Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Wendy J. Lawley"'
Autor:
Peter M. Brown, Andrew J. A. Charlton, Wendy J. Lawley, Elaine J. Hughson, Ainsley Jones, Helen H. Grundy
Publikováno v:
Journal of Agricultural and Food Chemistry. 54:1588-1593
This study describes a generic biological screening assay designed to detect anticoagulant rodenticides based on their inhibitory action on the vitamin K epoxide reductase protein complex, resulting in an accumulation of under-carboxylated prothrombi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1122b662ad23022e19c2fd38284e9c
https://doi.org/10.1021/jf052656n
https://doi.org/10.1021/jf052656n
Publikováno v:
Journal of Allergy and Clinical Immunology. 112:965-972
Background Human lung mast cells (HLMCs) and the human mast cell line HMC-1 express a strongly outwardly rectifying Cl − current characteristic of that carried by the voltage-dependent Cl − channel ClC-5. A similar but distinct current has been i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb441a94ec4e603d1c5f8bc75b2ef9a
https://doi.org/10.1016/j.jaci.2003.07.004
https://doi.org/10.1016/j.jaci.2003.07.004
Autor:
E. Holme, S. Fletcher, W.S. Hillis, K.L. Woods, Colin R. A. Hewitt, Iain B. Squire, Wendy J. Lawley
Publikováno v:
European Heart Journal. 20:1245-1252
Aims Administration of streptokinase results in an immunological response which may lead to increased risk of anaphylactic reaction or reduced thrombolytic efficacy on repeat administration. For these reasons current recommendations suggest that stre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a920cbec2c53f9a6241fd24913faf416
https://doi.org/10.1053/euhj.1999.1528
https://doi.org/10.1053/euhj.1999.1528
Publikováno v:
The FASEB Journal. 19:1006-1008
Human mast cells express the intermediate conductance Ca2+-activated K+ channel iKCa1, which opens following IgE-dependent activation. This results in cell membrane hyperpolarization and potentiation of both Ca2+ influx and degranulation. Mast cell a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed90903b005ed5890203b1e239d26aa
https://doi.org/10.1096/fj.04-3439fje
https://doi.org/10.1096/fj.04-3439fje
Autor:
Heather Hird, Sue McKenna, Beverley Hargadon, Philip Mallinder, Peter Bradding, A. W. A. Murray, Wendy J. Lawley
Publikováno v:
Mutation research. 572(1-2)
A well-characterised gain-of-function point mutation within exon 17 of the c-kit proto-oncogene known as Asp816Val is present in patients with mastocytosis. Activation of mast cells through this receptor primes them for IgE-dependent activation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3807ac47bb9e6d72a70b292303d5053
https://pubmed.ncbi.nlm.nih.gov/15790486
https://pubmed.ncbi.nlm.nih.gov/15790486
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 167(8)
The mechanism of mediator secretion from mast cells in disease is likely to include modulation of ion channel activity. Several distinct Ca2+, K+, and Cl− conductances have been identified in rodent mast cells, but there are no data on human mast c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16f1ee5a43e779f3195cc8757a66cd3
https://pubmed.ncbi.nlm.nih.gov/11591748
https://pubmed.ncbi.nlm.nih.gov/11591748
Publikováno v:
Clinical Science. 99:239
Streptokinase (SK) is a bacterial protein used clinically as a thrombolytic agent in humans. Administration of SK causes a rapid increase in the frequency of anti-SK T cells and the titre of specific anti-SK antibodies that, on subsequent administrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db25658403d6b7080f0c610cdecda99e
https://doi.org/10.1042/cs19990354
https://doi.org/10.1042/cs19990354