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of 10
pro vyhledávání: '"Wendy G. Tan"'
Autor:
Wendy G Tan, Iryna Zubkova, Alla Kachko, Frances Wells, Heiko Adler, Gerd Sutter, Marian E Major
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0181578 (2017)
T-cell based vaccines have been considered as attractive candidates for prevention of hepatitis C virus (HCV) infections. In this study we compared the magnitude and phenotypic characteristics of CD8+ T-cells induced by three commonly used viral vect
Externí odkaz:
https://doaj.org/article/2229ae1085654a6284af5f2bf284757e
Autor:
Gerd Sutter, Iryna Zubkova, Marian E. Major, Wendy G. Tan, Frances Wells, Alla Kachko, Heiko Adler
Publikováno v:
PLoS ONE 12:e0181578 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181578 (2017)
PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181578 (2017)
T-cell based vaccines have been considered as attractive candidates for prevention of hepatitis C virus (HCV) infections. In this study we compared the magnitude and phenotypic characteristics of CD8+ T-cells induced by three commonly used viral vect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99cf25e33348cccd10576e6cf39596ae
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51566
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=51566
Autor:
Erin E. West, Ben Youngblood, Wendy G. Tan, Pablo Penaloza-MacMaster, Ata Ur Rasheed, Rafi Ahmed, Sang Jun Ha, Kendall A. Smith, Hyun Tak Jin, Gordon J. Freeman
Publikováno v:
Journal of Clinical Investigation. 123:2604-2615
The inhibitory receptor programmed cell death 1 (PD-1) plays a major role in functional exhaustion of T cells during chronic infections and cancer, and recent clinical data suggest that blockade of the PD-1 pathway is an effective immunotherapy in tr
Autor:
Wendy G. Tan, Pablo Penaloza-MacMaster, Erin E. West, Michael J. Zilliox, Andreas Wieland, Hyun Tak Jin, Rafi Ahmed, M. Juliana McElrath, Dan H. Barouch
Publikováno v:
Journal of Virology. 87:1359-1372
Adenovirus (Ad) vectors are widely used as experimental vaccines against several infectious diseases, but the magnitude, phenotype, and functionality of CD8 + T cell responses induced by different adenovirus serotypes have not been compared. To addre
Autor:
Koichi Araki, Rafi Ahmed, Tuoqi Wu, Weiyan Li, Junghwa Lee, J. Scott Hale, Lilin Ye, Wendy G. Tan, Ata-Ur-Rasheed Mohammed, Carl W. Davis, Lifan Xu
Publikováno v:
Journal of virology. 91(4)
mTOR has important roles in regulation of both innate and adaptive immunity, but whether and how mTOR modulates humoral immune responses have yet to be fully understood. To address this issue, we examined the effects of rapamycin, a specific inhibito
Autor:
Rafi Ahmed, Bogumila T. Konieczny, W. Nicholas Haining, Wendy G. Tan, Gordon J. Freeman, Silvia Calpe, Cox Terhorst, Benjamin Youngblood, Erin E. West, Koichi Araki, Gabriela Alexe, Hyun-Tak Jin
Publikováno v:
Immunity. 35:285-298
To design successful vaccines for chronic diseases, an understanding of memory CD8+ T cell responses to persistent antigen re-stimulation is critical. However, most studies comparing memory and naïve cell responses have only been performed in rapidl
Autor:
Wendy G. Tan, Koichi Araki, Rafi Ahmed, Ana C. Anderson, Gordon J. Freeman, Erin E. West, Sang Jun Ha, Vijay K. Kuchroo, Hyun Tak Jin
Publikováno v:
Proceedings of the National Academy of Sciences. 107:14733-14738
Inhibitory receptors play a crucial role in regulating CD8 T-cell function during chronic viral infection. T-cell Ig- and mucin-domain–containing molecule–3 (Tim-3) is well known to negatively regulate T-cell responses, but its role in CD8 T-cell
Autor:
Steven A. Rubin, Iryna Zubkova, Carole A. Bewley, Marian E. Major, Syed Shahzad-ul-Hussan, Kazuyo Takeda, Sandra Loesgen, Wendy G. Tan, Alla Kachko, Frances Wells
Publikováno v:
Molecular pharmaceutics. 10(12)
Plant or microbial lectins are known to exhibit potent antiviral activities against viruses with glycosylated surface proteins, yet the mechanism(s) by which these carbohydrate-binding proteins exert their antiviral activities is not fully understood
Autor:
Rafi Ahmed, Zoher F. Kapasi, Smita S. Iyer, E. John Wherry, Todd C. Becker, Janel Hart Chatraw, Wendy G. Tan
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 188(1)
Nutrition is a critical but poorly understood determinant of immunity. There is abundant epidemiological evidence linking protein malnutrition to impaired vaccine efficacy and increased susceptibility to infections; yet, the role of dietary protein i
Autor:
Wendy G. Tan, Erica N. Borducchi, Dan H. Barouch, P. Penaloza, Anna McNally, Nathaniel L. Simmons, Nicholas M. Provine, Rafi Ahmed, Jeffrey E. Teigler
Publikováno v:
Retrovirology, Vol 9, Iss Suppl 2, p P246 (2012)
Retrovirology
Retrovirology
Background The anamnestic potential of memory T cells are pivotal components of the adaptive immune response. Analyzing memory T cells elicited by different vaccine vectors is crucial for the identification of novel vaccine modalities against HIV. Me