Výsledky vyhledávání - "Wendy Devereux"

A Primary Xenograft Model of Small-Cell Lung Cancer Reveals Irreversible Changes in Gene Expression Imposed by Culture In vitro

Autor: Charles M. Rudin, Craig D. Peacock, Rex C. Yung, Luigi Marchionni, Wendy Devereux, Jonathan T. Rhodes, Vincent C. Daniel, Marion Dorsch, Giovanni Parmigiani, Jared S. Hierman, D. Neil Watkins

Publikováno v: Cancer Research. 69:3364-3373

Traditional approaches to the preclinical investigation of cancer therapies rely on the use of established cell lines maintained in serum-based growth media. This is particularly true of small-cell lung cancer (SCLC), where surgically resected tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eabc6a640f9fcbc0e1f2d1881db8ceaf
https://doi.org/10.1158/0008-5472.can-08-4210

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Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

Autor: Wei Zhang, Ian M. Corcoran-Schwartz, Stephen B. Baylin, Charles G. Eberhart, Kimberly J. Briggs, Thomas Harcke, D. Neil Watkins, Wendy Devereux

Publikováno v: Genes & Development. 22:770-785

Medulloblastoma is an embryonal tumor thought to arise from the granule cell precursors (GCPs) of the cerebellum. PATCHED (PTCH), an inhibitor of Hedgehog signaling, is the best-characterized tumor suppressor in medulloblastoma. However, PTCH. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc4588395d8f2fda1023ceee9cffea8
https://doi.org/10.1101/gad.1640908

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A histological survey of green fluorescent protein expression in ‘green’ mice: implications for stem cell research

Autor: Lindsey J. Brown, Steven D. Leach, Cynthia A. Zahnow, Saul J. Sharkis, Stephen B. Baylin, Wendy Devereux, D. Neil Watkins, Sandra A. Biankin, Wolfram Kleeberger, Michael I. Collector, Andrew V. Biankin

Publikováno v: Pathology. 39:247-251

Summary Aims The transgenic enhanced green fluorescent protein (EGFP) expressing ‘green’ mouse (C57BL/6-TgN(ACTbEGFP)IOsb) is a widely used tool in stem cell research, where the ubiquitous nature of EGFP expression is critical to track the fate o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1716f6f68f00a2778ba78538271393
https://doi.org/10.1080/00313020701230807

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Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma

Autor: Gregory S. Gesell, William Matsui, Craig D. Peacock, Wendy Devereux, Carol Ann Huff, Philip A. Beachy, D. Neil Watkins, Evan Jones, Ian M. Corcoran-Schwartz, Qiuju Wang, Jonathan T. Rhodes, Jynho Kim

Publikováno v: Proceedings of the National Academy of Sciences. 104:4048-4053

The cancer stem cell hypothesis suggests that malignant growth depends on a subset of tumor cells with stem cell-like properties of self-renewal. Because hedgehog (Hh) signaling regulates progenitor cell fate in normal development and homeostasis, ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf77e911d2d6a8d81ee4e4cc6250491
https://doi.org/10.1073/pnas.0611682104

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Spermidine/spermine N1-acetyltransferase (SSAT) activity in human small-cell lung carcinoma cells following transfection with a genomic SSAT construct

Autor: Renee Smith, Amy Hacker, Yanlin Wang, Tracy Murray-Stewart, Robert A. Casero, Wendy Devereux, Nancy B Applegren

Publikováno v: Biochemical Journal. 373:629-634

Spermidine/spermine N1-acetyltransferase (SSAT) activity is typically highly inducible in non-small-cell lung carcinomas in response to treatment with anti-tumour polyamine analogues, and this induction is associated with subsequent cell death. In co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded52ff9debe19ccb941fbb30c68ac02
https://doi.org/10.1042/bj20021895

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Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics

Autor: Yanlin Wang, Robert A. Casero, Tracy Murray-Stewart, Wendy Devereux

Publikováno v: Biochemical Journal. 368:673-677

The recently cloned and characterized human polyamine oxidase (PAOh1) potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. Here the discovery of three a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1233aa8d7173663e2fc2a58999834941
https://doi.org/10.1042/bj20021587

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Cloning and characterization of the mouse polyamine-modulatedfactor-1 (mPMF-1) gene: an alternatively spliced homologue of the human transcription factor

Autor: Yanlin WANG, Wendy DEVEREUX, Patrick M. WOSTER, Robert A. CASERO

Publikováno v: Biochemical Journal. 359:387-392

The natural polyamines and their analogues have been implicated in transcriptional regulation of specific genes. Human polyamine-modulated factor-1 (hPMF-1) was the first polyamine-responsive transcription factor identified. Here the mouse homologue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c2f1af393d74672e25761768b916233
https://doi.org/10.1042/bj3590387

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Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene

Autor: Yanlin WANG, Wendy DEVEREUX, Tracy Murray STEWART, Robert A. CASERO

Publikováno v: Biochemical Journal. 355:45-49

Polyamines and polyamine analogues have been demonstrated to modulate the transcription of various genes. Spermidine/spermine N1-acetyltransferase (SSAT) is transcriptionally regulated through the interaction of at least two trans-acting transcriptio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14d5475c8a166b5af9bd5d29dccb3ad0
https://doi.org/10.1042/bj3550045

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A crucial requirement for Hedgehog signaling in small cell lung cancer

Publikováno v: Nature medicine. 17(11)

Small-cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer for which there is no effective treatment1,2. Using a mouse model in which deletion of Rb1 and Trp53 in the lung epithelium of adult mice induces SCLC3,4, we found t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a418574481b0ce95f12cd03b2508cb2
https://pubmed.ncbi.nlm.nih.gov/21983857

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Properties of purified recombinant human polyamine oxidase, PAOh1/SMO

Autor: Amy Hacker, Tracy Murray-Stewart, Patrick M. Woster, Benjamin Frydman, Yanlin Wang, Robert A. Casero, Wendy Devereux

Publikováno v: Biochemical and biophysical research communications. 304(4)

The discovery of an inducible oxidase whose apparent substrate preference is spermine indicates that polyamine catabolism is more complex than that originally proposed. To facilitate the study of this enzyme, the purification and characterization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c3aae814341b624eeb6f5f22741686
https://pubmed.ncbi.nlm.nih.gov/12727196

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