Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Wendy H, Gough"'
Autor:
Kristy Kikly, Howard Barff Broughton, William Chang, Selma Sapmaz, Richard Morphy, Holly A. Bina, Jim D. Durbin, Sherry Y Guo, Timothy Ivo Richardson, Jimmy P Steele, Ryan Edward Stites, Brian G. Getman, Vaught Grant Matthews, Veavi Ching-Yun Chang, Pamela K. Shetler, Greg L Durst, Denise D Edmondson, Rob Barr, Helene Rudyk, Charles Willis Lugar, Nita J. Patel, Christian Alexander Clarke, Kelly Wayne Furness, Nicole E New, David K. Clawson, Keith R. Stayrook, Mark Chambers, Brian Michael Mathes, Stephanie L. Stout, Wendy H. Gough
Publikováno v:
Journal of Medicinal Chemistry. 64:5470-5484
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a80dc241f7e50c8ddb367cc37ea913c
https://doi.org/10.1021/acs.jmedchem.0c01918
https://doi.org/10.1021/acs.jmedchem.0c01918
Autor:
Beverly L Falcon, Michelle Swearingen, Wendy H Gough, Linda Lee, Robert Foreman, Mark Uhlik, Jeff C Hanson, Jonathan A Lee, Don B McClure, Sudhakar Chintharlapalli
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106901 (2014)
Vascular endothelial growth factor (VEGF) plays a dominant role in angiogenesis. While inhibitors of the VEGF pathway are approved for the treatment of a number of tumor types, the effectiveness is limited and evasive resistance is common. One mechan
Externí odkaz:
https://doaj.org/article/da954fc5fdb943c6baa8aa37fcd78d65
Autor:
Charles W, Lugar, Christian A, Clarke, Richard, Morphy, Helene, Rudyk, Selma, Sapmaz, Ryan E, Stites, Grant M, Vaught, Kelly, Furness, Howard B, Broughton, Greg L, Durst, David K, Clawson, Stephanie L, Stout, Sherry Y, Guo, Jim D, Durbin, Keith R, Stayrook, Denise D, Edmondson, Kristy, Kikly, Nicole E, New, Holly A, Bina, Mark G, Chambers, Pamela, Shetler, William Y, Chang, Veavi Ching-Yun, Chang, Rob, Barr, Wendy H, Gough, Jimmy P, Steele, Brian, Getman, Nita, Patel, Brian M, Mathes, Timothy I, Richardson
Publikováno v:
Journal of medicinal chemistry. 64(9)
The Th17 pathway has been implicated in autoimmune diseases. The retinoic acid receptor-related orphan receptor C2 (RORγt) is a master regulator of Th17 cells and controls the expression of IL-17A. RORγt is expressed primarily in IL-17A-producing l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef03d39fb502b855beadc34c7a19e1e7
https://pubmed.ncbi.nlm.nih.gov/33852312
https://pubmed.ncbi.nlm.nih.gov/33852312
Autor:
Yao-Chang Xu, Brian Michael Mathes, John Mehnert Schaus, Qi Chen, Maria-Jesus Blanco, Suzanne E. Nutter, David L. Nelson, Deanna Piatt Zacherl, Sidney Xi Liang, Sandra Ann Filla, Wendy H. Gough, Cohen Michael Philip, Kevin John Hudziak, Bai-Ping Ying, Deyi Zhang, Joseph H. Krushinski, Daniel Timothy Kohlman, Frantz Victor, David B. Wainscott
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4337-4341
Preclinical experiments and clinical observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb9cce22ae638ea7e986f92d8e3a6dba
https://doi.org/10.1016/j.bmcl.2015.07.042
https://doi.org/10.1016/j.bmcl.2015.07.042
Autor:
Francis S. Willard, Jonathan A. Lee, Christopher M. Moxham, Tamika D. Meredith, Robert B. Peery, Karen Leigh Cox, Sarah E. Oliver, Jennifer Oler, Steven A. Heidler, Rachelle J. Sells Galvin, Wendy H. Gough, Alan David Palkowitz, Shaoyou Chu, Saba Husain
Publikováno v:
SLAS Discovery. 16:588-602
Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2265c06651bbb3fcdfa65d1c83fae79d
