Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Wendy, Tran"'
Autor:
Bill W. G. L. Chan, Nicholas B. Lynch, Wendy Tran, Jack M. Joyce, G. Paul Savage, Wim Meutermans, Andrew P. Montgomery, Michael Kassiou
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Fragment-based drug discovery (FBDD) has emerged as a powerful strategy to confront the challenges faced by conventional drug development approaches, particularly in the context of central nervous system (CNS) disorders. FBDD involves the screening o
Externí odkaz:
https://doaj.org/article/fa640cc91f804f6ab374989d624f7f85
Autor:
Lisa Ta, Brandon L. Tsai, Weixian Deng, Jihui Sha, Grigor Varuzhanyan, Wendy Tran, James A. Wohlschlegel, Janai R. Carr-Ascher, Owen N. Witte
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108480- (2023)
Summary: Mutated Ras and Raf kinases are well-known to promote cancer metastasis via flux through the Ras/Raf/MEK/ERK (mitogen-activated protein kinase [MAPK]) pathway. A role for non-mutated Raf in metastasis is also emerging, but the key mechanisms
Externí odkaz:
https://doaj.org/article/50c08eec40e64d8eaf3c2bad01473b66
Autor:
Patricia Soegiantho, Patricia Gillian Suryawinata, Wendy Tran, Omar Kujan, Bryar Koyi, Nabil Khzam, Leticia Algarves Miranda
Publikováno v:
Prosthesis, Vol 5, Iss 2, Pp 378-424 (2023)
Background: Immediate implant placement (IIP) or Type I implants have become more attractive than conventional implant placements as it reduces the number of surgical procedures and allows faster delivery of the final restoration compared to conventi
Externí odkaz:
https://doaj.org/article/d608b148f7d6429a93b1ce0323bf36e3
Autor:
Yang Pan, John W. Phillips, Beatrice D. Zhang, Miyako Noguchi, Eric Kutschera, Jami McLaughlin, Pavlo A. Nesterenko, Zhiyuan Mao, Nathanael J. Bangayan, Robert Wang, Wendy Tran, Harry T. Yang, Yuanyuan Wang, Yang Xu, Matthew B. Obusan, Donghui Cheng, Alex H. Lee, Kathryn E. Kadash-Edmondson, Ameya Champhekar, Cristina Puig-Saus, Antoni Ribas, Robert M. Prins, Christopher S. Seet, Gay M. Crooks, Owen N. Witte, Yi Xing
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 21
Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe I soform peptides from R NA splicing for I mmunotherapy target S creening (IRIS), a computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93609197fd5c544787a244456cbfc71
https://doi.org/10.1073/pnas.2221116120
https://doi.org/10.1073/pnas.2221116120
Autor:
Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Natalie Tsubamoto, Miyako Noguchi, Jami McLaughlin, Wendy Tran, Sohyung Lee, Donghui Cheng, Joseph de Rutte, Giselle Burton Sojo, Owen N. Witte, Dino Di Carlo
The ability to selectively bind to antigenic peptides and secrete cytokines can define populations of cells with therapeutic potential in emerging T cell receptor (TCR) immunotherapies. We leverage cavity-containing hydrogel microparticles, called na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::852e915933758f2cc987fb1530810116
https://doi.org/10.1101/2023.01.17.524440
https://doi.org/10.1101/2023.01.17.524440
Autor:
Elinor Hortle, David I. Roper, Warwick J. Britton, Richard J. Payne, Gregory M. Cook, Wendy Tran, Paige M. E. Hawkins, Alexander Stoye, Christopher G. Dowson, Rebecca E Audette, Thomas Balle, Jessica L. Ochoa, Gayathri Nagalingam, Daniel J Ford, Ali Saad Kusay, Venugopal Pujari, Roger G. Linington, Chen-Yi Cheung, Dean C. Crick, Eric J. Rubin, Stefan H. Oehlers, Susan A. Charman
Publikováno v:
