Výsledky vyhledávání - "Wendy Anemaet"

Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models

Autor: Anna Plaas, Michael A. Diaz, John D. Sandy, Jun Li, Wendy Anemaet, Samuel Buchanan, Katalin Mikecz, Anne-Marie Malfait, Micky D. Tortorella

Publikováno v: Journal of Orthopaedic Research. 29:516-522

To investigate the role of ADAMTS5 in murine osteoarthritis (OA), resulting from destabilization of the medial meniscus (DMM model) or from TGFb1 injection and enforced uphill treadmill running (TTR model). Wild-type (WT) and ADAMTS5-/- mice were sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::392daffe1f79e3ebacff9c20d53a1d90
https://doi.org/10.1002/jor.21215

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Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

Autor: Wendy Anemaet, Jennifer Velasco, Anna Plaas, Jun Li, Daniel J. Gorski, Jun Takeuchi, John D. Sandy

Publikováno v: Arthritis Research & Therapy

Introduction The mechanism by which intra-articular injection of hyaluronan (HA) ameliorates joint pathology is unknown. Animal studies have shown that HA can reduce synovial activation, periarticular fibrosis and cartilage erosion; however, its spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66dc61f8ae065f522164286d4e52e38a

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