https://doi.org/10.1177/1087057111405379
https://doi.org/10.1177/1087057111405379
Autor:
Deyi, Zhang, Maria-Jesus, Blanco, Bai-Ping, Ying, Daniel, Kohlman, Sidney X, Liang, Frantz, Victor, Qi, Chen, Joseph, Krushinski, Sandra A, Filla, Kevin J, Hudziak, Brian M, Mathes, Michael P, Cohen, DeAnna, Zacherl, David L G, Nelson, David B, Wainscott, Suzanne E, Nutter, Wendy H, Gough, John M, Schaus, Yao-Chang, Xu
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(19)
Preclinical experiments and clinical observations suggest the potential effectiveness of selective 5-HT1F receptor agonists in migraine. Identifying compounds with enhanced selectivity is crucial to assess its therapeutic value. Replacement of the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::143e37bcd53bad4bd106dfa8f1aa2e9b
https://pubmed.ncbi.nlm.nih.gov/26271587
https://pubmed.ncbi.nlm.nih.gov/26271587
Autor:
Maciej J. Zamek-Gliszczynski, Liang Zeng Yan, Yu-Hua Hui, Lisa Kays, Julie Stewart, John A. Wijsman, Donald C. Paul, Kelly M. Credille, Wendy H. Gough, Xiaoyi Zhang, Qi Chen, Sheng-Bin Peng, Mark Uhlik
Publikováno v:
Molecular cancer therapeutics. 14(2)
Emerging evidence demonstrates that stromal cell-derived factor 1 (SDF-1) and CXCR4, a chemokine and chemokine receptor pair, play important roles in tumorigenesis. In this report, we describe a small cyclic peptide, LY2510924, which is a potent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5276e369fdb0c24de3cb34e0cbc53412
https://pubmed.ncbi.nlm.nih.gov/25504752
https://pubmed.ncbi.nlm.nih.gov/25504752
Autor:
David B. Wainscott, John Mehnert Schaus, Wendy H. Gough, Yao-Chang Xu, Brian Michael Mathes, John M. Zgombick, Sandra Ann Filla, David L. Nelson, Suzanne E. Nutter, Kevin John Hudziak, Theresa Branchek
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:167-170
Synthesis and evaluation of a series of 2,3,5- and 3,5-substituted furo[3,2- b ]pyridines were undertaken in order to investigate their utility as bioisosteres of 5-HT 1F receptor agonist indole analogues, 1 – 3 . The replacement proved to be effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f54d2bf69e2efd475b2e1773ee1f9f4
https://doi.org/10.1016/j.bmcl.2003.09.091
https://doi.org/10.1016/j.bmcl.2003.09.091
Publikováno v:
Journal of Biological Chemistry. 276:22278-22286
We report characterization of a novel member of the short chain dehydrogenase/reductase superfamily. The 1513-base pair cDNA encodes a 319-amino acid protein. The corresponding gene spans over 26 kilobase pairs on chromosome 2 and contains five exons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c882537ce0628326ff3b4f059cc5909
https://doi.org/10.1074/jbc.m102076200
https://doi.org/10.1074/jbc.m102076200
Autor:
Ting-Kai Li, Natalia Y. Kedishvili, William F. Bosron, Wilhelmina I. Davis, Wendy H. Gough, Steven G. Parsons
Publikováno v:
Biochemical and Biophysical Research Communications. 249:191-196
All-trans retinoic acid (atRA) is a powerful morphogen synthesized in a variety of tissues. Oxidation of all-trans retinol to all-trans retinal determines the overall rate of atRA biosynthesis. This reaction is catalyzed by multiple dehydrogenases in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a4353f11e7595072b6d79c55ce60b6
https://doi.org/10.1006/bbrc.1998.9105
https://doi.org/10.1006/bbrc.1998.9105