Journal of Medicinal Chemistry. 64:17326-17345
Herein, we report the design and synthesis of inhibitors of Mycobacterium tuberculosis (Mtb) phospho-MurNAc-pentapeptide translocase I (MurX), the first membrane-associated step of peptidoglycan synthesis, leveraging the privileged structure of the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e08cda86f6791396aa219a030366f02
https://doi.org/10.1021/acs.jmedchem.1c01407
https://doi.org/10.1021/acs.jmedchem.1c01407
Autor:
Zhiyuan Mao, Pavlo A. Nesterenko, Jami McLaughlin, Weixian Deng, Giselle Burton Sojo, Donghui Cheng, Miyako Noguchi, William Chour, Diana C. DeLucia, Kathryn A. Finton, Yu Qin, Matthew B. Obusan, Wendy Tran, Liang Wang, Nathanael J. Bangayan, Lisa Ta, Chia-Chun Chen, Christopher S. Seet, Gay M. Crooks, John W. Phillips, James R. Heath, Roland K. Strong, John K. Lee, James A. Wohlschlegel, Owen N. Witte
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 31
Tissue-specific antigens can serve as targets for adoptive T cell transfer-based cancer immunotherapy. Recognition of tumor by T cells is mediated by interaction between peptide–major histocompatibility complexes (pMHCs) and T cell receptors (TCRs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39afba213dbd49e1152b82e74057d229
https://escholarship.org/uc/item/7k4312v2
https://escholarship.org/uc/item/7k4312v2
Autor:
Wendy, Tran, Ali S, Kusay, Paige M E, Hawkins, Chen-Yi, Cheung, Gayathri, Nagalingam, Venugopal, Pujari, Daniel J, Ford, Alexander, Stoye, Jessica L, Ochoa, Rebecca E, Audette, Elinor, Hortle, Stefan H, Oehlers, Susan A, Charman, Roger G, Linington, Eric J, Rubin, Christopher G, Dowson, David I, Roper, Dean C, Crick, Thomas, Balle, Gregory M, Cook, Warwick J, Britton, Richard J, Payne
Publikováno v:
Journal of medicinal chemistry. 64(23)
Herein, we report the design and synthesis of inhibitors of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::00df1b626c713af803b1ee55c15e4b74
https://pubmed.ncbi.nlm.nih.gov/34845906
https://pubmed.ncbi.nlm.nih.gov/34845906
Autor:
Chia-Chun Chen, Kai Song, Wendy Tran, Matthew Obusan, Tyler Sugimoto, Katherine Sheu, Donghui Cheng, Grigor Varuzhanyan, Liang Wang, Lisa Ta, Zhiyuan Mao, Nathanael Bangayan, Jung-Wook Park, Thomas Graerber, Owen Witte
Publikováno v:
Cancer Research. 82:789-789
Small cell carcinomas of the lung, bladder, and prostate share similar transcription patterns and drug sensitivities. Due to their high cellular plasticity, these cancers often escape treatment through a trans-differentiation from adenocarcinoma to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::763566e81c00303aff7d17104c59a1fd
https://doi.org/10.1158/1538-7445.am2022-789
https://doi.org/10.1158/1538-7445.am2022-789
Autor:
Lisa H. Ta, Janai R. Carr-Ascher, Weixian Deng, Brandon L. Tsai, Wendy Tran, Donny Gun, Donghui Cheng, Jihui Sha, Yeonjoo Hwang, John W. Phillips, Matthew B. Obusan, Nathanael J. Bangayan, Miyako Noguchi, Zhiyuan Mao, Chia-Chun Chen, Liang Wang, Grigor Varuzhanyan, John D. Gordon, James W. Wohlschlegel, Owen N. Witte
Publikováno v:
Cancer Research. 82:2438-2438
Many aggressive epithelial cancers do not carry targetable driver mutations (Mendiratta et al. 2021, NCI-MATCH Clinical trial NCT02465060). Commonly altered signaling pathways highlight the propensity for tumors to depend on such pathways for growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae1feb97a6c921245ae15af6d1a39698
https://doi.org/10.1158/1538-7445.am2022-2438
https://doi.org/10.1158/1538-7445.am2022-2438