Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Wendy Bernhard"'
Autor:
Ashley R. Sutherland, Brijesh Parlekar, David W. Livingstone, Andrés X. Medina, Wendy Bernhard, Tays Hernández García, John DeCoteau, C. Ronald Geyer
Publikováno v:
Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Adoptive cell cancer therapies aim to re-engineer a patient’s immune cells to mount an anti-cancer response. Chimeric antigen receptor T and natural killer cells have been engineered and proved successful in treating some cancer
Externí odkaz:
https://doaj.org/article/cb8f4f0df89549488e5fbe56f8fd5d8c
Autor:
Wendy Bernhard, Kris Barreto, Darien Toledo, Ayman El-Sayed, Kimberly A. Jett, Angel Casaco, Humphrey Fonge, C. Ronald Geyer
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Molecular-targeted imaging probes can be used with a variety of imaging modalities to detect diseased tissues and guide their removal. EGFR is a useful biomarker for a variety of cancers, because it is expressed at high levels relative to no
Externí odkaz:
https://doaj.org/article/bed93400588348b38db2a18420019388
Autor:
Wendy Bernhard, Kris Barreto, Ayman El-Sayed, Carolina Gonzalez, Raja Solomon Viswas, Darien Toledo, Angel Casaco, John DeCoteau, Humphrey Fonge, Clarence Ronald Geyer
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Background Epidermal growth factor receptor (EGFR) is a target for cancer therapy as it is overexpressed in a wide variety of cancers. Therapeutic antibodies that bind EGFR are being evaluated in clinical trials as imaging agents for positro
Externí odkaz:
https://doaj.org/article/9a3e8851466844399ff266a99175fcea
Autor:
Pargol Hashemi, Kris Barreto, Wendy Bernhard, Adam Lomness, Nicolette Honson, Tom A Pfeifer, P Richard Harrigan, Ivan Sadowski
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 2, Pp 160-174 (2017)
Abstract Highly active antiretroviral therapy (HAART) has improved the outlook for the HIV epidemic, but does not provide a cure. The proposed “shock‐and‐kill” strategy is directed at inducing latent HIV reservoirs, which may then be purged v
Externí odkaz:
https://doaj.org/article/01a3cd56f2dc4223af7260be31d0a938
Autor:
Mohammad Wajih Alam, Khan A. Wahid, Md. Fahmid Islam, Wendy Bernhard, Clarence R. Geyer, Franco J. Vizeacoumar
Publikováno v:
Applied Sciences, Vol 9, Iss 17, p 3510 (2019)
Fluorescence imaging is a well-known method for monitoring fluorescence emitted from the subject of interest and provides important insights about cell dynamics and molecules in mammalian cells. Currently, many solutions exist for measuring fluoresce
Externí odkaz:
https://doaj.org/article/35599594965643b0a68ec6ffc268cc43
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77052 (2013)
During HIV-1 infection a population of latently infected cells is established. This population is the major obstacle preventing total eradication of the virus from AIDS patients. HIV-1 latency is thought to arise by various mechanisms including repre
Externí odkaz:
https://doaj.org/article/259f3517c3c34088a9ec67bf6858014c
Publikováno v:
Bioconjugate chemistry. 33(5)
Microbubbles are ultrasound contrast agents that can adhere to disease-related vascular biomarkers when functionalized with binding ligands such as antibodies or peptides. The biotin-streptavidin approach has predominantly been used as the microbubbl
Publikováno v:
Cancers
Cancers, Vol 14, Iss 300, p 300 (2022)
Cancers; Volume 14; Issue 2; Pages: 300
Cancers, Vol 14, Iss 300, p 300 (2022)
Cancers; Volume 14; Issue 2; Pages: 300
Simple Summary The immune system responds to abnormal cell growth by sending immune cells to kill them. The immune cell response is very important since it can usually stop abnormal cells from growing and spreading. Immuno-therapeutics used to treat
Autor:
Clarence Ronald Geyer, Viswas Raja Solomon, Kris Barreto, Humphrey Fonge, Rufael Chekol, Wayne Hill, Wendy Bernhard, Siddesh V. Hartimath, Elahe Alizadeh
Publikováno v:
Molecular Pharmaceutics. 16:4807-4816
Insulin growth factor receptor (IGF-1R) is overexpressed in many cancers of epithelial origin, where it confers enhanced proliferation and resistance to therapies targeted at other receptors. Anti-IGF-1R monoclonal antibodies have not demonstrated si
Autor:
Siddesh V. Hartimath, Humphrey Fonge, Angel Casaco Parada, Elahe Alizadeh, Wayne Hill, Wendy Bernhard, Rufael Chekol, Kris Barreto, Clarence Ronald Geyer, Viswas Raja Solomon
Publikováno v:
Journal of Nuclear Medicine. 60:1103-1110
Epidermal growth factor receptor I (EGFR) is overexpressed in most cancers of epithelial origin. Antibody drug conjugates (ADCs) with PEGylated-maytansine (PEG-DM1) show promise in vitro and in vivo. However, in vivo biodistribution data for ADCs wit