Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Wendy C. Magee"'
Publikováno v:
Emerging Microbes & Infections
New drugs to treat hepatitis C are expected to be approved over the next few years which promise to cure nearly all patients. However, due to issues of expected drug resistance, suboptimal activity against diverse hepatitis C virus (HCV) genotypes an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41af99d7dedec71f0102179d6fa68fe6
https://doi.org/10.1038/emi.2013.79
https://doi.org/10.1038/emi.2013.79
Autor:
David H. Evans, Douglas D. Richman, Nadejda Valiaeva, Karl Y. Hostetler, James R. Beadle, Wendy C. Magee
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:5063-5072
( S )-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC [cidofovir]) and ( S )-9-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine (HPMPA) are potent inhibitors of a variety of DNA viruses. These drugs possess a 3′-hydroxyl equivalent which could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be782402078cdac35b9a0541a5da7327
https://doi.org/10.1128/aac.05161-11
https://doi.org/10.1128/aac.05161-11
Publikováno v:
Antimicrobial Agents and Chemotherapy. 52:586-597
The acyclic nucleoside phosphonate drug ( S )-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine [( S )-HPMPA], is a broad-spectrum antiviral and antiparasitic agent. Previous work has shown that the active intracellular metabolite of this compound, ( S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2c24e64e460cbef1b7e24e5964f644
https://doi.org/10.1128/aac.01172-07
https://doi.org/10.1128/aac.01172-07
Publikováno v:
Journal of Bacteriology. 181:1728-1732
The ability to modify RNA secondary structure is crucial for numerous cellular processes. We have characterized two RNA helicase genes, crhB and crhC , which are differentially expressed in the cyanobacterium Anabaena sp. strain PCC 7120. crhC transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b42d7cc866f03bad2969250d5e6e49d
https://doi.org/10.1128/jb.181.6.1728-1732.1999
https://doi.org/10.1128/jb.181.6.1728-1732.1999
Autor:
John Lok Man Law, Khaled Barakat, David H. Evans, Jack A. Tuszynski, D. Lorne Tyrrell, Alessio Prunotto, Wendy C. Magee, Michael Houghton
Publikováno v:
Journal of chemical information and modeling. 53(11)
The hepatitis C virus (HCV) RNA polymerase, NS5B, is a leading target for novel and selective HCV drug design. The enzyme has been the subject of intensive drug discovery aimed at developing direct acting antiviral (DAA) agents that inhibit its activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cfa878924e8e44f2baeecb48b40ac11
https://pubmed.ncbi.nlm.nih.gov/24116674
https://pubmed.ncbi.nlm.nih.gov/24116674
Autor:
David H. Evans, Wendy C. Magee
Publikováno v:
Antiviral research. 96(2)
One class of compounds that has shown promise as antiviral agents are the (S)-[3-hydroxy-2-(phosphonomethoxy)propyl] (HPMP) nucleosides, members of the broader class of acyclic nucleoside phosphonates. These HPMP nucleosides are nucleotide analogs an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499c8973c8d07fecb0ddbb223adbd339
https://pubmed.ncbi.nlm.nih.gov/22960154
https://pubmed.ncbi.nlm.nih.gov/22960154
Autor:
Olivier Julien, Wendy C. Magee, James R. Beadle, David H. Evans, Karl Y. Hostetler, Subhrangsu Chatterjee, Brian D. Sykes
Publikováno v:
Journal of the American Chemical Society. 133(7)
Cidofovir (1(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine, CDV) is a potent inhibitor of orthopoxvirus DNA replication. Prior studies have shown that, when CDV is incorporated into a growing primer strand, it can inhibit both the 3'-to-5' exonuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a040da1fd61c0914a8f0019326849f9
https://pubmed.ncbi.nlm.nih.gov/21280608
https://pubmed.ncbi.nlm.nih.gov/21280608
Publikováno v:
Journal of virological methods. 161(1)
Poxviruses are large DNA viruses that replicate in discrete locations in the cytoplasm of infected cells called viral factories. Because the host cell DNA replication machinery is located in the nucleus, poxviruses encode many of the proteins require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd131d6dffd388b8acf164bdbfa2387e
https://pubmed.ncbi.nlm.nih.gov/19477201
https://pubmed.ncbi.nlm.nih.gov/19477201
Autor:
Nicholas van Buuren, Brianne Couturier, Robyn Shipclark, Wendy C. Magee, Kelly Watmough, Stephanie Campbell, Michele Barry, Alastair Teale
Cellular homeostasis depends on an intricate balance of protein expression and degradation. The ubiquitinproteasome pathway plays a crucial role in specifically targeting proteins tagged with ubiquitin for destruction. This degradation can be effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c53696505eb86088e6d26b2c8cce9e3
https://europepmc.org/articles/PMC2643736/
https://europepmc.org/articles/PMC2643736/
Publikováno v:
Antimicrobial agents and chemotherapy. 49(8)
Cidofovir (CDV) is a broad-spectrum antiviral agent that has been approved for clinical use in the treatment of cytomegalovirus retinitis. It has also been used off label to treat a variety of other viral infections, including those caused by orf and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaba2ba05ce3ce0a843108da4690474
https://pubmed.ncbi.nlm.nih.gov/16048917
https://pubmed.ncbi.nlm.nih.gov/16048917