent in vitro (IC50 = 0.12 μM) and selective iNOS inhibitor (>100-fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773439dbec64b955efa494d151e9cf88
https://doi.org/10.1016/j.bmcl.2011.03.038
https://doi.org/10.1016/j.bmcl.2011.03.038
Autor:
Neil Waslidge, John Dawson, Rachel J. Russell, Caroline Craig, Edward P. Garvey, Salvador Moncada, Linda J. Russell, Richard G. Knowles, Daryl D. Rees, Jayne Monkhouse, Sheila Schwartz, Wendy Karen Alderton, Anthony D R Angell
Publikováno v:
British Journal of Pharmacology. 145:301-312
1 GW274150 ([2-[(1-iminoethyl) amino]ethyl]-L-homocysteine) and GW273629 (3-[[2-[(1-iminoethyl)amino]ethyl]sulphonyl]-L-alanine) are potent, time-dependent, highly selective inhibitors of human inducible nitric oxide synthase (iNOS) vs endothelial NO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8baa7563a07df8763a9177ae9eb4bac6
https://doi.org/10.1038/sj.bjp.0706168
https://doi.org/10.1038/sj.bjp.0706168
Publikováno v:
Trends in Pharmacological Sciences. 18:100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98f6636266334d91bf10cc640ab6b97c
https://doi.org/10.1016/s0165-6147(97)84479-3
https://doi.org/10.1016/s0165-6147(97)84479-3