Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Wendy Choy"'
Autor:
Karl D. Normington, Chi B. Vu, Jill C. Milne, Jeffrey Song, Angela Cote, Michael Hirsch, Nekeya Meade, Meghan Davis, David P. Carney, Michael R. Jirousek, Wendy Choy, Philip D. Lambert, David J. Gagne, Elden Lainez, Robert B. Perni
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1416-1420
A series of triamide derivatives bearing a benzothiazole core is shown to be potent microsomal triglyceride transfer protein (MTP) inhibitors. In order to minimize liver toxicity, these compounds have been optimized to have activity only in the enter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6812b78c06459cd6bf93d39fa80bf37f
https://doi.org/10.1016/j.bmcl.2009.01.044
https://doi.org/10.1016/j.bmcl.2009.01.044
Autor:
Heidi Galonek, J. Joshua Smith, Kristine Israelian, Yihua Xu, Wendy Choy, Jean Bemis, Christoph H. Westphal, Michael R. Jirousek, Jill C. Milne, Ethan Hoffmann, David A. Sinclair, Xiaohong Wang, Robert B. Perni, Yuecheng Yang, Michael Morrison, Lei Jin, Yu Xia, David P. Carney
Publikováno v:
Protein Science. 18:514-525
SIRT3 is a key mitochondrial protein deacetylase proposed to play key roles in regulating mitochondrial metabolism but there has been considerable debate about its actual size, the sequences required for activity, and its subcellular localization. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fa222d586b80340a8571dfb88bbf694
https://doi.org/10.1002/pro.50
https://doi.org/10.1002/pro.50
Autor:
Wendy Choy, Kristine Israelian, J. Joshua Smith, Simon Schenk, Siva Lavu, David P. Carney, Olivier Boss, Philip D. Lambert, Lei Jin, David J. Gagne, David A. Sinclair, Michael R. Jirousek, Andre Iffland, Amy V. Lynch, Jean Bemis, Roger Xie, Robert B. Perni, Pui Yee Ng, Hongying Yang, Jill C. Milne, Jeremy S. Disch, Chi B. Vu, Peter J. Elliott, Jerrold M. Olefsky, Christoph H. Westphal, Heidi Galonek, Oliver Medvedik, Joseph J. Nunes
Publikováno v:
Nature. 450:712-716
Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes1,2. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09038e77c147549472bcdfb983cab962
https://doi.org/10.1038/nature06261
https://doi.org/10.1038/nature06261
Publikováno v:
The Journal of Infectious Diseases. 194:1135-1140
Fabry disease is an X-linked recessive disorder in which affected persons lack alpha-galactosidase A (alpha -GalA), which leads to excess glycosphingolipids in tissues, mainly globotriaosylceramide (Gb3). Gb3 is the cellular receptor for Shiga toxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1531698780f6ecd07d8cdd50287f88d9
https://doi.org/10.1086/507705
https://doi.org/10.1086/507705
Autor:
Michael R. Jirousek, Robert B. Perni, Christoph H. Westphal, Hao Peng, Wei Wentao, Wendy Choy, Han Dai, Jill C. Milne, Jean Bemis, Chen Mao, Jianhua Cai, Yaobin Jiang, Lei Jin
Publikováno v:
The Journal of biological chemistry. 284(36)
SIRT3 is a major mitochondrial NAD(+)-dependent protein deacetylase playing important roles in regulating mitochondrial metabolism and energy production and has been linked to the beneficial effects of exercise and caloric restriction. SIRT3 is emerg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7546fd9a80c6df2e4c2a9c7a5a1c1bc
https://pubmed.ncbi.nlm.nih.gov/19535340
https://pubmed.ncbi.nlm.nih.gov/19535340
Autor:
Zhuolu Yang, Joan R. Butterton, Chengru Zhu, Fernando Ruiz-Perez, Wendy Choy, Edgar C. Boedeker, Katherine Davis, Ying Mao, Karla M. Greco, Veronica L. Hackethal
Publikováno v:
Vaccine. 24(18)
In this report, we describe the use of an attenuated regulatory mutant of a rabbit enteropathogenic Escherichia coli (rEPEC) as a live vaccine vector to deliver heterologous protein antigens using two dedicated transport systems, a Salmonella autotra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8dc9038bcdd56efb00985f33692a3f7
https://pubmed.ncbi.nlm.nih.gov/16098637
https://pubmed.ncbi.nlm.nih.gov/16098637