Výsledky vyhledávání - "Wendy J. Bailey"

Akademický článek

Live Viral Vaccine Neurovirulence Screening: Current and Future Models

Autor: Corey May Fulton, Wendy J. Bailey

Publikováno v: Vaccines, Vol 9, Iss 7, p 710 (2021)

Live viral vaccines are one of the most successful methods for controlling viral infections but require strong evidence to indicate that they are properly attenuated. Screening for residual neurovirulence is an important aspect for live viral vaccine

Externí odkaz: https://doaj.org/article/940a7aa210ac4949b112ab1c93bff3a8

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Supplementary Tables S1 and S2 from Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells

Supplementary tables listing the affinities and bioactivities of MK-4166 and DTA-1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249f3473bfc76fc6a9343fe15e701207
https://doi.org/10.1158/0008-5472.22414407.v1

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Supplementary Methods from Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells

This file contains supplementary methods that describe the antibodies used, the generation and characterization of MK-4166, various cell-based assays, and the evaluation of toxicity in cynomolgus monkeys.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69827d21a8c9e0175677d7a8489838f7
https://doi.org/10.1158/0008-5472.22414410.v1

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Data from Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells

GITR is a T-cell costimulatory receptor that enhances cellular and humoral immunity. The agonist anti-mouse GITR antibody DTA-1 has demonstrated efficacy in murine models of cancer primarily by attenuation of Treg-mediated immune suppression, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5bfee5aa1afeba34ec05f3cba4f5fee8
https://doi.org/10.1158/0008-5472.c.6508965.v1

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Supplementary Figures S1 through S10 from Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells

Supplementary Figure S1 shows the gating scheme and markers used to phenotype various T cell subsets in human blood. Supplementary Figure S2 shows the expression of GITR on human and cynomolgus monkey NK cells and T cells. Supplementary Figure S3 sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b1719210763f1f05971391ff03d06a
https://doi.org/10.1158/0008-5472.22414413.v1

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Universal Accessible Biomarkers of Drug-Induced Tissue Injury and Systemic Inflammation in Rat: Performance Assessment of TIMP-1, A2M, AGP, NGAL, and Albumin

Autor: Katerina, Vlasakova, Jennifer, Bourque, Wendy J, Bailey, Shetal, Patel, Elizabeth G, Besteman, Raymond J, Gonzalez, Frank D, Sistare, Warren E, Glaab

Publikováno v: Toxicological Sciences. 187:219-233

The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would provide a valuable tool in early exploratory animal studies to understand potential drug liabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b063b32a14b4046a9ff7c68d7d3fd6a5
https://doi.org/10.1093/toxsci/kfac030

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Strategies and Recommendations for Using a Data‐Driven and Risk‐Based Approach in the Selection of First‐in‐Human Starting Dose: An International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) Assessment

Autor: Chao Han, Marque Todd, Chunze Li, Frank R. Brennan, Zheng Yang, Sherri Dudal, Wendy J. Bailey, Yingxue Chen, Nagendra V. Chemuturi, Kapil Mayawala, Lise I. Loberg, Antoine Deslandes, Clarke David O, Michael W. Leach, Mark Rogge

Publikováno v: Clinical Pharmacology & Therapeutics. 109:1395-1416

Various approaches to first-in-human (FIH) starting dose selection for new molecular entities (NMEs) are designed to minimize risk to trial subjects. One approach uses the minimum anticipated biological effect level (MABEL), which is a conservative m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b9ae8f92d0d96e2c0c7071ecc9d48d
https://doi.org/10.1002/cpt.2009

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Universal Toxicity Gene Signatures for Early Identification of Drug-Induced Tissue Injuries in Rats

Autor: Thomas R. Skopek, Warren E. Glaab, Laura Michna, Carolann Beare, Wendy J. Bailey, Frank D. Sistare, Daniel J. Holder, Nagaraja Muniappa, David Gerhold, Joseph F. Sina, Yudong D He, Jeffrey W. Lawrence, Zoltan Erdos, Pamela Lane, Keith Q. Tanis

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 181(2)

A new safety testing paradigm that relies on gene expression biomarker panels was developed to easily and quickly identify drug-induced injuries across tissues in rats prior to drug candidate selection. Here, we describe the development, qualificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d035f511764e56dbc4c0a33dd1ef1df
https://pubmed.ncbi.nlm.nih.gov/33837425

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Moving toward a principle-based approach to U.S. accounting standard setting: A demand for procedural justice and accounting reform

Autor: Kimberly M. Sawers, Wendy J. Bailey

Publikováno v: Advances in Accounting. 43:1-13

In the wake of numerous accounting scandals in the early 2000s, the U.S. began considering a move away from a more rule-based approach to accounting standard setting and toward a more principle-based approach to accounting standard setting. Although

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3f8efdc643df245d0ecd0c5c575ddce
https://doi.org/10.1016/j.adiac.2018.07.006

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Analyzing Two Investments—An Instructional Case to Introduce Basic Financial Accounting Concepts

Autor: Janet A. Samuels, Wendy J. Bailey

Publikováno v: Issues in Accounting Education. 33:47-56

This case introduces basic financial accounting concepts to graduate business students in an accounting orientation session (i.e., “boot camp”). Students assume they have invested in two cupcake businesses in Paris and they now want to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03fc606e6d3665d56307618b16e77549
https://doi.org/10.2308/iace-52254

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