Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Wendy J. C. Prager‐van der Smissen"'
Autor:
Marcel Smid, Marjanka K. Schmidt, Wendy J. C. Prager-van der Smissen, Kirsten Ruigrok-Ritstier, Maartje A. C. Schreurs, Sten Cornelissen, Aida Marsal Garcia, Annegien Broeks, A. Mieke Timmermans, Anita M. A. C. Trapman-Jansen, J. Margriet Collée, Muriel A. Adank, Maartje J. Hooning, John W. M. Martens, Antoinette Hollestelle
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-14 (2023)
Abstract Background CHEK2 c.1100delC was the first moderate-risk breast cancer (BC) susceptibility allele discovered. Despite several genomic, transcriptomic and functional studies, however, it is still unclear how exactly CHEK2 c.1100delC promotes t
Externí odkaz:
https://doaj.org/article/8c35660b50404179bb0c665e16566e2a
Autor:
Titia G. Meijer, John W. M. Martens, Wendy J. C. Prager-van der Smissen, Nicole S. Verkaik, Corine M. Beaufort, Stanley van Herk, Teresa Robert-Finestra, Remco M. Hoogenboezem, Kirsten Ruigrok-Ritstier, Maarten W. Paul, Joost Gribnau, Eric M. J. Bindels, Roland Kanaar, Agnes Jager, Dik C. van Gent, Antoinette Hollestelle
Publikováno v:
Cancers, Vol 16, Iss 4, p 741 (2024)
Tumors with a pathogenic BRCA1/2 mutation are homologous recombination (HR)-deficient (HRD) and consequently sensitive to platinum-based chemotherapy and Poly-[ADP-Ribose]-Polymerase inhibitors (PARPi). We hypothesized that functional HR status bette
Externí odkaz:
https://doaj.org/article/f0adf102e7004b4299d9e0559ed350c1
Autor:
Shuoying Qu, A. Mieke Timmermans, Bernadette A. M. Heemskerk-Gerritsen, Anita M. A. C. Trapman-Jansen, Renée Broeren-Foekens, Wendy J. C. Prager-van der Smissen, Hoesna El Hassnaoui, Tim van Tienhoven, Claudia K. Bes-Stobbe, Pieter J. Westenend, Carolien H. M. van Deurzen, John W. M. Martens, Maartje J. Hooning, Antoinette Hollestelle
Publikováno v:
Cancers, Vol 16, Iss 1, p 28 (2023)
The ferritin-heavy chain (FTH1) is the catalytic subunit of the ferroxidase ferritin, which prevents oxidative DNA damage via intracellular iron storage. FTH1 was shown to be a prognostic marker for triple-negative breast cancer (BC) patients and ass
Externí odkaz:
https://doaj.org/article/429258d99040435092040aea788a11a9
Autor:
Teoman Deger, Pauline A. J. Mendelaar, Jaco Kraan, Wendy J. C. Prager‐van der Smissen, Michelle van derVlugt‐Daane, Eric M. J. Bindels, Anieta M. Sieuwerts, Stefan Sleijfer, Saskia M. Wilting, Antoinette Hollestelle, John W. M. Martens
Publikováno v:
Molecular Oncology, Vol 16, Iss 16, Pp 2981-3000 (2022)
Intrapatient tumour heterogeneity is likely a major determinant of clinical outcome in cancer patients. To assess heterogeneity in a minimally invasive manner, methods to perform single circulating tumour cell (CTC) genomics at high resolution are ne
Externí odkaz:
https://doaj.org/article/670fed1d4b0e407da90d1dd04df95007
Autor:
Anna E. M. Bastiaansen, A. Mieke Timmermans, Marcel Smid, Carolien H. M. van Deurzen, Esther S. P. Hulsenboom, Wendy J. C. Prager-van der Smissen, Renée Foekens, Anita M. A. C. Trapman-Jansen, Peter A. E. Sillevis Smitt, Theo M. Luider, John W. M. Martens, Martijn M. vanDuijn
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target. We examined the prevalence mGluR1 expression in different clinically releva
Externí odkaz:
https://doaj.org/article/857bf571bd7b4be593d8884fd1a9208e
Autor:
Marcel Smid, F. Germán Rodríguez-González, Anieta M. Sieuwerts, Roberto Salgado, Wendy J. C. Prager-Van der Smissen, Michelle van der Vlugt-Daane, Anne van Galen, Serena Nik-Zainal, Johan Staaf, Arie B. Brinkman, Marc J. van de Vijver, Andrea L. Richardson, Aquila Fatima, Kim Berentsen, Adam Butler, Sancha Martin, Helen R. Davies, Reno Debets, Marion E. Meijer-Van Gelder, Carolien H. M. van Deurzen, Gaëtan MacGrogan, Gert G. G. M. Van den Eynden, Colin Purdie, Alastair M. Thompson, Carlos Caldas, Paul N. Span, Peter T. Simpson, Sunil R. Lakhani, Steven Van Laere, Christine Desmedt, Markus Ringnér, Stefania Tommasi, Jorunn Eyford, Annegien Broeks, Anne Vincent-Salomon, P. Andrew Futreal, Stian Knappskog, Tari King, Gilles Thomas, Alain Viari, Anita Langerød, Anne-Lise Børresen-Dale, Ewan Birney, Hendrik G. Stunnenberg, Mike Stratton, John A. Foekens, John W. M. Martens
