An observational study on intracutaneous sodium storage in intensive care patients and controls.

Autor: Marjolein van IJzendoorn, Jacob van den Born, Ryanne Hijmans, Rianne Bodde, Hanneke Buter, Wendy Dam, Peter Kingma, Gwendolyn Maes, Tsjitske van der Veen, Wierd Zijlstra, Baukje Dijkstra, Gerjan Navis, Christiaan Boerma

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0223100 (2019)

The development of ICU-acquired sodium disturbances is not fully understood. Alterations in non-osmotic skin sodium storage, hypothetically inflammation-driven, could play a role. To investigate this in critically ill patients we conducted a patient-

Externí odkaz: https://doaj.org/article/43fd2f27f756484183190a315e2da107

Circulating Vascular Endothelial Growth Factor (VEGF) Levels in Advanced Stage Cancer Patients Compared to Normal Controls and Diabetes Mellitus Patients with Critical Ischemia

Autor: Yoka H. Kusumanto, Coby Meijer, Wendy Dam, Nanno H. Mulder, Geke A.P. Hospers

Publikováno v: Drug Target Insights, Vol 2, Pp 105-109 (2007)

Anti-angiogenic therapy is emerging as a valuable tool in the treatment of patients with cancer. As VEGF is a central target in anti-angiogenic therapy, its levels in the circulation might be relevant in selecting tumor types or patients likely to re

Externí odkaz: https://doaj.org/article/0db588fd9f004c16a9e02fd6f6503d70

Machine-perfused donor kidneys as a source of human renal endothelial cells

Autor: Stefan P Berger, Lisanne M Lagendijk, Henri G. D. Leuvenink, Wendy Dam, Marc A. Seelen, Rosa G.M. Lammerts, Mohamed R. Daha, Gesa Tiller, Bouke G. Hepkema, Robert A. Pol, Harriet L Lancaster, Jacob van den Born, Grietje Molema

Publikováno v: American journal of physiology-Renal physiology, 320(5), F947-F962. AMER PHYSIOLOGICAL SOC

Renal endothelial cells (ECs) play crucial roles in vasorelaxation, ultrafiltration, and selective transport of electrolytes and water, but also in leakage of the glomerular filtration barrier and inflammatory processes like complement activation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2a81e12470c5f4262e209192ff6372
https://hdl.handle.net/11370/d0382597-e307-4873-9d44-8499150707b0

Direct Evidence of Endothelial Dysfunction and Glycocalyx Loss in Dermal Biopsies of Patients With Chronic Kidney Disease and Their Association With Markers of Volume Overload

Autor: Casper F. M. Franssen, Manuela Ossa Builes, Wendy Dam, Stephan J. L. Bakker, Ryanne S. Hijmans, Jacob van den Born, Josephine Koch, Robert A. Pol, Hendri H. Pas

Publikováno v: Frontiers in Cell and Developmental Biology, 9:733015, 1-13. Frontiers Media S.A.
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Cardiovascular morbidity is a major problem in patients with chronic kidney disease (CKD) and endothelial dysfunction (ED) is involved in its development. The luminal side of the vascular endothelium is covered by a protective endothelial glycocalyx

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350656ef8547acfa1e68d40c11567217

Properdin Pattern Recognition on Proximal Tubular Cells Is Heparan Sulfate/Syndecan-1 but Not C3b Dependent and Can Be Blocked by Tick Protein Salp20

Autor: Stefan P Berger, Jacob van den Born, Wendy Dam, Mohamed R. Daha, Ditmer T. Talsma, Marc A. Seelen, Rosa G.M. Lammerts

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 11:1643. Frontiers Media SA
Frontiers in Immunology, Vol 11 (2020)

Introduction: Proteinuria contributes to progression of renal damage, partly by complement activation on proximal tubular epithelial cells. By pattern recognition, properdin has shown to bind to heparan sulfate proteoglycans on tubular epithelium and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d37dc01c09273bb7a7038997cbdbb76
http://europepmc.org/articles/PMC7426487