Výsledky vyhledávání - "Wendy K. Alderton"

Akademický článek

Zebrafish: An in vivo model for the study of neurological diseases

Autor: J D Best, Wendy K Alderton

Publikováno v: Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 3, Pp 567-576 (2008)

J D Best, Wendy K AldertonSummit (Cambridge) Ltd., Beach Drive, Cambridge, UKAbstract: As the population ages, there is a growing need for effective therapies for the treatment of neurological diseases. A limited number of therapeutics are currently

Externí odkaz: https://doaj.org/article/c8ffa0def81f44648c917d916be30c05

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The 14q32 maternally imprinted locus is a major source of longitudinally stable circulating microRNAs as measured by small RNA sequencing

Autor: Wendy K. Alderton, J.C. Barnes, Usha Menon, Hector C. Keun, Ian Jacobs, Lauren Harper, Sophia Apostolidou, Gabriel N. Valbuena, Rhiannon Roberts

Publikováno v: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Understanding the normal temporal variation of serum molecules is a critical factor for identifying useful candidate biomarkers for the diagnosis and prognosis of chronic disease. Using small RNA sequencing in a longitudinal study of 66 women with no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660a1706e5a8213f96e7c3e9171552ed
https://pubmed.ncbi.nlm.nih.gov/31673048

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The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer

Publikováno v: Journal of Medicinal Chemistry. 51:5522-5532

Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation of the PI3K/ Akt signaling pathway in a wide variety of tumors. A series of thieno[3,2-d]pyrimidine derivatives were prepared and evaluated as inhibitors of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de0e3ae091925e99a0f90135c014d5f
https://doi.org/10.1021/jm800295d

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Zebrafish: An in vivo model for the study of neurological diseases

Autor: Wendy K Alderton, J D Best

Publikováno v: Neuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 3, Pp 567-576 (2008)
Neuropsychiatric Disease and Treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056c5328069c803a894a1221687924f4
http://www.dovepress.com/zebrafish-an-in-vivo-model-for-the-study-of-neurological-diseases-a1867

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Kinetics of CO binding to the haem domain of murine inducible nitric oxide synthase: differential effects of haem domain ligands

Autor: Thirza H. STEVENSON, Aldo F. GUTIERREZ, Wendy K. ALDERTON, Lu-yun LIAN, Nigel S. SCRUTTON

Publikováno v: Biochemical Journal. 358:201-208

The binding of CO to the murine inducible nitric oxide synthase (iNOS) oxygenase domain has been studied by laser flash photolysis. The effect of the (6R)-5,6,7,8-tetrahydro-l-biopterin (BH4) cofactor l-arginine and several Type I l-arginine analogue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96f97b2db9f59f05593d3408ae49d20f
https://doi.org/10.1042/bj3580201

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Nitric oxide synthases: structure, function and inhibition

Autor: Wendy K. ALDERTON, Chris E. COOPER, Richard G. KNOWLES

Publikováno v: Biochemical Journal. 357:593-615

This review concentrates on advances in nitric oxide synthase (NOS) structure, function and inhibition made in the last seven years, during which time substantial advances have been made in our understanding of this enzyme family. There is now inform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b53d67c927a06dae34eb612e370f631
https://doi.org/10.1042/bj3570593

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Nitroarginine and tetrahydrobiopterin binding to the haem domain of neuronal nitric oxide synthase using a scintillation proximity assay

Autor: Peter N. Lowe, Angela Boyhan, Wendy K. Alderton

Publikováno v: Biochemical Journal. 332:195-201

Nitric oxide synthases (NOS) have a bidomain structure comprised of an N-terminal oxygenase domain and a C-terminal reductase domain. The oxygenase domain binds haem, (6R)-5,6,7,8-tetrahydro-l-biopterin (tetrahydrobiopterin) and arginine, is the site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46170fb5961161bcdf304ff42c62888a
https://doi.org/10.1042/bj3320195

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Affinity Labeling of Recombinant Ricin A Chain with Procion Blue MX-R

Autor: Christopher R. Lowe, Wendy K. Alderton, David R. Thatcher

Publikováno v: European Journal of Biochemistry. 233:880-885

Recombinant ricin A chain was irreversibly modified by Procion blue MX-R, a dichlorotriazinyl analogue of Cibacron blue F3G-A, at pH 7.5 and 4 degrees C in 90 h with over 95% loss of activity in an in vitro translation assay. The presence of total ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b1d2b1f090cba2b450887692a4de7e5
https://doi.org/10.1111/j.1432-1033.1995.880_3.x

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Purification of recombinant ricin A chain with immobilised triazine dyes

Autor: Wendy K. Alderton, Christopher R. Lowe, David R. Thatcher

Publikováno v: Journal of Chromatography A. 677:289-299

Immunotoxins, such as those based on ricin A chain, must be rigorously purified before they can be administered in vivo. The work described in this paper investigates the interaction between recombinant ricin A chain and several triazine dyes and oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e53f9669805bc94cdec6e06d636801f
https://doi.org/10.1016/0021-9673(94)80157-6

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