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Recent studies using in depth DNA sequencing techniques led to the identification of cancer driver genes but mainly focused on the effect on their expression. Here, the authors analyse 266 cases of breast cancer and report gene expression signatures
Externí odkaz:
https://doaj.org/article/0b80834b0f74411a8fac98a9ae2db59b
Autor:
Steven Van Laere, Colin A. Purdie, John A. Foekens, Gaëten MacGrogan, Marcel Smid, Andrew Futreal, Vanja de Weerd, Paul N. Span, Marc J. van de Vijver, Jorunn E. Eyfjord, Serena Nik-Zainal, F. Germán Rodríguez-González, Roberto Salgado, Peter T. Simpson, Christine Desmedt, Wendy J. C. Prager-van der Smissen, Fred C.G.J. Sweep, Tari A. King, Adam Butler, Michael R. Stratton, Carlos Caldas, Gert Van den Eynden, Sunil R. Lakhani, Saskia M. Wilting, Alastair M. Thompson, Angelo Paradiso, John W.M. Martens, Anne Vincent-Salomon, Johan Staaf, Anne van Galen, Sancha Martin, Hendrik G. Stunnenberg, Annegien Broeks, Andrea L. Richardson, Anne Lise Børresen-Dale, Helen Davies, Michelle van der Vlugt-Daane, Katharina Uhr, Stian Knappskog, Alain Viari, Anieta M. Sieuwerts
Publikováno v:
Genome Research
Genome Research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome Research, Cold Spring Harbor Laboratory Press, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Genome Research, 29, 356-366
Genome research, 29 (3
Genome research
Genome Research, 29, 3, pp. 356-366
Genome Research, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Genome Research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome research, 29(3), 356-366. Cold Spring Harbor Laboratory Press
Genome Research, Cold Spring Harbor Laboratory Press, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Genome Research, 29, 356-366
Genome research, 29 (3
Genome research
Genome Research, 29, 3, pp. 356-366
Genome Research, 2019, 29 (3), pp.356-366. ⟨10.1101/gr.238121.118⟩
Publisher's version (útgefin grein)
Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to id
Circular RNAs (circRNAs) are a class of RNAs that is under increasing scrutiny, although their functional roles are debated. We analyzed RNA-seq data of 348 primary breast cancers and developed a method to id
Autor:
Renée Foekens, Wendy J. C. Prager-van der Smissen, Marcel Smid, Peter A. E. Sillevis Smitt, A. Mieke Timmermans, Carolien H.M. van Deurzen, Esther Hulsenboom, Anita M. A. C. Trapman-Jansen, John W.M. Martens, Martijn M. VanDuijn, Anna E M Bastiaansen, Theo M. Luider
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, 10(1):22292. Nature Publishing Group
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, 10(1):22292. Nature Publishing Group
New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target. We examined the prevalence mGluR1 expression in different clinically relevant breast
Autor:
John A. Foekens, Agnes Jager, John W.M. Martens, Anouk A. J. Heine, Marijn T.M. van Jaarsveld, Erik A.C. Wiemer, Wendy J. C. Prager-van der Smissen, Antonius W. M. Boersma, Bahar Ozturk, Marcel Smid, Katharina Uhr
Publikováno v:
PLoS ONE
PLoS One (online), 14(5):e0216400. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216400 (2019)
PLoS One (online), 14(5):e0216400. Public Library of Science
PLoS ONE, Vol 14, Iss 5, p e0216400 (2019)
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally. In this way they might influence whether a cell is sensitive or resistant to a certain drug. So far, only a limited number of relatively small scale studies comprising few cell lines
Autor:
John W.M. Martens, Maxime P. Look, Antoinette Hollestelle, Wendy J. C. Prager van der Smissen, Marcel Smid, Marion E. Meijer-van Gelder, Jingjing Liu, Anieta M. Sieuwerts, John A. Foekens
Publikováno v:
Cancer Letters, 376(1), 104-109. Elsevier Ireland Ltd
In breast cancer, GATA3 mutations have been associated with a favorable prognosis and the response to neoadjuvant aromatase inhibitor treatment. Therefore, we investigated whether GATA3 mutations predict the outcome of tamoxifen treatment in the adva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d524fb69413f5fe90a577d9eabd6c14
https://pure.eur.nl/en/publications/dfa3790b-7891-41ed-a2a9-b6f759e97c36
https://pure.eur.nl/en/publications/dfa3790b-7891-41ed-a2a9-b6f759e97c36