Výsledky vyhledávání - "Wendy DuBois"

Akademický článek

WDR26 and MTF2 are therapeutic targets in multiple myeloma

Autor: Fumou Sun, Yan Cheng, Jesse D. Riordan, Adam Dupuy, Wendy Dubois, Michael Pisano, Jing Dong, Beverly Mock, Fenghuang Zhan, Parameswaran Hari, Siegfried Janz

Publikováno v: Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-7 (2021)

Abstract Unbiased genetic forward screening using retroviral insertional mutagenesis in a genetically engineered mouse model of human multiple myeloma may further our understanding of the genetic pathways that govern neoplastic plasma cell developmen

Externí odkaz: https://doaj.org/article/e3500f2676bd455a95eca8832206d940

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Akademický článek

Host CLIC4 expression in the tumor microenvironment is essential for breast cancer metastatic competence.

Autor: Vanesa C Sanchez, Howard H Yang, Alayna Craig-Lucas, Wendy Dubois, Brandi L Carofino, Justin Lack, Jennifer E Dwyer, R Mark Simpson, Christophe Cataisson, Max P Lee, Ji Luo, Kent W Hunter, Stuart H Yuspa

Publikováno v: PLoS Genetics, Vol 18, Iss 6, p e1010271 (2022)

The TGF-β-regulated Chloride Intracellular Channel 4 (CLIC4) is an essential participant in the formation of breast cancer stroma. Here, we used data available from the TCGA and METABRIC datasets to show that CLIC4 expression was higher in breast ca

Externí odkaz: https://doaj.org/article/a8c9af69453d42e7a8a1e57bff679371

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Akademický článek

CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer.

Autor: Navdeep Malik, Hualong Yan, Howard H Yang, Gamze Ayaz, Wendy DuBois, Yu-Chou Tseng, Young-Im Kim, Shunlin Jiang, Chengyu Liu, Maxwell Lee, Jing Huang

Publikováno v: PLoS Genetics, Vol 17, Iss 5, p e1009553 (2021)

The CBFB gene is frequently mutated in several types of solid tumors. Emerging evidence suggests that CBFB is a tumor suppressor in breast cancer. However, our understanding of the tumor suppressive function of CBFB remains incomplete. Here, we analy

Externí odkaz: https://doaj.org/article/bd92132d66e74b4e8fce16a33bde98e7

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Akademický článek

mTOR intersects antibody-inducing signals from TACI in marginal zone B cells

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)

Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching

Externí odkaz: https://doaj.org/article/55fa5c77ea474673980a024897c7214c

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Akademický článek

cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma

Autor: Yunlong He, Wentao Zhu, Min Hwa Shin, Joy Gary, Chengyu Liu, Wendy Dubois, Shelley B. Hoover, Shunlin Jiang, Eryney Marrogi, Beverly Mock, R. Mark Simpson, Jing Huang

Publikováno v: Stem Cell Reports, Vol 8, Iss 6, Pp 1630-1644 (2017)

Bone marrow-derived mesenchymal stem cells (BMSCs) are proposed as the cells of origin of several subtypes of osteosarcoma (OS). However, signals that direct BMSCs to form different subtypes of OS are unclear. Here we show that the default tumor type

Externí odkaz: https://doaj.org/article/cf90561569b445598bdb324e83a3f4a3

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Akademický článek

Conventional Co-Housing Modulates Murine Gut Microbiota and Hematopoietic Gene Expression

Autor: Jichun Chen, Shuling Zhang, Xingmin Feng, Zhijie Wu, Wendy Dubois, Vishal Thovarai, Sonia Ahluwalia, Shouguo Gao, Jinguo Chen, Tyler Peat, Shurjo K. Sen, Giorgio Trinchieri, Neal S. Young, Beverly A. Mock

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 17, p 6143 (2020)

Specific-pathogen-free (SPF) mice have improved hematopoietic characteristics relative to germ-free mice, however, it is not clear whether improvements in hematopoietic traits will continue when the level of microorganism exposure is further increase

Externí odkaz: https://doaj.org/article/00fbe32dc0164d6388e4b9946d2f040d

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Akademický článek

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

Autor: J. Julie Wu, Jie Liu, Edmund B. Chen, Jennifer J. Wang, Liu Cao, Nisha Narayan, Marie M. Fergusson, Ilsa I. Rovira, Michele Allen, Danielle A. Springer, Cory U. Lago, Shuling Zhang, Wendy DuBois, Theresa Ward, Rafael deCabo, Oksana Gavrilova, Beverly Mock, Toren Finkel

Publikováno v: Cell Reports, Vol 4, Iss 5, Pp 913-920 (2013)

We analyzed aging parameters using a mechanistic target of rapamycin (mTOR) hypomorphic mouse model. Mice with two hypomorphic (mTORΔ/Δ) alleles are viable but express mTOR at approximately 25% of wild-type levels. These animals demonstrate reduced

Externí odkaz: https://doaj.org/article/8213b697016544c1aff5a5dfc267de9f

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Akademický článek

A Genome-wide Map of CTCF Multivalency Redefines the CTCF Code

Autor: Hirotaka Nakahashi, Kyong-Rim Kieffer Kwon, Wolfgang Resch, Laura Vian, Marei Dose, Diana Stavreva, Ofir Hakim, Nathanael Pruett, Steevenson Nelson, Arito Yamane, Jason Qian, Wendy Dubois, Scott Welsh, Robert D. Phair, B. Franklin Pugh, Victor Lobanenkov, Gordon L. Hager, Rafael Casellas

Publikováno v: Cell Reports, Vol 3, Iss 5, Pp 1678-1689 (2013)

The “CTCF code” hypothesis posits that CTCF pleiotropic functions are driven by recognition of diverse sequences through combinatorial use of its 11 zinc fingers (ZFs). This model, however, is supported by in vitro binding studies of a limited nu

Externí odkaz: https://doaj.org/article/8d3d3f59f89e43c5926c484dd8f1eb24

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