Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Wendy J. Coutie"'
Publikováno v:
European Journal of Clinical Pharmacology. 58:643-647
The responsiveness to inhaled corticosteroid varies among individual asthmatic patients. It is not known, however, whether the effects of corticosteroids on one bodily tissue reflect the response in another in a given individual. The aim was to a ass
Publikováno v:
Clinical & Experimental Allergy. 32:126-132
Background The combination of montelukast (ML) and loratadine (LT) has previously been shown to be superior to either drug alone in managing seasonal allergic rhinitis (SAR), whilst fexofenadine (FEX) has been shown to be better than LT as monotherap
Publikováno v:
European Journal of Clinical Pharmacology. 57:637-641
High-dose nebulised fluticasone propionate (FP) has been advocated for use in patients with severe persistent asthma. As there is complete first-pass inactivation of FP for the swallowed fraction, systemic absorption is due solely to its lung bioavai
Publikováno v:
Chest. 116:935-940
Inhaled corticosteroids such as fluticasone propionate (FP) have dose-related systemic effects, including adrenal suppression. We have therefore investigated the effect of adding a large volume spacer on the systemic bioactivity of FP given via a pre
Publikováno v:
British Journal of Clinical Pharmacology. 48:355-360
Aims We wished to see if renin release in man was inhibited by nitric oxide blockade, suggesting a role for nitric oxide in renin release. Evidence from animal studies has shown variable effects on renin release depending on the model and stimulus us
Publikováno v:
Thorax. 54:614-617
BACKGROUND—Inhaled corticosteroids have dose related systemic effects determined by oral (swallowed or oropharyngeal absorption) and lung bioavailability. A study was undertaken to evaluate the significance of oropharyngeal absorption for fluticaso
Publikováno v:
Heart. 75:576-581
OBJECTIVE: To assess the differential effects of low dose (5 mg) and high dose (20 mg) lisinopril treatment on cardiovascular hormones, renal function, and blood pressure over 24 hours in patients with heart failure. DESIGN: Double-blind crossover st
Autor:
Allan D. Struthers, N Kennedy, Abdelwahab A. Naas, Neil C. Davidson, Jacqueline K. Hanson, Wendy J. Coutie
Publikováno v:
The American Journal of Cardiology. 77:828-831
We have directly compared atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and N-terminal pro-ANP (N-ANP) as markers of patients with left ventricular ejection fraction (LVEF)or = 35%, as measured by radionuclide ventriculography.
Publikováno v:
European Journal of Applied Physiology and Occupational Physiology. 72:256-260
We have studied the integrated neuroendocrine and haemodynamic effects of acute hypoxaemia in ten healthy volunteers studied on two separate occasions. After reaching a resting haemodynamic state, subjects breathed either room air or a nitrogen/oxyge
Publikováno v:
European Heart Journal. 16:1710-1715
Doppler echocardiographic indices of diastolic function and systemic haemodynamics were studied in response to infusions of atrial natriuretic peptide (0.5, 1, 2, 5 pmol.kg-1.min-1) and placebo (0.9% (w/v) saline) in ten normal male subjects. Compare