Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Wendy Sharp"'
Publikováno v:
EClinicalMedicine, Vol 60, Iss , Pp 102021- (2023)
Summary: Background: Attention deficit/hyperactivity disorder (ADHD) is usually conceptualized as a childhood-onset neurodevelopmental disorder, in which symptoms either decrease steadily into adulthood or remain stable. A recent study challenged thi
Externí odkaz:
https://doaj.org/article/d2949fc80a124cec847f4cb21ba457af
Autor:
Gustavo Sudre, Derek E. Gildea, Gauri G. Shastri, Wendy Sharp, Benjamin Jung, Qing Xu, Pavan K. Auluck, Laura Elnitski, Andreas D. Baxevanis, Stefano Marenco, Philip Shaw
Publikováno v:
Molecular Psychiatry. 28:792-800
Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic understanding of this disorder. To address t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0852fecfbe663edc06a8f7ff8afeb9
https://doi.org/10.1038/s41380-022-01844-9
https://doi.org/10.1038/s41380-022-01844-9
Publikováno v:
Biol Psychiatry
Background Twin studies show that age-related change in symptoms of attention-deficit/hyperactivity disorder (ADHD) is heritable. However, we do not know the heritability of the development of the neural substrates underlying the disorder. Here, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26226f698432002aa10cf7cc25c2c3f1
https://doi.org/10.1016/j.biopsych.2020.06.007
https://doi.org/10.1016/j.biopsych.2020.06.007
A Longitudinal Study of Resting-State Connectivity and Response to Psychostimulant Treatment in ADHD
Publikováno v:
Am J Psychiatry
Psychostimulants are first-line pharmacological treatments for attention deficit hyperactivity disorder (ADHD), although symptom reduction varies widely between patients and these individual differences in treatment response are poorly understood. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823a36d0d329501e978972a8e5d83a5a
https://pubmed.ncbi.nlm.nih.gov/34383563
https://pubmed.ncbi.nlm.nih.gov/34383563
Autor:
Wendy Sharp, Jennifer Frederick, Ayaka Ishii-Takahashi, Philip Shaw, Aman Mangalmurti, Saadia Choudhury, Gustavo Sudre
Publikováno v:
Molecular psychiatry
There are now large-scale data on which common genetic variants confer risk for attention deficit hyperactivity disorder (ADHD). Here, we use mediation analyses to explore how cognitive and neural features might explain the association between common
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ade474174f84e6ffc63f06a42aae5f2d
https://doi.org/10.1038/s41380-019-0350-3
https://doi.org/10.1038/s41380-019-0350-3
Publikováno v:
Neuropsychopharmacology
Previous cross-sectional work has demonstrated resting-state connectivity abnormalities in children and adolescents with attention/deficit hyperactivity disorder (ADHD) relative to typically developing controls. However, it is unclear to what extent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620a49fdfaf6eb7547053e13e3f126f4
https://pubmed.ncbi.nlm.nih.gov/33558680
https://pubmed.ncbi.nlm.nih.gov/33558680
Autor:
Gustavo Sudre, Paul Kundzicz, Marine Bouyssi-Kobar, Philip Shaw, Luke Norman, Wendy Sharp, Saadia Choudhury
Publikováno v:
Mol Psychiatry
Childhood attention deficit hyperactivity disorder (ADHD) shows a highly variable course with age: some individuals show improving, others stable or worsening symptoms. The ability to predict symptom course could help individualize treatment and guid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcf6b22565ceb3d38a9f628e04e23b0
https://pubmed.ncbi.nlm.nih.gov/33173195
https://pubmed.ncbi.nlm.nih.gov/33173195
Publikováno v:
Proceedings of the National Academy of Sciences. 114:11787-11792
We have a limited understanding of why many children with attention deficit hyperactivity disorder do not outgrow the disorder by adulthood. Around 20-30% retain the full syndrome as young adults, and about 50% show partial, rather than complete, rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31750aaeff6bf9e309fcef23ed1a33b
https://doi.org/10.1073/pnas.1705229114
https://doi.org/10.1073/pnas.1705229114
Publikováno v:
American Journal of Psychiatry. 174:867-876
Understanding the neural processes tied to the adult outcome of childhood attention deficit hyperactivity disorder (ADHD) could guide novel interventions to improve its clinical course. It has been argued that normalization of prefrontal cortical act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f128747707060b5b2a176ec688353e78
https://doi.org/10.1176/appi.ajp.2017.16111313
https://doi.org/10.1176/appi.ajp.2017.16111313
Autor:
Frank X. Donovan, Settara C. Chandrasekharappa, Laura Elnitski, Chen Yc, Wendy Sharp, Philip Shaw, Nancy F. Hansen, Gustavo Sudre
Publikováno v:
Molecular psychiatry
The study of monozygotic twins discordant for attention deficit hyperactivity disorder can elucidate mechanisms that contribute to the disorder, which affects ~7% of children. First, using in vivo neuroanatomic imaging on 14 pairs of monozygotic twin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95c255b00f152f34ecd393bf9b50248
https://doi.org/10.1038/mp.2017.45
https://doi.org/10.1038/mp.2017.45