Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Wendy Blakemore"'
Foot-and-mouth disease virus (FMDV) capsids are inherently labile under mildly acidic conditions, dissociating to pentamers at pH values in the region of 6·5, with the release of protein 1A and the viral RNA. This acid-induced disassembly is thought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3d59767b5ec143d51541cd5b82bc36
https://ora.ox.ac.uk/objects/uuid:852fbf47-cb27-4c76-8adf-0683d1fdd861
https://ora.ox.ac.uk/objects/uuid:852fbf47-cb27-4c76-8adf-0683d1fdd861
Publikováno v:
Journal of Virology. 74:4949-4956
Field isolates of foot-and-mouth disease virus (FMDV) have been shown to use the RGD-dependent integrin alphavbeta3 as a cellular receptor on cultured cells. However, several other RGD-dependent integrins may have the potential to act as receptors fo
Autor:
Elizabeth E. Fry, Wendy Blakemore, David I. Stuart, John Newman, Susan M. Lea, Robin Abu-Ghazaleh, Terry Jackson, Stephen Curry, Andrew M. Q. King
Publikováno v:
Scopus-Elsevier
Empty capsids of foot-and-mouth disease virus (FMDV) type A22 Iraq 24/64, whose structure has been solved by X-ray crystallography, are unusual for picornaviruses since they contain VP2 and VP4, the cleavage products of the protein precursor VP0. Bot
Autor:
Elizabeth E. Fry, Derek T. Logan, David I. Stuart, Stephen Curry, Terry Jackson, Wendy Blakemore, John Newman, Andrew M. Q. King, Robin Abu-Ghazaleh, Susan M. Lea
Publikováno v:
Structure. 3(6):571-580
Background: Foot-and-mouth disease viruses (FMDVs) are members of the picornavirus family and cause an economically important disease of cloven-hoofed animals. To understand the structural basis of antigenic variation in FMDV, we have determined the
Autor:
John Newman, R.Abu Ghazaleh, David I. Stuart, Andrew M. Q. King, Susan M. Lea, Emiliana Brocchi, Stephen Curry, Elizabeth E. Fry, J Hernéndez, Esteban Domingo, Wendy Blakemore, Mauricio G. Mateu
Publikováno v:
Structure. 2:123-139
Background Picornaviruses are responsible for a wide range of mammalian diseases and, in common with other RNA viruses, show considerable antigenic variation. Foot-and-mouth disease viruses (FMDVs) constitute one genus of the picornavirus family and
Autor:
Elizabeth E. Fry, Derek T. Logan, Terry Jackson, Susan M. Lea, Stephen Curry, Robin Abu-Ghazaleh, David I. Stuart, John Newman, Andrew M. Q. King, Wendy Blakemore
Publikováno v:
Journal of Molecular Biology. 228:1263-1268
Foot-and-mouth disease viruses from serotypes O, A and C have been crystallized. The particular strains studied include O1K, A10(61), A22 Iraq 24/64, A24 Cruzeiro and C-S8c1. In addition, crystals have been grown of G67, a monoclonal antibody neutral
Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors
Autor:
Christopher William Murray, Steven Howard, Gianni Chessari, Nigel I. Howard, Wendy Blakemore, Rob L. M. van Montfort, Miles Congreve, Harren Jhoti, Chris Abell, Lisa C A Seavers
Publikováno v:
Journal of medicinal chemistry. 49(4)
The screening of fragments is an alternative approach to high-throughput screening for the identification of leads for therapeutic targets. Fragment hits have been discovered using X-ray crystallographic screening of protein crystals of the serine pr
Autor:
David I. Stuart, Susan M. Lea, Saloua Najjam, Stephen Curry, Elizabeth E. Fry, Alison Burman, Laura C. Miller, Wendy Blakemore, Terry Jackson, Andrew M. Q. King, John Newman
Publikováno v:
The Journal of general virology. 86(Pt 7)
Foot-and-mouth disease viruses (FMDVs) target epithelial cells via integrin receptors, but can acquire the capacity to bind cell-surface heparan sulphate (or alternative receptors) on passage in cell culture. Vaccine viruses must be propagated in cel
Autor:
Laura C. Miller, Amha Atakilit, Dean Sheppard, Wendy Blakemore, Terry Jackson, Andrew M. Q. King
Field isolates of foot-and-mouth disease virus (FMDV) are believed to use RGD-dependent integrins as cellular receptors in vivo. Using SW480 cell transfectants, we have recently established that one such integrin, αvβ6, functions as a receptor for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd5303424aa7eb4b9af6692db2085d8
https://europepmc.org/articles/PMC114161/
https://europepmc.org/articles/PMC114161/
Autor:
Wendy Blakemore, Elizabeth E. Fry, Fiona M. Ellard, A. R. Samuel, John Newman, Susan M. Lea, David I. Stuart, Andrew M. Q. King, Terry Jackson, Robin Abu-Ghazaleh
Publikováno v:
The EMBO journal. 18(3)
Heparan sulfate has an important role in cell entry by foot-and-mouth disease virus (FMDV). We find that subtype O1 FMDV binds this glycosaminoglycan with a high affinity by immobilizing a specific highly abundant motif of sulfated sugars. The bindin