Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Wendy J. Freebern"'
Autor:
Mikhail M. Galperin, June L. Traicoff, Arun Ramesh, Wendy J. Freebern, Cynthia M. Haggerty, Dan-Paul Hartmann, Michael R. Emmert-Buck, Kevin Gardner, Vladimir Knezevic
Publikováno v:
BioTechniques, Vol 36, Iss 6, Pp 1046-1051 (2004)
The molecular profiles of protein expression from hundreds of cell lysates can be determined in a high-throughput manner by using fluorescent bead technologies, enzyme-linked immunosorbent assays (ELISAs), and protein microarrays. Although powerful,
Externí odkaz:
https://doaj.org/article/f544ab649e70497f898c7bf557949d73
Autor:
Celine Marban, José A. Lebrón, Anja Langenkamp, Stanley Parish, Jennifer Wheeler, Mark Collinge, Joseph Ghanime, Carolyne Dumont, Lisa Plitnick, Nianyu Li, Dingzhou Li, Patricia A. Schneider, Fanny Guimont-Derochers, Wendy J. Freebern
Publikováno v:
Journal of Immunotoxicology, Vol 17, Iss 1, Pp 51-58 (2020)
Nonclinical immunotoxicity evaluation is an important component of safety assessment for pharmaceuticals. One in vitro assay that can be applied in a weight of evidence assessment is the human lymphocyte activation (HuLA) assay, an antigen recall ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14cf53382b66451f0877b4a5f1e90381
https://doaj.org/article/d778ca1e897a4b63b8c879d6165eca51
https://doaj.org/article/d778ca1e897a4b63b8c879d6165eca51
Autor:
Andrea Kiessling, Frederic Brouta, Wendy J. Freebern, Marlowe J. Schneidkraut, Timothy K. MacLachlan, Birgit Fogal, Shawn Jay Berens, Sven Kronenberg, Curtis Maier, Laura Andrews, Cris Kamperschroer, Danuta J. Herzyk, Nikki Marshall
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 119
With the growth of monoclonal antibodies and other proteins as major modalities in the pharmaceutical industry, there has been an increase in pharmacology and toxicity testing of biotherapeutics in animals. Animals frequently mount an immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8126077e8f54fc5cf1ff6cfd870332
https://pubmed.ncbi.nlm.nih.gov/33220389
https://pubmed.ncbi.nlm.nih.gov/33220389
Autor:
Frank J. Simutis, Joshua T. Gamse, Michael J. Graziano, Helen G. Haggerty, Rashade Haynes, Wendy J. Freebern, Mary Pazian, James Crona, Roderick T. Bunch
Publikováno v:
Toxicology and applied pharmacology. 409
The OX40 receptor plays a crucial co-stimulatory role in T effector cell survival, expansion, cytokine production, and cytotoxicity to tumor cells; therefore, OX40 agonists are being evaluated as anti-cancer immunotherapies, especially in combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7115a3c8cf082be4d4cf00fc43ba2f0c
https://pubmed.ncbi.nlm.nih.gov/33069749
https://pubmed.ncbi.nlm.nih.gov/33069749
Autor:
Florence G. Burleson, Robert W. Luebke, Victor J. Johnson, Stefanie C.M. Burleson, Gary R. Burleson, Wendy J. Freebern
Publikováno v:
Methods in Molecular Biology ISBN: 9781493985487
The goal of immunotoxicity testing is to obtain data useful for immunotoxicity safety assessment. Guidance in the performance of immunotoxicity safety evaluations is provided in documents from the US EPA for chemicals and the ICH S8 document for phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cce4b2ab7186dc8240dfd3369c37ec04
https://doi.org/10.1007/978-1-4939-8549-4_9
https://doi.org/10.1007/978-1-4939-8549-4_9
Autor:
Jacintha Shenton, Mark Collinge, Joshua Arrington, Darrell R. Boverhof, Wendy J. Freebern, Herve Lebrec, Daniel T. Mytych, Brigitte Molinier, Lei Zhou, Kristin L. Henson, Ronald L. Wange, Marie Soleil Christin-Piché, Hans D. Ochs, Yung Yang
Publikováno v:
Regulatory Toxicology and Pharmacology. 69:7-21
The T-cell-dependent antibody response (TDAR) assay is a measure of immune function that is dependent upon the effectiveness of multiple immune processes, including antigen uptake and presentation, T cell help, B cell activation, and antibody product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7315045a36d2c566ee289463a46fa3ca
https://doi.org/10.1016/j.yrtph.2014.02.008
https://doi.org/10.1016/j.yrtph.2014.02.008
Autor:
Anthony M. Fletcher, John C. Kozlosky, Courtni Newsome, Jean G Sathish, Frank J. Simutis, Michael J. Graziano, Annette Capozzi, Daniel Szatkowski, Karen Price, John J. Engelhardt, Lila Ramaiah, Austin Thekkumthala, Helen G. Haggerty, Jennifer Wheeler, James Crona, Bojing Wang, Wendy J. Freebern, Rima Srour, Todd Bunch
Publikováno v:
Molecular Cancer Therapeutics. 17:LB-B33
Ipilimumab is a fully human immunoglobulin G1 (IgG1) monoclonal antibody against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), an inhibitory receptor expressed on activated effector T cells and regulatory T cells (Treg), that inhibits the bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5385f6d170db41c1396b6caf19a6e0b8
https://doi.org/10.1158/1535-7163.targ-17-lb-b33
https://doi.org/10.1158/1535-7163.targ-17-lb-b33
Autor:
M. G. Mense, Stephen K. Durham, Carla L. Bregman, P. C. Howroyd, Wendy J. Freebern, Jochen Woicke, Anthony M. Fletcher, Hengsheng Fang, R. W. Diters, Vito G. Sasseville
Publikováno v:
Veterinary Pathology. 44:407-410
Subendothelial heart valve angiectasis has been reported in cows, dogs, pigs, rats, mice, and in human fetuses and newborns. We observed a high incidence (62 in 208 animals examined) of spontaneous angiectasis on the atrioventricular (AV) valves in 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f27051553792091d722aa6f1604afe1
https://doi.org/10.1354/vp.44-3-407
https://doi.org/10.1354/vp.44-3-407
Autor:
Wayne G. Butscher, Ernest S. Kawasaki, Wendy J. Freebern, Adriana De Siervi, James L. Smith, Irene Collins, Cynthia M. Haggerty, Markey C. McNutt, David Petersen, Kevin Gardner, Juanita L. Merchant, Inna Dzekunova, Idalia Montano
Publikováno v:
Proceedings of the National Academy of Sciences. 101:11554-11559
Understanding the language encrypted in the gene regulatory regions of the human genome is a challenging goal for the genomic era. Although customary extrapolations from steady-state mRNA levels have been effective, deciphering these regulatory codes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c9a4d343e60a9cc15a8551d5780d325
https://doi.org/10.1073/pnas.0402156101
https://doi.org/10.1073/pnas.0402156101
Autor:
Wendy J. Freebern, Michael R. Emmert-Buck, Kevin Gardner, Dan-Paul Hartmann, Vladimir Knezevic, Arun Ramesh, Mikhail M. Galperin, June L. Traicoff, Cynthia M. Haggerty
Publikováno v:
BioTechniques. 36:1046-1051
The molecular profiles of protein expression from hundreds of cell lysates can be determined in a high-throughput manner by using fluorescent bead technologies, enzyme-linked immunosorbent assays (ELISAs), and protein microarrays. Although powerful,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f7211c4f15942dd3b90cfd884ec71b
https://doi.org/10.2144/04366pf01
https://doi.org/10.2144/04366pf01