PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling

Autor: Adnan Shami Shah, Alex G. Batrouni, Dongsung Kim, Amith Punyala, Wendy Cao, Chun Han, Michael L. Goldberg, Marcus B. Smolka, Jeremy M. Baskin

Publikováno v: Cell Reports, Vol 27, Iss 7, Pp 2157-2170.e8 (2019)

Summary: Wnt signaling pathways direct key physiological decisions in development. Here, we establish a role for a pleckstrin homology domain-containing protein, PLEKHA4, as a modulator of signaling strength in Wnt-receiving cells. PLEKHA4 oligomeriz

Externí odkaz: https://doaj.org/article/11bfc18ee02d480fb644965b5c242324

Chemoselective and Site-Selective Reductions Catalyzed by a Supramolecular Host and a Pyridine–Borane Cofactor

Autor: Wendy Cao, F. Dean Toste, Kenneth N. Raymond, Mariko Morimoto, Robert G. Bergman

Publikováno v: Journal of the American Chemical Society, vol 143, iss 4

Supramolecular catalysts emulate the mechanism of enzymes to achieve large rate accelerations and precise selectivity under mild and aqueous conditions. While significant strides have been made in the supramolecular host-promoted synthesis of small m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7c697d43b286aba76c0f833cfa5038
https://doi.org/10.1021/jacs.0c12479

Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish

Autor: Jeremy M. Baskin, Wendy Cao, Johnny Ye, Jessica L. Daughtry

Publikováno v: ACS chemical biology. 15(2)

Galactose is one of only nine monosaccharide precursors used to build complex glycans in vertebrates. Defects in galactose metabolism cause galactosemia and lysosomal storage diseases, and the ability to visualize metabolic flux through these pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2125ede2504b25b367b5e663f86956d8
https://pubmed.ncbi.nlm.nih.gov/31976645

Clickable Galactose Analogs for Imaging Glycans in Developing Zebrafish

Autor: Jeremy Baskin, Johnny Ye, Wendy Cao, Jessica Daughtry

Galactose is one of only nine monosaccharide precursors used to build complex glycans in vertebrates. Defects in galactose metabolism cause galactosemia and lysosomal storage diseases, and the ability to visualize metabolic flux through these pathway

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b80d7efafce6e86dc9acae8e218b9fa
https://doi.org/10.26434/chemrxiv.10083383.v1

A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals

Autor: Tyler C. Detomasi, Timothy A. Su, Christopher J. Chang, Wendy Cao, Shang Jia, Marie C. Heffern, Diyala S. Shihadih, Andreas Stahl

Publikováno v: Su, TA; Shihadih, DS; Cao, W; Detomasi, TC; Heffern, MC; Jia, S; et al.(2018). A Modular Ionophore Platform for Liver-Directed Copper Supplementation in Cells and Animals. Journal of the American Chemical Society, 140(42), 13764-13774. doi: 10.1021/jacs.8b08014. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/2bp8762d
Journal of the American Chemical Society, vol 140, iss 42

© 2018 American Chemical Society. Copper deficiency is implicated in a variety of genetic, neurological, cardiovascular, and metabolic diseases. Current approaches for addressing copper deficiency rely on generic copper supplementation, which can po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e462c6402b4f7e6bb2a478c587f758ad
http://www.escholarship.org/uc/item/2bp8762d